Exam Questions 1- 100 NR-565 Advanced Pharmacology Fundamentals
NR 565 Midterm and Finals Examplify Online Proctored Exam
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, Week 1 – Foundations in Pharmacology
1. A patient's nutritional intake and laboratory results reflect
hypoalbuminemia. This is critical to prescribing because:
• A) Absorption of drugs from the GI tract will be decreased
• B) Distribution of drugs to target tissue may be affected
• C) Drug metabolism by the liver will be increased
• D) Renal excretion of drugs will be accelerated
✔ Correct Answer: B) Distribution of drugs to target tissue may be
affected
• Rationale: Hypoalbuminemia (low serum albumin) means fewer
protein-binding sites are available for highly protein-bound drugs.
This leads to a higher proportion of unbound ("free") drug, which
increases distribution to target tissues and the risk of toxicity.
2. Drugs that have a significant first-pass effect:
• A) Are rapidly metabolized by the liver and may have little if any
desired action
• B) Are primarily excreted unchanged by the kidneys
• C) Must be administered intravenously to be effective
• D) Have a prolonged duration of action
✔ Correct Answer: A) Are rapidly metabolized by the liver and may
have little if any desired action
• Rationale: First-pass effect occurs when orally administered drugs
are metabolized in the liver before reaching systemic circulation.