BIOCHEMISTRY
ENZYME INHIBITION
, Inhibitors are molecules that => resemble the
substrate(s) or product(s) and bind to => active site =>
thus => they interfere with catalysis => slowing or
halting enzymatic reactions.
Many drugs are => reversible enzyme inhibitors.
They have their physiological effect by => decreasing
=> the activity of a specific enzyme.
For example, aspirin (acetylsalicylate) => inhibits the
enzyme that catalyzes the first step in the synthesis of
prostaglandins => compounds involved in many
processes => including some that produce pain.
, Concentration of inhibitor needed => to inhibit
enzyme => depends on how tightly inhibitor
binds to the enzyme.
Inhibition constant (Ki) is used to describe =>
how tightly an inhibitor binds to an enzyme.
Types of Inhibitors
There are two broad classes of enzyme inhibitors:
• Irreversible
• Reversible
ENZYME INHIBITION
, Inhibitors are molecules that => resemble the
substrate(s) or product(s) and bind to => active site =>
thus => they interfere with catalysis => slowing or
halting enzymatic reactions.
Many drugs are => reversible enzyme inhibitors.
They have their physiological effect by => decreasing
=> the activity of a specific enzyme.
For example, aspirin (acetylsalicylate) => inhibits the
enzyme that catalyzes the first step in the synthesis of
prostaglandins => compounds involved in many
processes => including some that produce pain.
, Concentration of inhibitor needed => to inhibit
enzyme => depends on how tightly inhibitor
binds to the enzyme.
Inhibition constant (Ki) is used to describe =>
how tightly an inhibitor binds to an enzyme.
Types of Inhibitors
There are two broad classes of enzyme inhibitors:
• Irreversible
• Reversible
