1. What is the mechanism of action of paracetamol?
Answer: Inhibits prostaglandin synthesis in the CNS (analgesic & antipyretic effect).
2. Main side effect of paracetamol overdose?
Answer: Liver toxicity (hepatotoxicity).
3. Mechanism of NSAIDs?
Answer: Inhibit COX-1 and COX-2 enzymes.
4. Major side effect of NSAIDs?
Answer: Gastric ulcers and bleeding.
5. Aspirin mechanism?
Answer: Irreversibly inhibits COX enzymes.
6. Main side effect of aspirin?
Answer: Bleeding tendency.
7. Heparin mechanism?
Answer: Activates antithrombin III → inhibits clotting factors.
8. Warfarin mechanism?
Answer: Inhibits vitamin K-dependent clotting factors.
9. Warfarin antidote?
Answer: Vitamin K.
, 10. Heparin antidote?
Answer: Protamine sulfate.
11. Beta-blockers' mechanism?
Answer: Block beta-adrenergic receptors → reduce heart rate and BP.
12. Side effects of beta-blockers?
Answer: Bradycardia.
13. ACE inhibitors mechanism?
Answer: Block conversion of angiotensin I to II.
14. Side effects of ACE inhibitors?
Answer: Dry cough.
15. Calcium channel blockers mechanism?
Answer: Block calcium entry into cardiac and smooth muscle.
16. Side effects of calcium channel blockers?
Answer: Hypotension and edema.
17. Diuretics mechanism?
Answer: Increase urine output by acting on the kidneys.
18. Loop diuretics example?
Answer: Furosemide.
19. Side effects of loop diuretics?