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This document, "NURS 611 patho exam 1 Maryville University," covers fundamental pathophysiology
concepts, including programmed cell death, acute cell injury, cellular injury due to inadequate blood
flow, ischemia, cellular structure and function, epigenetic modifications, and metabolic disturbances. The
document provides 146 questions with correct answers and detailed explanations, offering a
comprehensive review of these topics. Students can utilize this resource to study and review
pathophysiology concepts, enhancing their understanding and retention of key information for exam
preparation and clinical practice.
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EXAM QUESTIONS
QUESTION 1
A nurse is caring for a client who has been diagnosed with a condition characterized by the controlled
elimination of unwanted cells. The nurse understands that this process is primarily regulated by which
mechanism?
A) Necrosis, a form of uncontrolled cell death
B) Apoptosis, a programmed cell death mechanism
C) Mitosis, a process of cell division and growth
D) Autophagy, a process of cellular self-digestion
CORRECT ANSWER
B) Apoptosis, a programmed cell death mechanism
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, RATIONALE: The correct answer, apoptosis, is the process by which cells undergo programmed death, eliminating
unwanted cell populations. The other options are incorrect because necrosis is uncontrolled cell death, mitosis is cell
division, and autophagy is the process of cellular self-digestion, not cell death.
QUESTION 2
A client arrives at the emergency department with signs of acute cell injury. What is the primary
cellular change that leads to cell death in this condition?
A) Increased synthesis of new organelles
B) Rupture of the plasma membrane structure
C) Mitochondria dysfunction and organelle swelling
D) Decreased production of cellular enzymes
CORRECT ANSWER
C) Mitochondria dysfunction and organelle swelling
RATIONALE: In cases of acute cell injury, the primary cellular change is mitochondria dysfunction and organelle
swelling, leading to cell death. This is characterized by rapid loss of plasma membrane structure and organelle
dysfunction, ultimately resulting in necrosis. Options A and D are incorrect as cell injury is associated with decreased
synthesis of new organelles and decreased production of cellular enzymes. Option B is incorrect as the primary change
is not rupture of the plasma membrane.
QUESTION 3
The nurse is assessing a patient who is at risk for cellular injury due to inadequate blood flow to a
vital organ, leading to potential tissue damage.
A) The primary cause of cellular injury in this situation is acidosis.
B) Cellular injury is caused by an increase in metabolic pressure within the cell.
C) The #1 cause of cellular injury leading to necrosis is hypoxia.
D) Cellular injury occurs due to an increase in water pressure within the cell.
CORRECT ANSWER
C) The #1 cause of cellular injury leading to necrosis is hypoxia.
RATIONALE: Cellular injury leading to necrosis, especially in vital organs like the kidney and heart, is primarily caused
by hypoxia, or inadequate blood flow. This can result in metabolic derangements, tissue damage, and potential organ
failure. The other options are incorrect as acidosis, increased metabolic pressure, and increased water pressure are not
the primary causes of cellular injury in this scenario.
QUESTION 4
A patient has a prescription for vasopressors to manage low blood pressure due to decreased cardiac
output. What is the primary cause of this patient's decreased cardiac output?
A) Inflammation of the myocardium
B) Reduced oxygen delivery to the heart
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, C) Ischemia of the coronary arteries
D) Electrolyte imbalance
CORRECT ANSWER
C) Ischemia of the coronary arteries
RATIONALE: The primary cause of decreased cardiac output is ischemia of the coronary arteries, which reduces the
heart's ability to pump blood effectively. This leads to decreased cardiac output and subsequent hypoxia. Inflammation
of the myocardium (A) can cause decreased cardiac function, but it is not the primary cause. Reduced oxygen delivery
to the heart (B) can also contribute to decreased cardiac output, but it is not the primary cause. Electrolyte imbalance
(D) is not directly related to decreased cardiac output in this scenario.
QUESTION 5
The nurse receives report on four clients: Sarah with kidney disease, Michael with anemia, Rachel
with leukemia, and Emily with a benign tumor. Which component of a cell is mainly responsible for
storing genetic information?
A) Mitochondria
B) Nucleus
C) Cytoplasm
D) Cell membrane
CORRECT ANSWER
B) Nucleus
RATIONALE: The cell nucleus contains genetic material, including DNA, which stores and transmits genetic information.
While the other options are cellular components, they do not play a primary role in storing genetic information.
Mitochondria generate energy for the cell, cytoplasm is a gel-like substance surrounding cell organelles, and the cell
membrane is the outer layer of the cell.
QUESTION 6
A client reports being puzzled about the structure of cells. The client asks the nurse, "What is found in
the nucleus that's responsible for protein synthesis?"
A) Ribosomes
B) Mitochondria
C) Nucleolus
D) Lysosomes
CORRECT ANSWER
C) Nucleolus
RATIONALE: The correct answer is the nucleolus, as it is responsible for protein synthesis within the nucleus. The
nucleolus produces ribosomal RNA and assembles ribosomes, which are essential for protein synthesis. Ribosomes,
option A, are found in the cytoplasm, not the nucleus. Mitochondria, option B, are the powerhouses of the cell but are
not involved in protein synthesis. Lysosomes, option D, are membrane-bound organelles that contain digestive enzymes.
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, QUESTION 7
A nurse observes a microscopic structure within a cell that is responsible for producing ribosomal RNA
and contains most of the cell's cellular DNA.
A) Mitochondria
B) Nucleolus
C) Lysosome
D) Cytoskeleton
CORRECT ANSWER
B) Nucleolus
RATIONALE: The nucleolus is a specialized region within the nucleus that produces ribosomal RNA and contains most of
the cell's cellular DNA. It is responsible for synthesizing ribosomal subunits, which are essential for protein synthesis.
The other options are incorrect because the mitochondria is the site of cellular respiration, the lysosome is a membrane-
bound organelle responsible for breaking down waste, and the cytoskeleton is a network of protein filaments that
provides structural support to the cell.
QUESTION 8
After reviewing the client's chart, the nurse recognizes the significance of histone's role in the cell
division process. Which of the following is the primary function of histones?
A) Protect the DNA from damage
B) Facilitate transcription and replication of genetic material
C) Regulate gene expression through epigenetic modifications
D) Maintain chromosome structure and organization during cell division
CORRECT ANSWER
D) Maintain chromosome structure and organization during cell division
RATIONALE: Histones bind to DNA and fold it into chromosomes (chromatin), which is essential for cell division. This
process allows for the proper organization and maintenance of chromosome structure, enabling the accurate division of
cells during mitosis and meiosis. Options A and C are related but incorrect, as histones do not primarily protect DNA
from damage or regulate gene expression. Option B is also incorrect, as transcription and replication are facilitated by
other proteins and processes.
QUESTION 9
The healthcare provider prescribes medication for a patient with a rare condition requiring the
synthesis of proteins. The patient asks the nurse what is being produced to help alleviate their
symptoms.
A) Lysosomes
B) Mitochondria
C) RNA-protein complexes (nucleoproteins)
D) Golgi apparatus
CORRECT ANSWER
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