NRNP 6675 PMHNP final EXAM A+ GRADE ASSURED COMPLETE SOLUTIONS AND VERIFIED ANSWERS

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Exam Solution
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NRNP 6566 WK1 5 Midterm 2026 A+ GRADE ASSURED
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COMPLETE SOLUTIONS AND VERIFIED ANSWERS (813 zm zm zm zm zm




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QUESTION 1 zm




Describe cytochrome p450 system
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ANSWER

Cytochrome p450 system is a series of enzymes used to metabolize medications
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QUESTION 2 zm




Inhibitors
ANSWER

block metabolic activity from one or more CYP450 enzymes
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QUESTION 3 zm




Inducers
ANSWER

increase CYP450 enzyme activity by increasing enzyme synthesis
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QUESTION 4 zm




Describe effect on low and high albumin levels on active drug levels especially for dru
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gs that are highly protein bound
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ANSWER

Albumin is the plasma protein with the greatest capacity for binding drugs. Binding plasma proteins
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affect drug distribution into tissues, because only drug that is not bound is available to penetrate ti
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, ssues, bind to receptors, and exert activity. As free drug leaves the blood stream, more bound drug i
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s released from binding sites.
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QUESTION 5 zm




Low albumin levels
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ANSWER

malnutrition, chronic illness zm zm




QUESTION 6 zm




Highly protein bound drugs can lead to
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ANSWER

toxicity in patients with low albumin levels, example malnutrition or chronic illness. This is because
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there are fewer than the normal sites for the drug to bind
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QUESTION 7 zm




Describe the ways the hepatic first pass effect-
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which is metabolism during first pass through the liver
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ANSWER

Alternative routes include: suppository intravenous intramuscular inhalational aerosol transdermal su
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blingual These allow drugs to bypass the first-
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pass effect and be absorbed directly into systemic circulation
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QUESTION 8 zm




Be able to calculate creatinine clearance using Cockgraft Gault equation:
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ANSWER

Male = 140- zm zm



age times weight in kilograms divided by serum creatinine times 72. Women = CRCL (male) times 0.
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QUESTION 9 zm




Describe what determines the frequency of drug administration
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ANSWER

half life plasma concentration
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