COMSAE Test Questions And Correct Answers
(Verified Answers) 2026
CD4 AND CD8 T LYMPHOCYTES ARE NORMALLY FOUND IN - CORRECT ANSWER -
thymic medulla?
Hypersensitivity: - CORRECT ANSWER -4 types anaphylactic and atopic (type I); cytotoxic (ab
mediated type II); Immune complex (type III) Delayed (cell mediated, type IV)
ACID!!!
TYPE I HSR
I=IgE - CORRECT ANSWER -Anaphylactic and atopic--free ag cross link IgE!!! on
presensitized mast cells and basophils>> vasoactive amines that act at post capillary venues (like
histamine);
rapid develop after antigen exposure bc of preformed antibody; delayed phase results from mast
cells and basophils releasing cytokines that induce cellular inflamm
Type I = first and fast - CORRECT ANSWER -Type I II and III are all antibody mediated
Test: skin test or blood test (ELISA) for allergen specific IgE;
Ex: anaphylaxis (food, drug, or bee sting)
Interpretation of Type I - CORRECT ANSWER -Allergen binds specific allergen IgE's on Mast
cells and basophis>>leading to degranulation "" (vasoactive amines that act @ post cap venules)
Type II HSR - CORRECT ANSWER -Antibodies bind to cell-surface Ags>> cell destruction,
inflammation, and cellular dysfunction
Cell destruction - CORRECT ANSWER -cell is opsonized (coated) by Abs, leading to either:
1. phagocytosis and/or activation of complement system
, 2. NK cell killing (ab dependent cellular cytotoxicity)
**complement or cytotoxicity!!**
Inflammation--bind of abs to cell surfaces>>active of complement system and Fc
receptormediated inflammation;
Cell dysfunction: abs bind to cell surface receptors> abnormal blockade or active of downstream
process
Direct Coombs Test - CORRECT ANSWER -For type II HSR
direct Coombs detects abs attached directly to the RBC surface
Indirect Coombs test--detect presence of unbound antibodies in the serum
Examples type II HSR Cellular destruction - CORRECT ANSWER -autoimmune-hemolytic
anemia
immune thrombocytopenia purpura
transfusion reactions
hemolytic disease of the newborn
Inflammation type II HSR - CORRECT ANSWER -Examples:
Goodpasture syndrome, rheumatic fever, hyper acute transplant rejection
Cellular dysfunction type II - CORRECT ANSWER -myasthenia graves, Graves disease
Type III HSR - CORRECT ANSWER -Immune complex--Ag-antibody IgG complexes activate
complement which attracts neutrophils> release lysosomal enzymes; can be assoc w/ vasculitis
and systemic manifestation
In type III immagine immune complex as three things stuck together - CORRECT ANSWER -
Antigen antibody complement
(Verified Answers) 2026
CD4 AND CD8 T LYMPHOCYTES ARE NORMALLY FOUND IN - CORRECT ANSWER -
thymic medulla?
Hypersensitivity: - CORRECT ANSWER -4 types anaphylactic and atopic (type I); cytotoxic (ab
mediated type II); Immune complex (type III) Delayed (cell mediated, type IV)
ACID!!!
TYPE I HSR
I=IgE - CORRECT ANSWER -Anaphylactic and atopic--free ag cross link IgE!!! on
presensitized mast cells and basophils>> vasoactive amines that act at post capillary venues (like
histamine);
rapid develop after antigen exposure bc of preformed antibody; delayed phase results from mast
cells and basophils releasing cytokines that induce cellular inflamm
Type I = first and fast - CORRECT ANSWER -Type I II and III are all antibody mediated
Test: skin test or blood test (ELISA) for allergen specific IgE;
Ex: anaphylaxis (food, drug, or bee sting)
Interpretation of Type I - CORRECT ANSWER -Allergen binds specific allergen IgE's on Mast
cells and basophis>>leading to degranulation "" (vasoactive amines that act @ post cap venules)
Type II HSR - CORRECT ANSWER -Antibodies bind to cell-surface Ags>> cell destruction,
inflammation, and cellular dysfunction
Cell destruction - CORRECT ANSWER -cell is opsonized (coated) by Abs, leading to either:
1. phagocytosis and/or activation of complement system
, 2. NK cell killing (ab dependent cellular cytotoxicity)
**complement or cytotoxicity!!**
Inflammation--bind of abs to cell surfaces>>active of complement system and Fc
receptormediated inflammation;
Cell dysfunction: abs bind to cell surface receptors> abnormal blockade or active of downstream
process
Direct Coombs Test - CORRECT ANSWER -For type II HSR
direct Coombs detects abs attached directly to the RBC surface
Indirect Coombs test--detect presence of unbound antibodies in the serum
Examples type II HSR Cellular destruction - CORRECT ANSWER -autoimmune-hemolytic
anemia
immune thrombocytopenia purpura
transfusion reactions
hemolytic disease of the newborn
Inflammation type II HSR - CORRECT ANSWER -Examples:
Goodpasture syndrome, rheumatic fever, hyper acute transplant rejection
Cellular dysfunction type II - CORRECT ANSWER -myasthenia graves, Graves disease
Type III HSR - CORRECT ANSWER -Immune complex--Ag-antibody IgG complexes activate
complement which attracts neutrophils> release lysosomal enzymes; can be assoc w/ vasculitis
and systemic manifestation
In type III immagine immune complex as three things stuck together - CORRECT ANSWER -
Antigen antibody complement
