COMSAE Final Readiness Predictor Exam
Questions With Correct Answers (Verified
Answers) Plus Rationales 2026 Q&A | Instant
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1. A 65-year-old man presents with exertional chest pain relieved by
rest. Which is the most likely underlying mechanism?
A. Coronary artery spasm
B. Atherosclerotic plaque rupture
C. Fixed coronary atherosclerosis
D. Aortic dissection
Answer: C. Fixed coronary atherosclerosis
Rationale: Stable angina is most commonly caused by fixed
atherosclerotic narrowing of coronary arteries, which limits oxygen
delivery during increased myocardial demand such as exertion. The
pain improves with rest due to reduced demand.
, 2. A patient with COPD is most likely to have which acid-base
disorder?
A. Metabolic alkalosis
B. Respiratory acidosis
C. Metabolic acidosis
D. Respiratory alkalosis
Answer: B. Respiratory acidosis
Rationale: COPD leads to hypoventilation and CO₂ retention, resulting
in elevated PaCO₂ and respiratory acidosis. Chronic compensation may
partially normalize pH.
3. Which structure is primarily responsible for producing surfactant?
A. Type I pneumocytes
B. Type II pneumocytes
C. Alveolar macrophages
D. Clara cells
Answer: B. Type II pneumocytes
Rationale: Type II pneumocytes produce pulmonary surfactant, which
reduces alveolar surface tension and prevents collapse during
expiration.
, 4. A mutation that leads to increased cell proliferation most directly
involves which gene class?
A. Tumor suppressor genes
B. Oncogenes
C. DNA repair genes
D. Structural genes
Answer: B. Oncogenes
Rationale: Oncogenes are mutated or overexpressed proto-oncogenes
that promote cell proliferation and survival.
5. Which vitamin deficiency is associated with peripheral neuropathy
and Wernicke-Korsakoff syndrome?
A. Vitamin B1 (thiamine)
B. Vitamin B6 (pyridoxine)
C. Vitamin B12 (cobalamin)
D. Vitamin E
Answer: A. Vitamin B1 (thiamine)
, Rationale: Thiamine deficiency leads to Wernicke encephalopathy
(confusion, ataxia, ophthalmoplegia) and can progress to Korsakoff
syndrome.
6. A patient with hemolytic anemia is most likely to have which lab
finding?
A. Decreased LDH
B. Increased haptoglobin
C. Increased unconjugated bilirubin
D. Decreased reticulocyte count
Answer: C. Increased unconjugated bilirubin
Rationale: Hemolysis increases breakdown of RBCs, raising
unconjugated bilirubin and LDH while decreasing haptoglobin.
7. Which hormone increases calcium reabsorption in the kidneys and
increases bone resorption?
A. Calcitonin
B. Parathyroid hormone
C. Aldosterone
D. Vitamin D (calcitriol)
Questions With Correct Answers (Verified
Answers) Plus Rationales 2026 Q&A | Instant
Download Pdf
1. A 65-year-old man presents with exertional chest pain relieved by
rest. Which is the most likely underlying mechanism?
A. Coronary artery spasm
B. Atherosclerotic plaque rupture
C. Fixed coronary atherosclerosis
D. Aortic dissection
Answer: C. Fixed coronary atherosclerosis
Rationale: Stable angina is most commonly caused by fixed
atherosclerotic narrowing of coronary arteries, which limits oxygen
delivery during increased myocardial demand such as exertion. The
pain improves with rest due to reduced demand.
, 2. A patient with COPD is most likely to have which acid-base
disorder?
A. Metabolic alkalosis
B. Respiratory acidosis
C. Metabolic acidosis
D. Respiratory alkalosis
Answer: B. Respiratory acidosis
Rationale: COPD leads to hypoventilation and CO₂ retention, resulting
in elevated PaCO₂ and respiratory acidosis. Chronic compensation may
partially normalize pH.
3. Which structure is primarily responsible for producing surfactant?
A. Type I pneumocytes
B. Type II pneumocytes
C. Alveolar macrophages
D. Clara cells
Answer: B. Type II pneumocytes
Rationale: Type II pneumocytes produce pulmonary surfactant, which
reduces alveolar surface tension and prevents collapse during
expiration.
, 4. A mutation that leads to increased cell proliferation most directly
involves which gene class?
A. Tumor suppressor genes
B. Oncogenes
C. DNA repair genes
D. Structural genes
Answer: B. Oncogenes
Rationale: Oncogenes are mutated or overexpressed proto-oncogenes
that promote cell proliferation and survival.
5. Which vitamin deficiency is associated with peripheral neuropathy
and Wernicke-Korsakoff syndrome?
A. Vitamin B1 (thiamine)
B. Vitamin B6 (pyridoxine)
C. Vitamin B12 (cobalamin)
D. Vitamin E
Answer: A. Vitamin B1 (thiamine)
, Rationale: Thiamine deficiency leads to Wernicke encephalopathy
(confusion, ataxia, ophthalmoplegia) and can progress to Korsakoff
syndrome.
6. A patient with hemolytic anemia is most likely to have which lab
finding?
A. Decreased LDH
B. Increased haptoglobin
C. Increased unconjugated bilirubin
D. Decreased reticulocyte count
Answer: C. Increased unconjugated bilirubin
Rationale: Hemolysis increases breakdown of RBCs, raising
unconjugated bilirubin and LDH while decreasing haptoglobin.
7. Which hormone increases calcium reabsorption in the kidneys and
increases bone resorption?
A. Calcitonin
B. Parathyroid hormone
C. Aldosterone
D. Vitamin D (calcitriol)
