ELITE COMPREHENSIVE
LEHNE PHARMACOLOGY MASTER EXAM REVIEW
HIGH-YIELD MULTIPLE-CHOICE QUESTIONS WITH
CLINICAL RATIONALES|| QUESTIONS AND ANSWERS
Spring Examination May 2026
A nurse is preparing to give an oral dose of drug X to treat a patient's high blood
pressure. After giving the drug, the nurse finds that it reduces the blood pressure
without serious harmful effects, but it also causes the patient to have nausea and a
headache. Based on this information, which property of an ideal drug is this drug
lacking?
Effectiveness
Safety
Selectivity
Ease of administration
✓ Selectivity
✓ The drug is effective in lowering the blood pressure and safe in that it
does not cause harmful effects. However, as do most drugs, it causes
other effects besides the one response desired; therefore, it lacks
selectivity. The oral form provides ease of administration.
1
Page
, The nurse is preparing to give a drug with certain properties. Which property of the drug
is the most compelling indication that it should not be given?
The drug produces an unwanted side effect.
The drug is difficult to administer.
The drug's effects are reversible.
The drug is not effective for its intended purpose.
✓ The drug is not effective for its intended purpose
✓ f a drug is not effective, there is no justification for giving it. Some
drugs may be given even though they produce unwanted side effects
or are difficult to administer. Reversible action is a desired property
for most drugs.
Why is it important for drugs to have ease of administration?
Fewer administration errors
Less risk of side effects
Greater chemical stability
Greater likelihood of reversibility
✓ Fewer Admin errors
✓ Ease of administration increases convenience and adherence and
can reduce administration errors. Ease of administration is not related
to side effects, chemical stability, or reversibility.
2
Page
, The nurse teaches a patient not to consume alcohol with nitroglycerine, because the
blood pressure often drops significantly when nitroglycerine is taken with alcohol. Which
drug property does this illustrate?
Chemical instability
Drug interaction
Reversible action
Drug selectivity
✓ Drug interaction
✓ When two or more drugs are taken together, they can interact,
causing either increased or decreased drug responses. In this case,
alcohol would increase the nitroglycerine response. Chemical
instability, reversible action, and drug selectivity are not related to this
situation.
When studying the impact a drug has on the body, the nurse is reviewing what?
The drug's pharmacokinetics
The drug's selectivity
The drug's pharmacodynamics
The drug's predictability
✓ Pharmacodynamics
✓ Pharmacodynamics can be thought of as the impact of drugs on the
body. Pharmacokinetics describes the movement of drugs through
the body. Selectivity is the ability of a drug to elicit only the response
3
for which it is given. Predictability is the degree of certainty about how
Page
a patient will respond to a certain drug.
LEHNE PHARMACOLOGY MASTER EXAM REVIEW
HIGH-YIELD MULTIPLE-CHOICE QUESTIONS WITH
CLINICAL RATIONALES|| QUESTIONS AND ANSWERS
Spring Examination May 2026
A nurse is preparing to give an oral dose of drug X to treat a patient's high blood
pressure. After giving the drug, the nurse finds that it reduces the blood pressure
without serious harmful effects, but it also causes the patient to have nausea and a
headache. Based on this information, which property of an ideal drug is this drug
lacking?
Effectiveness
Safety
Selectivity
Ease of administration
✓ Selectivity
✓ The drug is effective in lowering the blood pressure and safe in that it
does not cause harmful effects. However, as do most drugs, it causes
other effects besides the one response desired; therefore, it lacks
selectivity. The oral form provides ease of administration.
1
Page
, The nurse is preparing to give a drug with certain properties. Which property of the drug
is the most compelling indication that it should not be given?
The drug produces an unwanted side effect.
The drug is difficult to administer.
The drug's effects are reversible.
The drug is not effective for its intended purpose.
✓ The drug is not effective for its intended purpose
✓ f a drug is not effective, there is no justification for giving it. Some
drugs may be given even though they produce unwanted side effects
or are difficult to administer. Reversible action is a desired property
for most drugs.
Why is it important for drugs to have ease of administration?
Fewer administration errors
Less risk of side effects
Greater chemical stability
Greater likelihood of reversibility
✓ Fewer Admin errors
✓ Ease of administration increases convenience and adherence and
can reduce administration errors. Ease of administration is not related
to side effects, chemical stability, or reversibility.
2
Page
, The nurse teaches a patient not to consume alcohol with nitroglycerine, because the
blood pressure often drops significantly when nitroglycerine is taken with alcohol. Which
drug property does this illustrate?
Chemical instability
Drug interaction
Reversible action
Drug selectivity
✓ Drug interaction
✓ When two or more drugs are taken together, they can interact,
causing either increased or decreased drug responses. In this case,
alcohol would increase the nitroglycerine response. Chemical
instability, reversible action, and drug selectivity are not related to this
situation.
When studying the impact a drug has on the body, the nurse is reviewing what?
The drug's pharmacokinetics
The drug's selectivity
The drug's pharmacodynamics
The drug's predictability
✓ Pharmacodynamics
✓ Pharmacodynamics can be thought of as the impact of drugs on the
body. Pharmacokinetics describes the movement of drugs through
the body. Selectivity is the ability of a drug to elicit only the response
3
for which it is given. Predictability is the degree of certainty about how
Page
a patient will respond to a certain drug.
