NR 565 - ADVANCED PHARMACOLOGY
MIDTERM EXAM – CHAMBERLAIN STUDY
GUIDE WITH CORRECT VERIFIED
ANSWERS GRADED A+ || 100%
GUARANTEED PASS NEWEST VERSION
Baseline data for Methotrexate (DMARD) - Answer chest x-ray, emphasis on
pulm and GI status
which DMARD needs ophthalmologic and cardiac exam? - Answer
hydroxychloroquine
black box warning for Raloxifene - Answer risk for venous thromboembolic
events (DVT, PE, stroke)
Behaviors that should predict controlled substance addiction - Answer
reinforcing properties of drugs - pleasurable (euphoria) or reduce unpleasant
experience (reduce anxiety and stress
physical dependence
physiological dependence (well-being depends on drug)
social factors (peer pressure)
drug availability (Drugs in hospitals - reason for nurses or pharmacist abuse)
vulnerability of individual
impulsive
low tolerance for frustration
rebellious against social norms
,depressive, anxiety, and anti-social personality disorders
abuse other drugs
Treatment of chronic pain with pregabalin - Answer adjuvant analgesic for
neuropathic pain
Effective in diabetic neuropathy, seizures, central neuropathy, postherpetic
neuralgia, and fibromyalgia
adverse effects of pregabalin - Answer Sedation/drowsy, dizziness, and ataxia,
blurred vision, difficulty thinking
GI bleeding is linked to - Answer COX-2 inhibitors and NSAID
patient education with colchicine - Answer only when needed to relieve an
attack: Start taking this medicine at the first sign of the attack for best results. Stop
taking this medicine as soon as the pain is relieved or at the first sign of nausea,
vomiting, stomach pain, or diarrhea.
longer you wait to start with attack, less effective it might be
Which drugs are high risk in pregnancy with RA? - Answer methotrexate
leflunomide
biologics: anti-TNF agents, rituximab and abatacept (end in -mab)
Which drugs are safe for pregnancy with RA ? - Answer NSAIDs,
corticosteroids, plus several DMARDs, including sulfasalazine and
hydroxychloroquine
,NSAID black box warning - Answer NSAIDs may increase the risk for
myocardial infarction, stroke, and other thromboembolic events. NSAIDs increase
the risk for dangerous gastrointestinal adverse effects such as bleeding, ulceration,
and perforation.
Drug interactions with Allopurinol - Answer Mercaptopurine and azathioprine
(immunosuppressants)
warfarin
Theophylline
Ampicillin
therapeutic response for methotrexate - Answer If you are taking methotrexate
to treat rheumatoid arthritis, it may take 3 to 6 weeks for your symptoms to begin
to improve, and 12 weeks or longer for you to feel the full benefit of methotrexate.
Continue to take methotrexate even if you feel well.
adverse effects for bisphosphonates - Answer osteonecrosis of the jaw and hip
fracture, Esophagitis
When are bisphosphonates contraindicated? - Answer esophageal disorders
cr below 30 -35
therapeutic action of NSAIDS - Answer relieve pain/discomfort, reduce
inflammation, and bring down a high temperature.
MOA NSAIDS - Answer inhibition of the enzyme cyclooxygenase (COX),
decreased synthesis of prostaglandins
, Women who have hypertension and osteoporosis should be prescribed which
antihypertensive? - Answer thiazide diuretic
Drug interactions with NSAIDS - Answer other NSAIDS, alcohol, warfarin
(blood thinners), ACE inhibitors and diuretics
Rules for prescribing schedule II drugs - Answer written in ink, can write in
emergency cases but must submit within 72 hour, no refills, can have multiple
scripts by different MDs
Depends on state
During what trimester is a pregnant woman most at risk for adverse drug reactions
with potential long term consequences? - Answer 1st trimester (fetus most at
risk d/t rapid growth)
What is BEERS criteria? - Answer Recommendations of medications
inappropriate for elderly (65 and older), prescriber ultimately decides
What is the CYP450 (cytochrome P450) - Answer liver enzyme system where
medications are metabolized, can either be inducers or inhibitors and create drug-
drug interactions
CYP450 inducers - Answer Speed up metabolism of drugs (drug is cleared
faster), drug has lesser effect (decrease blood levels of drug), elevate CYP450
enzymes
CYP450 inducers pneumonic - Answer "Bullshit Crap GPS INDUCES rage"
MIDTERM EXAM – CHAMBERLAIN STUDY
GUIDE WITH CORRECT VERIFIED
ANSWERS GRADED A+ || 100%
GUARANTEED PASS NEWEST VERSION
Baseline data for Methotrexate (DMARD) - Answer chest x-ray, emphasis on
pulm and GI status
which DMARD needs ophthalmologic and cardiac exam? - Answer
hydroxychloroquine
black box warning for Raloxifene - Answer risk for venous thromboembolic
events (DVT, PE, stroke)
Behaviors that should predict controlled substance addiction - Answer
reinforcing properties of drugs - pleasurable (euphoria) or reduce unpleasant
experience (reduce anxiety and stress
physical dependence
physiological dependence (well-being depends on drug)
social factors (peer pressure)
drug availability (Drugs in hospitals - reason for nurses or pharmacist abuse)
vulnerability of individual
impulsive
low tolerance for frustration
rebellious against social norms
,depressive, anxiety, and anti-social personality disorders
abuse other drugs
Treatment of chronic pain with pregabalin - Answer adjuvant analgesic for
neuropathic pain
Effective in diabetic neuropathy, seizures, central neuropathy, postherpetic
neuralgia, and fibromyalgia
adverse effects of pregabalin - Answer Sedation/drowsy, dizziness, and ataxia,
blurred vision, difficulty thinking
GI bleeding is linked to - Answer COX-2 inhibitors and NSAID
patient education with colchicine - Answer only when needed to relieve an
attack: Start taking this medicine at the first sign of the attack for best results. Stop
taking this medicine as soon as the pain is relieved or at the first sign of nausea,
vomiting, stomach pain, or diarrhea.
longer you wait to start with attack, less effective it might be
Which drugs are high risk in pregnancy with RA? - Answer methotrexate
leflunomide
biologics: anti-TNF agents, rituximab and abatacept (end in -mab)
Which drugs are safe for pregnancy with RA ? - Answer NSAIDs,
corticosteroids, plus several DMARDs, including sulfasalazine and
hydroxychloroquine
,NSAID black box warning - Answer NSAIDs may increase the risk for
myocardial infarction, stroke, and other thromboembolic events. NSAIDs increase
the risk for dangerous gastrointestinal adverse effects such as bleeding, ulceration,
and perforation.
Drug interactions with Allopurinol - Answer Mercaptopurine and azathioprine
(immunosuppressants)
warfarin
Theophylline
Ampicillin
therapeutic response for methotrexate - Answer If you are taking methotrexate
to treat rheumatoid arthritis, it may take 3 to 6 weeks for your symptoms to begin
to improve, and 12 weeks or longer for you to feel the full benefit of methotrexate.
Continue to take methotrexate even if you feel well.
adverse effects for bisphosphonates - Answer osteonecrosis of the jaw and hip
fracture, Esophagitis
When are bisphosphonates contraindicated? - Answer esophageal disorders
cr below 30 -35
therapeutic action of NSAIDS - Answer relieve pain/discomfort, reduce
inflammation, and bring down a high temperature.
MOA NSAIDS - Answer inhibition of the enzyme cyclooxygenase (COX),
decreased synthesis of prostaglandins
, Women who have hypertension and osteoporosis should be prescribed which
antihypertensive? - Answer thiazide diuretic
Drug interactions with NSAIDS - Answer other NSAIDS, alcohol, warfarin
(blood thinners), ACE inhibitors and diuretics
Rules for prescribing schedule II drugs - Answer written in ink, can write in
emergency cases but must submit within 72 hour, no refills, can have multiple
scripts by different MDs
Depends on state
During what trimester is a pregnant woman most at risk for adverse drug reactions
with potential long term consequences? - Answer 1st trimester (fetus most at
risk d/t rapid growth)
What is BEERS criteria? - Answer Recommendations of medications
inappropriate for elderly (65 and older), prescriber ultimately decides
What is the CYP450 (cytochrome P450) - Answer liver enzyme system where
medications are metabolized, can either be inducers or inhibitors and create drug-
drug interactions
CYP450 inducers - Answer Speed up metabolism of drugs (drug is cleared
faster), drug has lesser effect (decrease blood levels of drug), elevate CYP450
enzymes
CYP450 inducers pneumonic - Answer "Bullshit Crap GPS INDUCES rage"
