Neutrophils, macrophages, monocytes, dendritic cells, natural killer (NK) cells
(lymphoid origin), complement
Germline encoded
Nonspecific
Occurs rapidly (minutes to hours)
Epithelial tight junctions, mucus
Lysozyme, complement, C-reactive protein (CRP), defensins
Give this one a try later!
, Innate immunity:
- components
- mechanism
- response to pathogens
- physical barriers
- secreted proteins
Hot T-Bone stEAK
IL1 - fever (hot)
IL2 - stimulates T cells
IL3 - stimulates Bone marrow
IL4 - stimulates IgE production. Induces differentiation into Th2 cells. Promotes
growth of B cells. Enhances class switching to IgE and IgG.
IL5 - stimulates IgA production. Promotes differentiation of B cells. Enhances class
switching to IgA. Stimulates growth and differentiation of eosinophils.
IL6 - stimulates aKute-phase protein
production.
IL12 - stimulates differentiation of T cells into TH1 cells. Activates NK cells.
TNF-a - Mediates septic shock. Activates endothelium. Causes WBC recruitment,
vascular leak.
Interferon-y - Mediates septic shock. Activates endothelium. Causes WBC
recruitment, vascular leak. Also activates NK cells to kill virus-infected cells. Increases
MHC expression and antigen presentation by all cells.
IL-10 - Modulates inflammatory response. Decreases expression of MHC class II and
Th1 cytokines.
(lymphoid origin), complement
Germline encoded
Nonspecific
Occurs rapidly (minutes to hours)
Epithelial tight junctions, mucus
Lysozyme, complement, C-reactive protein (CRP), defensins
Give this one a try later!
, Innate immunity:
- components
- mechanism
- response to pathogens
- physical barriers
- secreted proteins
Hot T-Bone stEAK
IL1 - fever (hot)
IL2 - stimulates T cells
IL3 - stimulates Bone marrow
IL4 - stimulates IgE production. Induces differentiation into Th2 cells. Promotes
growth of B cells. Enhances class switching to IgE and IgG.
IL5 - stimulates IgA production. Promotes differentiation of B cells. Enhances class
switching to IgA. Stimulates growth and differentiation of eosinophils.
IL6 - stimulates aKute-phase protein
production.
IL12 - stimulates differentiation of T cells into TH1 cells. Activates NK cells.
TNF-a - Mediates septic shock. Activates endothelium. Causes WBC recruitment,
vascular leak.
Interferon-y - Mediates septic shock. Activates endothelium. Causes WBC
recruitment, vascular leak. Also activates NK cells to kill virus-infected cells. Increases
MHC expression and antigen presentation by all cells.
IL-10 - Modulates inflammatory response. Decreases expression of MHC class II and
Th1 cytokines.
