1|Page
NUR 600 Advanced Nursing Practice & Theory
Examination 1, 2026/2027-Question Evidence-Based
Advanced Nursing Competency Assessment||Newest
Exam!!!
Drugs that have a significant first-pass effect: A. Must be
given by the enteral (oral) route only
B. Bypass the hepatic circulation
C. Are rapidly metabolized by the liver and may have little
if any desired action
D. Are converted by the liver to more active and fat-soluble
forms - Answer-C. Are rapidly metabolized by the liver and
may have little if any desired action
The route of excretion of a volatile drug will likely be:
A. The kidneys
B. The lungs
C. The bile and feces
D. The skin - Answer-B. The lungs
Medroxyprogesterone (Depo Provera) is prescribed IM to
create a storage reservoir of the drug. Storage reservoirs:
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A. Assure that the drug will reach its intended target tissue
B. Are the reason for giving loading doses
C. Increase the length of time a drug is available and
active
D. Are most common in collagen tissues - Answer-C.
Increase the length of time a drug is available and active
The NP chooses to give cephalexin every 8 hours based
on knowledge of the drug's:
A. Propensity to go to the target receptor
B. Biological half-life
C. Pharmacodynamics
D. Safety and side effects - Answer-B. Biological half-life
Azithromycin dosing requires the first day's dose be twice
those of the other 4 days of the prescription. This is
considered a loading dose. A loading dose: A. Rapidly
achieves drug levels in the therapeutic range
B. Requires four to five half-lives to attain
C. Is influenced by renal function
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D. Is directly related to the drug circulating to the target
tissues - Answer-A. Rapidly achieves drug levels in the
therapeutic range
The point in time on the drug concentration curve that
indicates the first sign of a therapeutic effect is the:
A. Minimum adverse effect level
B. Peak of action
C. Onset of action
D. Therapeutic range - Answer-C. Onset of action
Phenytoin requires a trough level be drawn. Peak and
trough levels are done: A. When the drug has a wide
therapeutic range
B. When the drug will be administered for a short time only
C. When there is a high correlation between the dose and
saturation of receptor sites
D. To determine if a drug is in the therapeutic range -
Answer-D. To determine if a drug is in the therapeutic
range
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A laboratory result indicates the peak level for a drug is
above the minimum toxic concentration. This means that
the:
A. Concentration will produce therapeutic effects
B. Concentration will produce an adverse response
C. Time between doses must be shortened
D. Duration of action of the drug is too long - Answer-B.
Concentration will produce an adverse response
Drugs that are receptor agonists may demonstrate what
property?
A. Irreversible binding to the drug receptor site
B. Up-regulation with chronic use
C. Desensitization or down-regulation with continuous use
D. Inverse relationship between drug concentration and
drug action - Answer-C. Desensitization or down-
regulation with continuous use
Drugs that are receptor antagonists, such as beta
blockers, may cause:
A. Down-regulation of the drug receptor
B. An exaggerated response if abruptly discontinued
NUR 600 Advanced Nursing Practice & Theory
Examination 1, 2026/2027-Question Evidence-Based
Advanced Nursing Competency Assessment||Newest
Exam!!!
Drugs that have a significant first-pass effect: A. Must be
given by the enteral (oral) route only
B. Bypass the hepatic circulation
C. Are rapidly metabolized by the liver and may have little
if any desired action
D. Are converted by the liver to more active and fat-soluble
forms - Answer-C. Are rapidly metabolized by the liver and
may have little if any desired action
The route of excretion of a volatile drug will likely be:
A. The kidneys
B. The lungs
C. The bile and feces
D. The skin - Answer-B. The lungs
Medroxyprogesterone (Depo Provera) is prescribed IM to
create a storage reservoir of the drug. Storage reservoirs:
,2|Page
A. Assure that the drug will reach its intended target tissue
B. Are the reason for giving loading doses
C. Increase the length of time a drug is available and
active
D. Are most common in collagen tissues - Answer-C.
Increase the length of time a drug is available and active
The NP chooses to give cephalexin every 8 hours based
on knowledge of the drug's:
A. Propensity to go to the target receptor
B. Biological half-life
C. Pharmacodynamics
D. Safety and side effects - Answer-B. Biological half-life
Azithromycin dosing requires the first day's dose be twice
those of the other 4 days of the prescription. This is
considered a loading dose. A loading dose: A. Rapidly
achieves drug levels in the therapeutic range
B. Requires four to five half-lives to attain
C. Is influenced by renal function
,3|Page
D. Is directly related to the drug circulating to the target
tissues - Answer-A. Rapidly achieves drug levels in the
therapeutic range
The point in time on the drug concentration curve that
indicates the first sign of a therapeutic effect is the:
A. Minimum adverse effect level
B. Peak of action
C. Onset of action
D. Therapeutic range - Answer-C. Onset of action
Phenytoin requires a trough level be drawn. Peak and
trough levels are done: A. When the drug has a wide
therapeutic range
B. When the drug will be administered for a short time only
C. When there is a high correlation between the dose and
saturation of receptor sites
D. To determine if a drug is in the therapeutic range -
Answer-D. To determine if a drug is in the therapeutic
range
, 4|Page
A laboratory result indicates the peak level for a drug is
above the minimum toxic concentration. This means that
the:
A. Concentration will produce therapeutic effects
B. Concentration will produce an adverse response
C. Time between doses must be shortened
D. Duration of action of the drug is too long - Answer-B.
Concentration will produce an adverse response
Drugs that are receptor agonists may demonstrate what
property?
A. Irreversible binding to the drug receptor site
B. Up-regulation with chronic use
C. Desensitization or down-regulation with continuous use
D. Inverse relationship between drug concentration and
drug action - Answer-C. Desensitization or down-
regulation with continuous use
Drugs that are receptor antagonists, such as beta
blockers, may cause:
A. Down-regulation of the drug receptor
B. An exaggerated response if abruptly discontinued
