Removal of part of the liver leads to the remaining liver cells undergoing compensatory - Answers
Compensatory hyperplasia is an adaptive mechanism that enables certain organs to regenerate. For
example, the removal of part of the liver leads to hyperplasia of the remaining liver cells
(hepatocytes) to compensate for the loss.
Which of the following statements best describes Raynaud disease?
a. An inflammatory disorder of small and medium-size arteries in the feet and sometimes in the hands
b. A neoplastic disorder of the lining of the arteries and veins of the upper extremities
c. A vasospastic disorder of the small arteries and arterioles of the fingers, and less commonly, the
toes
d. An autoimmune disorder of the large arteries and veins of the upper and lower extremities -
Answers c. A vasospastic disorder of the small arteries and arterioles of the fingers, and less
commonly, the toes
A patient is diagnosed with pulmonary disease and elevated pulmonary vascular resistance. Which of
the following heart failures may result from this condition?
a. Right heart failure
b. Left heart failure
c. Low-output failure
d. High-output failure - Answers a. Right heart failure
Exp: Right heart failure is defined as the inability of the right ventricle to provide adequate blood flow
into the pulmonary circulation at a normal central venous pressure. It most often results from the left
heart failure when the increase in left ventricular filling pressure that is reflected back into the
pulmonary circulation is severe enough. As pressure in the pulmonary circulation rises, the resistance
to right ventricular emptying increases.
What physical sign is the result of turbulent blood flow through a vessel?
a. Increased blood pressure during periods of stress
b. Bounding pulse felt on palpation
c. Cyanosis observed on excretion
d. Murmur heard on auscultation - Answers d. Murmur heard on auscultation
Exp: Where flow is obstructed the vessel turns or blood flows over rough surfaces. The flow becomes
turbulent with whorls or eddy currents that produce noise causing a murmur to be heard on
auscultation such as occurs during blood pressure measurement with a sphygomanometer. This
selection is the only option that accurately identifies the physical sign of turbulent vascular blood
flow. pg 1113
Which congenital heart defects occur in trisomy 13, trisomy 18 and down syndrome?
a. Coarctation of the aorta and pulmonary stenosis
b. Tetralogy of Fallot and persistent truncus arteriosus
c. Atrial septal defect and dextrocardia
d. Ventricular septal defect and patent ductus arteriosus - Answers d. Ventricular septal defect and
patent ductus arteriosus
Exp: Congenital heart defects that are related to dysfunction of trisomy 13, trisomy 18 and down
syndrome include VSD and PDA see Table 33-2 The other defects are not associated with dysfunction
of trisomy 13 or 17 and down syndrome. pg 1200
An infant has a continuous machine/type murmur best heard at the left upper sternal border
throughout systole and diastole as well as a bounding pulse and a thrill on palpation. These clinical
findings are consistent with which congenital heart defect?
a. Atrial septal defect
b. Ventricular septal defect
c. Patent ductus arteriosus
d. Atrioventricular canal defect - Answers c. Patent ductus arteriosus
Exp: If pulmonary vascular resistance has fallen then infants with will characteristically have a
continuous machine/type murmur best heard at the left upper sternal border throughout systole and
diastole. If the PDA is significant then the infant also will have bounding pulses an active precordium,
a thrill on palpation and signs and symptoms of pulmonary over circulation. The presentations of the
other congenital heart defects are not consistent with the described the symptoms pages 1203-1204
,Which compensatory mechanism is spontaneously used by children diagnosed with tetralogy of Fallot
to relieve hypoxic spells?
a. Lying on their left side
b. Performing the valsalva maneuver
c. Squatting
d. hyperventilating - Answers c. Squatting
Exp: squatting is a spontaneous compensatory mechanism used by older children to alleviate hypoxic
spells. Squatting and its variants increase systemic resistance while decreasing venous return to the
heart from the inferior vena cava. The other options would not result in these changes. pg 1209
An infant diagnosed with a small patent ductus arteriosus would likely exhibit which symptom?
a. Intermittent murmur
b. Lack of symptoms
c. Need for surgical repair
d. Triad of congenital defects - Answers b. Lack of symptoms
Exp: Infants with a small PDA usually remain asymptomatic. page 1203-1204
Fluid in the pleural space characterizes which condition?
a. Pleural effusion
b. Atelectasis
c. Bronchiectasis
d. Ischemia - Answers a. Pleural Effusion
Exp: Pleural effusion is the presence of fluid in the pleural space. page1254
Which medication classification is generally included in the treatment of silicosis?
a. Corticosteroids
b. Antiboitics
c. Bronchodilators
d. Expectorants - Answers a. Corticosteroids
Exp: No specific treatment exists for silicosis, although corticosteroids may produce some
improvement in the early, more acute stages. page 1259
The risk for respiratory distress syndrome (RDS) decreases for premature infants when they are born
between how many weeks of gestation?
a. 16 and 24
b. 20 and 24
c. 24 and 30
d. 30 and 36 - Answers d. 30 and 36
Exp: Surfactant is secreted into fetal airways between 30 and 36 weeks. The other options are not
true regarding the timeframe when the risk for RDS decreases. page 1292
What is the chief predisposing factor for respiratory distress syndrome (RDS) of the newborn?
a. Low birth weight
b. Alcohol consumption during pregnanc
c. Premature birth
d. Smoking during pregnancy - Answers a. Premature birth
Exp: RDS of the newborn, also known as hyaline membrane disease (HMD), is a major cause of
morbidity and mortality in premature newborns. page 1301
What is the primary cause of respiratory distress syndrome (RDS) of the newborn?
a. Immature immune system
b. Small alveoli
c. Surfactant deficiency
d. Anemia - Answers c. Surfactant deficiency
Exp: RDS is primarily caused by surfactant deficiency and secondarily by a deficiency in alveolar
surface area for gas exchange. page 1301
What is the primary problem resulting from respiratory distress syndrome (RDS) of the newborn?
,a. Consolidation
b. Pulmonary edema
c. Atelectasis
d. Bronchiolar plugging - Answers c. Atelectasis
Exp: The primary problem is atelectasis, which causes significant hypoxemia and is difficult for the
neonate to overcome because a significant negative inspiratory pressure is required to open the
alveoli with each breath. None of the other options are considered a primary problem associated with
RDS. page 1301
Which statement best describes cystic fibrosis?
a. Obstructive airway disease characterized by reversible airflow obstruction, bronchial
hyperreactivity, and inflammation
b. Respiratory disease characterized by severe hypoxemia, decreased pulmonary compliance, and
diffuse densities on chest X-ray imaging
c. P!ulmonary disorder involving an abnormal expression of a protein-producing viscous mucus that
obstructs the airways, pancreas, sweat ducts, and vas deferens
d. Pulmonary disorder characterized by atelectasis and increased pulmonary
resistance as a result of a surfactant deficiency - Answers c. Pulmonary disorder involving an
abnormal expression of a protein-producing viscous mucus that obstructs the airways, pancreas,
sweat ducts, and vas deferens
Exp: Cystic fibrosis is best described as a pulmonary disorder involving an abnormal expression of a
protein-producing viscous mucus that obstructs the airways, pancreas, sweat ducts, and vas deferens.
This selection is the only option that accurately describes cystic fibrosis. pages 1310-1311
Cystic fibrosis is caused by which process?
a. Autosomal recessive inheritance
b. Autosomal dominant inheritance
c. Infection
d. Malignancy - Answers a. Autosomal recessive inheritance
Exp: Cystic fibrosis is an autosomal recessive inherited disorder that is associated with defective
epithelial ion transport. None of the other options cause cystic fibrosis. page 1310
What are the abnormalities in cytokines found in children with cystic fibrosis (CF)?
a. Deficit of interleukin(IL)-1 and an excess of IL-4, IL-12, and interferon-alpha (IFN-α)
b. Deficit of IL-6 and an excess of IL-2, IL-8 and granulocyte colony-stimulating factor (G-CSF)
c. Deficit of IL-10 and an excess of IL-1, IL-8 and TNF α
d. Deficit of IL-3 and an excess of IL-14, IL- 24 & colony-stimulating factor (CSF) - Answers c. Deficit of
IL-10 and an excess of IL-1 , IL-8 and TNF α
Exp: Abnormal cytokine profiles have been documented in CF airway fluids, including deficient IL-10
and excessive IL-1, IL-8, and TNF-α, all changes conducive to promoting inflammation. pages 1311-12
Which hormone is required for water to be reabsorbed in the distal tubule and collecting duct?
a. Antidiuretic hormone
b. Aldosterone
c. Cortisol
d. Adrenocorticotropin hormone - Answers a. Antidiuretic hormone
Exp: Antidiuretic hormone is required for water to be reabsorbed in the distal tubule and collecting
duct. The later, straight segment of the distal tubule and the collecting duct are permeable to water
as controlled by antidiuretic hormone. The other options are not involved in this process. page 1331
The concentration of the final urine is determined by antidiuretic hormone (ADH), which is secreted
by which gland?
, a. Posterior pituitary
b. Thyroid
c. Parathyroid
d. Anterior pituitary - Answers a. Posterior pituitary
Exp: ADH which is secreted from the posterior pituitary gland, controls the concentration of the final
urine. Pages 1332 and 1333
What is the most common cause of uncomplicated urinary tract infections?
a. Staphylococcus
b. Klebsiella
c. Proteus
d. Escherichia coli - Answers d. Escherichia coli ; The most common infecting microorganisms are
uropathic strains of E. coli (80% to 85%). page 1350
Which clinical manifestations of a urinary tract infection may be demonstrated in an 85-year-old
individual?
a. Confusion and poorly localized abdominal discomfort
b. Dysuria, frequency, and suprapubic pain
c. Hematuria and flank pain
d. Pyuria, urgency, and frequency - Answers a. Confusion and poorly localized abdominal discomfort
Exp: Older adults with cystitis may demonstrate confusion or vague abdominal discomfort or
otherwise be asymptomatic. page 1351
Pyelonephritis is usually caused by which type of organism?
a. Bacteria
b. Fungi
c. Viruses
d. Parasite - Answers a. Bacteria
Exp: Pyelonephritis is usually caused by the bacteria Escherichia coli, Proteus, or Pseudomonas. pages
1351-52
A patient exhibits symptoms including hematuria with red blood cell casts and proteinuria exceeding
3 to 5 g/ day with albumin as the major protein. These data suggest the presence of which disorder?
a. Cystitis
b. Chronic pyelonephritis
c. Glomerulonephritis
d. Nephrotic syndrome - Answers c. Glomerulonephritis
Exp: The data suggest the patient has the disorder known as glomerulonephritis. Two major changes
distinctive of more severe glomerulonephritis are (1) hematuria with red blood cell casts and (2)
proteinuria exceeding 3-5 g/ day with albumin as the major protein. These symptoms do not support
the diagnosis of the other options. page 1357
How are glucose and insulin used to treat hyperkalemia associated with acute renal failure?
a. Glucose has an osmotic effect, which attracts water and sodium resulting in more dilute blood and
a lower potassium concentration.
b. When insulin transports glucose into the cell, it also carries potassium with it.
c. Potassium attaches to receptors on the cell membrane of glucose and is carried into the cell.
d. Increasing insulin causes ketoacidosis, which causes potassium to move into the cell in exchange for
hydrogen - Answers b. When insulin transports glucose into the cell, it also carries potassium with it.
Exp: This selection is the only option that accurately describes glucose metabolism causing potassium
to move to the intracellular fluid; insulin infusions therefore can be effective in shifting potassium
from the extracellular to intracellular space, along with the transport of glucose. page 1363
________ is used to correct the chronic anemia associated with chronic renal failure