COMSAE Mid-Study Progress Exam Questions
With Correct Answers (Verified Answers) Plus
Rationales 2026 Q&A | Instant Download Pdf
1. A 23-year-old woman presents with fatigue, weight gain, and cold
intolerance. Labs show elevated TSH and low free T4. Which is the
most likely diagnosis?
A. Graves disease
B. Hashimoto thyroiditis
C. Subacute thyroiditis
D. Thyroid cancer
Answer: B
The findings of elevated TSH with low free T4 indicate primary
hypothyroidism. Hashimoto thyroiditis is the most common
cause in iodine-sufficient regions and is autoimmune-mediated
destruction of thyroid tissue.
2. A 65-year-old man with long-standing COPD develops increased
PaCO2 with renal compensation. What acid-base disorder is
, present?
A. Metabolic acidosis
B. Respiratory acidosis
C. Metabolic alkalosis
D. Respiratory alkalosis
Answer: B
COPD leads to hypoventilation and CO2 retention, causing
respiratory acidosis. Renal compensation increases bicarbonate
over time.
3. Which vitamin deficiency is associated with peripheral neuropathy
and Wernicke encephalopathy?
A. Vitamin B1
B. Vitamin B6
C. Vitamin B12
D. Vitamin C
Answer: A
Thiamine (B1) deficiency leads to Wernicke-Korsakoff syndrome
and peripheral neuropathy due to impaired glucose metabolism
in neurons.
,4. A patient has a mutation in dystrophin. What condition is most
likely?
A. Myasthenia gravis
B. Duchenne muscular dystrophy
C. Multiple sclerosis
D. Lambert-Eaton syndrome
Answer: B
Dystrophin gene mutations cause Duchenne muscular dystrophy,
characterized by progressive proximal muscle weakness in
childhood.
5. A 30-year-old man has painless hematuria and a renal mass.
Which gene is most commonly mutated?
A. APC
B. VHL
C. RB1
D. BRCA1
Answer: B
Von Hippel-Lindau gene mutation is associated with clear cell
renal cell carcinoma presenting with hematuria and a renal
mass.
, 6. What is the primary site of iron absorption?
A. Stomach
B. Duodenum
C. Jejunum
D. Ileum
Answer: B
Iron is primarily absorbed in the duodenum via DMT1
transporters.
7. Which organism is classically associated with rheumatic fever?
A. Staphylococcus aureus
B. Streptococcus pyogenes
C. Streptococcus pneumoniae
D. Enterococcus faecalis
Answer: B
Group A Streptococcus infection can lead to rheumatic fever due
to molecular mimicry.
8. A child presents with slapped cheek rash. What is the causative
agent?
With Correct Answers (Verified Answers) Plus
Rationales 2026 Q&A | Instant Download Pdf
1. A 23-year-old woman presents with fatigue, weight gain, and cold
intolerance. Labs show elevated TSH and low free T4. Which is the
most likely diagnosis?
A. Graves disease
B. Hashimoto thyroiditis
C. Subacute thyroiditis
D. Thyroid cancer
Answer: B
The findings of elevated TSH with low free T4 indicate primary
hypothyroidism. Hashimoto thyroiditis is the most common
cause in iodine-sufficient regions and is autoimmune-mediated
destruction of thyroid tissue.
2. A 65-year-old man with long-standing COPD develops increased
PaCO2 with renal compensation. What acid-base disorder is
, present?
A. Metabolic acidosis
B. Respiratory acidosis
C. Metabolic alkalosis
D. Respiratory alkalosis
Answer: B
COPD leads to hypoventilation and CO2 retention, causing
respiratory acidosis. Renal compensation increases bicarbonate
over time.
3. Which vitamin deficiency is associated with peripheral neuropathy
and Wernicke encephalopathy?
A. Vitamin B1
B. Vitamin B6
C. Vitamin B12
D. Vitamin C
Answer: A
Thiamine (B1) deficiency leads to Wernicke-Korsakoff syndrome
and peripheral neuropathy due to impaired glucose metabolism
in neurons.
,4. A patient has a mutation in dystrophin. What condition is most
likely?
A. Myasthenia gravis
B. Duchenne muscular dystrophy
C. Multiple sclerosis
D. Lambert-Eaton syndrome
Answer: B
Dystrophin gene mutations cause Duchenne muscular dystrophy,
characterized by progressive proximal muscle weakness in
childhood.
5. A 30-year-old man has painless hematuria and a renal mass.
Which gene is most commonly mutated?
A. APC
B. VHL
C. RB1
D. BRCA1
Answer: B
Von Hippel-Lindau gene mutation is associated with clear cell
renal cell carcinoma presenting with hematuria and a renal
mass.
, 6. What is the primary site of iron absorption?
A. Stomach
B. Duodenum
C. Jejunum
D. Ileum
Answer: B
Iron is primarily absorbed in the duodenum via DMT1
transporters.
7. Which organism is classically associated with rheumatic fever?
A. Staphylococcus aureus
B. Streptococcus pyogenes
C. Streptococcus pneumoniae
D. Enterococcus faecalis
Answer: B
Group A Streptococcus infection can lead to rheumatic fever due
to molecular mimicry.
8. A child presents with slapped cheek rash. What is the causative
agent?
