Importance of phosphorylated intermediates (3)
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1. Because the plasma membrane lacks transporters for phosphorylated
sugars, the phosphorylated glycolytic intermediates cannot leave cell.
After initial phosphorylation, no further energy is necessary to retain
phosphorylated intermediates in the cell.
2. Phosphoryl groups are enzymatic conservation of metabolic energy.
These phosphate compounds donate phosphoryl groups to ADP to form
ATP.
, 3. Binding energy lowers the activation energy and increases the
specificity of the enzymatic reactions
Most glycolytic enzymes require Mg2+ for activity.
Glycolysis
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Near-universal pathway in which glucose molecule is oxidized to two
molecules of pyruvate, with energy conserved as ATP and NADH
Isozymes
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Catalyze same reaction but encoded by different genes
Glycolysis: Payoff phase
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1. Because the plasma membrane lacks transporters for phosphorylated
sugars, the phosphorylated glycolytic intermediates cannot leave cell.
After initial phosphorylation, no further energy is necessary to retain
phosphorylated intermediates in the cell.
2. Phosphoryl groups are enzymatic conservation of metabolic energy.
These phosphate compounds donate phosphoryl groups to ADP to form
ATP.
, 3. Binding energy lowers the activation energy and increases the
specificity of the enzymatic reactions
Most glycolytic enzymes require Mg2+ for activity.
Glycolysis
Give this one a try later!
Near-universal pathway in which glucose molecule is oxidized to two
molecules of pyruvate, with energy conserved as ATP and NADH
Isozymes
Give this one a try later!
Catalyze same reaction but encoded by different genes
Glycolysis: Payoff phase
Give this one a try later!
