, NU 636 QUIZ 1 | QUESTIONS AND
ANSWERS | 2026 UPDATE | 100%
CORRECT.
SECTION 1: ADVERSE DRUG REACTIONS &
PHARMACOGENETICS (Questions 1-10)
Q1. A type B adverse drug reaction (ADR) is one that is unrelated to
the pharmacologic action of the drug. They are precipitated by
secondary pharmacologic actions of the drug, may be unpredictable,
and may or may not be dose dependent. ADRs observed by
practitioners should be reported to the FDA through which
program?
A. Vaccine Injury Program
B. NIH Clinical Trial Monitoring Program
C. MedWatch Program
D. Patient Injury Program
Correct Answer: C. MedWatch Program
Rationale: The FDA's MedWatch program is the voluntary reporting system
for healthcare professionals to report serious adverse events, product quality
problems, and medication errors. Type B ADRs are idiosyncratic and
unpredictable reactions not related to the drug's primary pharmacology .
, Q2. Your patient has undergone genetic testing and found to have a
CYP2D6 polymorphism poor-metabolism phenotype. You know that
the tricyclic anti-depressant medications are metabolized by the
CYP2D6 enzyme pathway. You plan on prescribing amitriptyline for
your patient for their depression. A starting dose of amitriptyline is
50-100 mg daily at bedtime. Given the patient's poor metabolizer
phenotype, which of the following doses of amitriptyline would be
the appropriate dose for the patient to be started on?
A. 25 mg
B. 500 mg
C. 100 mg
D. 200 mg
Correct Answer: A. 25 mg
Rationale: CYP2D6 is the primary enzyme responsible for metabolizing
tricyclic antidepressants, including amitriptyline. Poor metabolizers (PMs)
have significantly reduced enzyme activity, leading to higher drug
concentrations and increased risk of toxicity at standard doses. Therefore,
PMs should be started at lower doses (approximately 50% of standard
starting dose) and titrated slowly with therapeutic drug monitoring .
Q3. Studies show this herb stimulates phagocytosis while increasing
respiratory cellular activity and mobility of leukocytes. Uses include
treatment of skin conditions and the common cold. The herb is
which of the following?
A. Echinacea
B. Uva Ursi
ANSWERS | 2026 UPDATE | 100%
CORRECT.
SECTION 1: ADVERSE DRUG REACTIONS &
PHARMACOGENETICS (Questions 1-10)
Q1. A type B adverse drug reaction (ADR) is one that is unrelated to
the pharmacologic action of the drug. They are precipitated by
secondary pharmacologic actions of the drug, may be unpredictable,
and may or may not be dose dependent. ADRs observed by
practitioners should be reported to the FDA through which
program?
A. Vaccine Injury Program
B. NIH Clinical Trial Monitoring Program
C. MedWatch Program
D. Patient Injury Program
Correct Answer: C. MedWatch Program
Rationale: The FDA's MedWatch program is the voluntary reporting system
for healthcare professionals to report serious adverse events, product quality
problems, and medication errors. Type B ADRs are idiosyncratic and
unpredictable reactions not related to the drug's primary pharmacology .
, Q2. Your patient has undergone genetic testing and found to have a
CYP2D6 polymorphism poor-metabolism phenotype. You know that
the tricyclic anti-depressant medications are metabolized by the
CYP2D6 enzyme pathway. You plan on prescribing amitriptyline for
your patient for their depression. A starting dose of amitriptyline is
50-100 mg daily at bedtime. Given the patient's poor metabolizer
phenotype, which of the following doses of amitriptyline would be
the appropriate dose for the patient to be started on?
A. 25 mg
B. 500 mg
C. 100 mg
D. 200 mg
Correct Answer: A. 25 mg
Rationale: CYP2D6 is the primary enzyme responsible for metabolizing
tricyclic antidepressants, including amitriptyline. Poor metabolizers (PMs)
have significantly reduced enzyme activity, leading to higher drug
concentrations and increased risk of toxicity at standard doses. Therefore,
PMs should be started at lower doses (approximately 50% of standard
starting dose) and titrated slowly with therapeutic drug monitoring .
Q3. Studies show this herb stimulates phagocytosis while increasing
respiratory cellular activity and mobility of leukocytes. Uses include
treatment of skin conditions and the common cold. The herb is
which of the following?
A. Echinacea
B. Uva Ursi
