HEMATOLOGY USMLE STEP 1 QUESTIONS WITH CORRECT ANSWERS

Aggregation is mediated by ______ resulting in _____ blood flow.


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TXA2
decreased




HbA2


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Adult Hb = 2 alpha, 2 delta chains

- <3% of total adult Hb
- Glycosylation is marker for chronically high blood sugar

,Anemia of Chronic Disease is associated w/ what conditions?


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RA
SLE
Cancer/Neoplasia
Chronic Kidney Disease




Etiology of Microcytic, Hypochromic Anemia


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(A-LIST)

Anemia of Chronic Disease (late in disease)
Lead Poisoning
Iron Deficiency Anemia (late in disease)
Sideroblastic Anemia
Thalassemia




Abnormal platelet activation leads to ...


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, Arterial Occlusion

- Coronary arteries = MI
- CNS = stroke
- Peripheral arteries = gangrenous limbs




Alpha Thalassemia: 4 gene deletion
a. Pathophysiology
b. S/S
c. Electrophoresis


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Hydrops Fetalis
a. (--/--)
- No alpha globin formed
- Gamma chains aggregate forming tetramers and damaging RBCs in utero


b. Incompatible w/ life
c. Hb Barts (gamma 4 tetramers)




Target Cells associated w/:


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(HALT)

HbC disease
Asplenia
Liver Disease
Thalassemia

, Hereditary Disorders leading to Hypercoagulability


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- Anti-Thrombin 3 Deficiency
- Factor 5 Leiden
- Protein C or S Deficiency
- Prothrombin Gene mutation
- Anti-phospholipid Syndrome




Hemophilia B


a. Inheritance
b. Etiology
c. Tx


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a. X-linked
- Females can experience lyonization and cause low levels of factor 8

b. Factor 9 deficiency

c. Desmopressin + Factor 9




What is Glanzmann thrombasthenia?


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