NR546 Final 84 QUESTIONS AND 100% CORRECT
SOLUTIONS|UPDATED VERSION 2026/2027]!!!|GUARANTEED
PASS|EXAM READY
1. MAOIs (monoamine oxidase inhibitors) affect which neurotransmitters?
A. Serotonin, Dopamine, Norepinephrine
B. Serotonin, GABA, Glutamate
C. Acetylcholine, Dopamine, Norepinephrine
D. Dopamine, GABA, Acetylcholine
Correct Answer: A
Rationale: MAOIs inhibit monoamine oxidase, increasing levels of serotonin, dopamine, and
norepinephrine in the brain.
2. Which of the following is considered first-line treatment for depression?
A. SSRI
B. FGA
C. SNRI
D. MAOI
Correct Answer: A
Rationale: SSRIs are first-line due to efficacy, safety profile, and tolerability.
3. When treating a patient for major depressive disorder, which medication would the PMHNP
consider first?
A. Depakote
B. Selegiline
C. Escitalopram
D. Isocarboxazid
Correct Answer: C
Rationale: Escitalopram is an SSRI and first-line for MDD.
4. Which medication should be considered for a patient who reports “always forgetting to take my
pills”?
A. Mirtazapine
B. Fluvoxamine
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,C. Fluoxetine
D. Carbamazepine
Correct Answer: C
Rationale: Fluoxetine has a long half-life, making missed doses less impactful.
5. Which medication has a black box warning for life-threatening skin rash?
A. Lithium
B. Lamotrigine
C. Lurasidone
D. Lorazepam
Correct Answer: B
Rationale: Lamotrigine is associated with Stevens-Johnson syndrome.
6. Which SSRI is considered best tolerated?
A. Venlafaxine
B. Bupropion
C. Sertraline
D. Escitalopram
Correct Answer: D
Rationale: Escitalopram has the best tolerability and fewest side effects.
7. A patient on sertraline 25 mg shows mild improvement at 4 weeks. What should the PMHNP do?
A. Increase sertraline dose
B. Switch to SNRI
C. Switch SSRI
D. Add trazodone
Correct Answer: A
Rationale: SSRIs are titrated upward if partial response occurs.
8. Which medication should be avoided in a 66-year-old with depression and history of falls?
A. Citalopram
B. Sertraline
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, C. Paroxetine
D. Aripiprazole
Correct Answer: C
Rationale: Paroxetine is highly anticholinergic and increases fall risk.
9. Patient with GI upset 3 days after sertraline initiation—best response?
A. Double dose
B. Side effects usually resolve in 4–5 days
C. Stop medication
D. Must take with food
Correct Answer: B
Rationale: Early SSRI GI side effects are common and transient.
10. Escitalopram shows no effect at 2 weeks. Correct statement?
A. Stop medication
B. Takes up to 6 weeks
C. Switch immediately
D. Double dose
Correct Answer: B
Rationale: Full SSRI response takes 4–6 weeks.
11. Duloxetine affects which neurotransmitters?
A. Serotonin and norepinephrine
B. Serotonin and dopamine
C. GABA and norepinephrine
D. Glutamate and acetylcholine
Correct Answer: A
Rationale: SNRI increases serotonin and norepinephrine.
12. Depression patient with weight loss—best medication?
A. Quetiapine
B. Mirtazapine
3|Page
SOLUTIONS|UPDATED VERSION 2026/2027]!!!|GUARANTEED
PASS|EXAM READY
1. MAOIs (monoamine oxidase inhibitors) affect which neurotransmitters?
A. Serotonin, Dopamine, Norepinephrine
B. Serotonin, GABA, Glutamate
C. Acetylcholine, Dopamine, Norepinephrine
D. Dopamine, GABA, Acetylcholine
Correct Answer: A
Rationale: MAOIs inhibit monoamine oxidase, increasing levels of serotonin, dopamine, and
norepinephrine in the brain.
2. Which of the following is considered first-line treatment for depression?
A. SSRI
B. FGA
C. SNRI
D. MAOI
Correct Answer: A
Rationale: SSRIs are first-line due to efficacy, safety profile, and tolerability.
3. When treating a patient for major depressive disorder, which medication would the PMHNP
consider first?
A. Depakote
B. Selegiline
C. Escitalopram
D. Isocarboxazid
Correct Answer: C
Rationale: Escitalopram is an SSRI and first-line for MDD.
4. Which medication should be considered for a patient who reports “always forgetting to take my
pills”?
A. Mirtazapine
B. Fluvoxamine
1|Page
,C. Fluoxetine
D. Carbamazepine
Correct Answer: C
Rationale: Fluoxetine has a long half-life, making missed doses less impactful.
5. Which medication has a black box warning for life-threatening skin rash?
A. Lithium
B. Lamotrigine
C. Lurasidone
D. Lorazepam
Correct Answer: B
Rationale: Lamotrigine is associated with Stevens-Johnson syndrome.
6. Which SSRI is considered best tolerated?
A. Venlafaxine
B. Bupropion
C. Sertraline
D. Escitalopram
Correct Answer: D
Rationale: Escitalopram has the best tolerability and fewest side effects.
7. A patient on sertraline 25 mg shows mild improvement at 4 weeks. What should the PMHNP do?
A. Increase sertraline dose
B. Switch to SNRI
C. Switch SSRI
D. Add trazodone
Correct Answer: A
Rationale: SSRIs are titrated upward if partial response occurs.
8. Which medication should be avoided in a 66-year-old with depression and history of falls?
A. Citalopram
B. Sertraline
2|Page
, C. Paroxetine
D. Aripiprazole
Correct Answer: C
Rationale: Paroxetine is highly anticholinergic and increases fall risk.
9. Patient with GI upset 3 days after sertraline initiation—best response?
A. Double dose
B. Side effects usually resolve in 4–5 days
C. Stop medication
D. Must take with food
Correct Answer: B
Rationale: Early SSRI GI side effects are common and transient.
10. Escitalopram shows no effect at 2 weeks. Correct statement?
A. Stop medication
B. Takes up to 6 weeks
C. Switch immediately
D. Double dose
Correct Answer: B
Rationale: Full SSRI response takes 4–6 weeks.
11. Duloxetine affects which neurotransmitters?
A. Serotonin and norepinephrine
B. Serotonin and dopamine
C. GABA and norepinephrine
D. Glutamate and acetylcholine
Correct Answer: A
Rationale: SNRI increases serotonin and norepinephrine.
12. Depression patient with weight loss—best medication?
A. Quetiapine
B. Mirtazapine
3|Page
