,Nausea/Vomiting
Causes
- ingestion of substances/drugs (noxious stimulants)
(ETOH, abx (Pcn/erythromycin) chemotherapy, digoxin, theophylline)
- Conditions: MI, pregnancy, GI bug
- GI disorders
- Cannabis Hyperemesis
- Neurological processes
- Odors, gruesome sights
- POVN (post op vomiting/nausea) -> higher with inhaled nitrous
** anticipatory nausea and vomiting (previous bouts, likely to reoccur w/surgery)
Risk factors: children, younger females, elderly
Arcangelo et al. (2017). Gastroesophageal reflux disease. Wolters Kluwer.
, Histamine
Receptor
Acetylcholine Head Trauma
Vestibular System Tumor
Receptor
Emotions
Pain
Smells
Acetylcholine Gorey Sights
Receptor Fear
Histamine
Receptor
Medulla Oblongata- CHEMOTHERAPY TRIGGER ZONE (CTZ)
CTZ
Chemoreceptor
- hypersensitive to
Trigger Zone hormones, electrolyte
(outside Blood
Muscarinic/Serotonin imbalances and drugs
Brain Barrier)
Receptor Dopamine 2 Receptor
Muscarinic/Serotonin Vomiting that cross BBB
Receptor Center ie: digoxin toxicity
Acetylcholine
Receptor
Histamine - Kicked in
Receptor
groin or
injury to
stomach Pathophysiology Nausea/Vomiting
, Stimulation of Vomiting Center
Vomiting Center
and Stomach
• Causes the following actions
- increased salivation Multiple Receptors:
- increased tachycardia dopamine,
histamine,
- increased respirations serotonin,
- decreased esophageal pressure acetylcholine
- increased contraction of stomach/diaphragm
Nausea Retching Vomiting
Arcangelo et al. (2017). Gastroesophageal reflux disease. Wolters Kluwer.