1. A patient with COPD and chronic hypercapnia is found unresponsive. ABG:
pH 7.28, PaCO₂ 68 mm Hg, HCO₃ 32 mEq/L. Which interpretation is correct?
o A) Uncompensated respiratory acidosis with hypoxemia
o B) Partially compensated respiratory acidosis with renal compensation
o C) Fully compensated metabolic alkalosis
o D) Mixed respiratory acidosis and metabolic alkalosis
Answer: B (pH still low but HCO₃ elevated — kidneys compensating
partially)
2. A patient with aspirin overdose initially presents with tachypnea and
respiratory alkalosis. Twelve hours later, ABG shows pH 7.30, HCO₃ 14
mEq/L, PaCO₂ 30 mm Hg. What has occurred?
o A) Full compensation of respiratory alkalosis
o B) Development of metabolic acidosis with partial respiratory
compensation
o C) Uncompensated metabolic alkalosis
o D) Respiratory acidosis from hypoventilation
Answer: B (Salicylate toxicity causes mixed picture; now metabolic acidosis
with respiratory compensation)
3. A patient on a loop diuretic develops lethargy and confusion. ABG: pH 7.50,
PaCO₂ 48 mm Hg, HCO₃ 34 mEq/L. What is the most likely primary disorder
and compensation?
o A) Metabolic alkalosis with partial respiratory compensation
o B) Respiratory acidosis with renal compensation
o C) Metabolic acidosis with respiratory compensation
o D) Mixed metabolic and respiratory alkalosis
Answer: A (pH high, HCO₃ high → metabolic alkalosis; PaCO₂ elevated but
not enough to normalize pH)
4. A patient with severe diarrhea has ABG: pH 7.32, HCO₃ 18 mEq/L, PaCO₂ 35
mm Hg. The nurse notes the patient is alert with Kussmaul respirations.
What is the best interpretation?
o A) Uncompensated metabolic acidosis
o B) Partially compensated respiratory alkalosis
o C) Compensated metabolic acidosis
o D) Uncompensated respiratory acidosis
Answer: A (pH low, HCO₃ low, PaCO₂ normal — no compensation yet)
, 5. Which patient is at highest risk for developing acute respiratory acidosis
within the next hour?
o A) Patient with anxiety disorder hyperventilating
o B) Postoperative patient receiving high-flow oxygen
o C) Patient with opioid overdose and respiratory rate of 6
o D) Patient with diabetic ketoacidosis and vomiting
Answer: C (Opioid-induced hypoventilation → acute CO₂ retention)
6. A patient on chemotherapy for leukemia develops painful oral lesions with
white patches that bleed when scraped. The patient refuses to eat or drink.
What is the priority nursing intervention?
o A) Administer IV antibiotics
o B) Provide topical antifungals and pain management before meals
o C) Insert an NG tube for feeding
o D) Encourage commercial alcohol-based mouthwash
Answer: B (Pain control and antifungal first; maintain nutrition orally if
possible)
7. A patient with HIV presents with fuzzy white patches on the lateral tongue
that cannot be scraped off. This is most consistent with:
o A) Candidiasis
o B) Hairy leukoplakia
o C) Erythroplakia
o D) Aphthous stomatitis
Answer: B (Hairy leukoplakia — associated with EBV in
immunocompromised)
8. A patient with xerostomia from head and neck radiation reports difficulty
swallowing and a sensation of food sticking in the throat. What is the most
serious immediate concern?
o A) Dental caries
o B) Aspiration pneumonia
o C) Oral candidiasis
o D) Malnutrition
Answer: B (Dysphagia + dry mouth increases aspiration risk)
9. A patient with acute sialadenitis of the parotid gland has facial asymmetry
when asked to smile. What is the nurse’s priority action?
o A) Apply warm compresses
o B) Administer IV antibiotics
o C) Assess facial nerve function and notify provider