ELITE COMPREHENSIVE
BIOPHARMACEUTICS (VIOLET) – PACOP
COMPREHENSIVE EXAMINATION
Drug Absorption, Bioavailability and Drug
Delivery Exam|| Questions and Answers
Spring Examination May 2026
Which of the following is not true regarding the purpose of tablet coating?
A. Improves palatability
B. Improve aesthetic value of tablet
C. Improve stability
D. Improve in-vivo degradation
E. None of these
✓ D
A surface active agent that facilitates the absorption of lipophilic drug or water insoluble
drugs
A. Bile
B. Albumin
1
C. Renin
Page
D. Gastric acid
, E. None of these
✓ A
Phase 2 metabolism that protects the body against chemically reactive metabolites
A. Sulfate conjugation
B. Glutathione conjugation
C. Methylation
D. Acetylation
E. Glycine conjugation
✓ B
All of the following listed below are processes of drug excretion, EXCEPT:
A. Glomerular filtration
B. Active secretion
C. Tubular secretion
D. Tubular reabsorption
E. None of these
✓ E
It is the basic functional unit of the kidney
A. Glomerulus
B. Loop of henle
2
C. Nephron
Page
D. Collecting tubule
, E. None of these
✓ C
Creatinine clearance of a patient with kidney failure
A. 60-89 mL
B. 30-59 mL
C. 15-29 mL
D. <15 mL
None of these
✓ D
Which of the following drugs listed below will increase its clearance at alkaline urine?
I. Amphetamine
II. Imipramine
III. Barbiturates
IV. Salicylic acid
A. I and II
B. II and III
C. III and IV
D. All of these
E. None of these
✓ C
3
Page
, Which of the following correctly describes ion trapping
A. Changing the pH of urine used to facilitate the elimination of drug that proved to be
toxic to a patient or has been taken in overdosed amount
B. Administration of acidic drug to neutralize am alkaline poison in the stomach
C. Alkalinizing the urine to facilitate excretion of weakly basic drugs
D. A and C
E. None of these
✓ A
Discipline that applies Pharmacokinetic concepts and principles in humans in order to
design individualized dosage regimens that optimize the therapeutic response of a
medication while minimizing the chance of an adverse drug reaction
A. Clinical toxicology
B. Clinical pharmacy
C. Clinical Pharmacokinetics
D. Pharmacotherapeutics
E. None of these
✓ C
Chemical conversion of the drug molecule, usually by an enzymatically mediated
reaction, into another chemical entity referred to as a metabolite
A. Absorption
B. Distribution
C. Metabolism
4
D. Excretion
Page
None of these
BIOPHARMACEUTICS (VIOLET) – PACOP
COMPREHENSIVE EXAMINATION
Drug Absorption, Bioavailability and Drug
Delivery Exam|| Questions and Answers
Spring Examination May 2026
Which of the following is not true regarding the purpose of tablet coating?
A. Improves palatability
B. Improve aesthetic value of tablet
C. Improve stability
D. Improve in-vivo degradation
E. None of these
✓ D
A surface active agent that facilitates the absorption of lipophilic drug or water insoluble
drugs
A. Bile
B. Albumin
1
C. Renin
Page
D. Gastric acid
, E. None of these
✓ A
Phase 2 metabolism that protects the body against chemically reactive metabolites
A. Sulfate conjugation
B. Glutathione conjugation
C. Methylation
D. Acetylation
E. Glycine conjugation
✓ B
All of the following listed below are processes of drug excretion, EXCEPT:
A. Glomerular filtration
B. Active secretion
C. Tubular secretion
D. Tubular reabsorption
E. None of these
✓ E
It is the basic functional unit of the kidney
A. Glomerulus
B. Loop of henle
2
C. Nephron
Page
D. Collecting tubule
, E. None of these
✓ C
Creatinine clearance of a patient with kidney failure
A. 60-89 mL
B. 30-59 mL
C. 15-29 mL
D. <15 mL
None of these
✓ D
Which of the following drugs listed below will increase its clearance at alkaline urine?
I. Amphetamine
II. Imipramine
III. Barbiturates
IV. Salicylic acid
A. I and II
B. II and III
C. III and IV
D. All of these
E. None of these
✓ C
3
Page
, Which of the following correctly describes ion trapping
A. Changing the pH of urine used to facilitate the elimination of drug that proved to be
toxic to a patient or has been taken in overdosed amount
B. Administration of acidic drug to neutralize am alkaline poison in the stomach
C. Alkalinizing the urine to facilitate excretion of weakly basic drugs
D. A and C
E. None of these
✓ A
Discipline that applies Pharmacokinetic concepts and principles in humans in order to
design individualized dosage regimens that optimize the therapeutic response of a
medication while minimizing the chance of an adverse drug reaction
A. Clinical toxicology
B. Clinical pharmacy
C. Clinical Pharmacokinetics
D. Pharmacotherapeutics
E. None of these
✓ C
Chemical conversion of the drug molecule, usually by an enzymatically mediated
reaction, into another chemical entity referred to as a metabolite
A. Absorption
B. Distribution
C. Metabolism
4
D. Excretion
Page
None of these
