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Applied Pathophysiology Exam Questions Comprehensive
2026 Questions Exam Latest Version Solved Questions &
Answers Verified 100 %
Mr. Forbes complains of "indigestion" and becomes sweaty and pale. His wife
takes him to the Emergency Department at Northwestern Memorial Hospital. A
cardiac catheterization 2 days later shows partial blockage of his right
coronary artery (RCA).
Blockage of the right coronary artery can lead to myocardial cell injury
because it results in which of the following?
a. bilirubin accumulation in myocardial cells
b. alteration in the genetic material of myocardial cells
c. reduced energy production in myocardial cells
d. activation of the complement system
C
When myocardial cells are injured, the function of the Na-K membrane pump
may be impaired. Which of the following may then result?
a.intracellular sodium will increase
b. extracellular potassium will decrease
c. cell volume will decrease
d. all of the above
A
Mr. Forbes is being prepared for open heart surgery when he suffers a
myocardial infarction in which a large part of his left ventricle has suffered
lethal cell injury.
Mr. Forbes' CPK-MB and LDH1, enzymes associated with myocardial cells, are
significantly elevated. What is the best explanation for this?
a. It is a sign that necrotic myocardial cells have released their cytoplasmic
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contents into the blood.
b. It is a sign of reversible fatty accumulation in the myocardial cells
c. It is a sign that the myocardial cells are undergoing hypertrophy.
d. None of the above.
A
If a tissue specimen of myocardial cells were obtained for examination from
Mr. Forbes, which of the following findings would indicate irreversible cell
injury?
a. cellular swelling
b. decreased ATP production
c. decreased intracellular calcium
d. dissolution of nuclear material
D
The accumulation of lactic acid that occurs with impaired energy production
results from which of the following?
a. increased intracellular glucose
b. increased anaerobic metabolism
c. decreased metabolic rate
d. increased oxidative phosphorylation
B
A mountain climber is stranded at 23,000 feet in the Swiss Alps and has lost all
his equipment and supplies in an avalanche. Subsequently, he suffers cell
injury due to impaired ATP production. The reason for the decrease in ATP is
which of the following?
a. enzyme inhibition
b. uncoupling
c. hypoxia
d. none of the above
C
An elderly patient develops an obstruction in his left middle cerebral artery.
The brain tissue supplied by this artery becomes hypoxic. The best
explanation for this is which of the following?
a. the obstruction results in decreased blood flow
b. the obstruction results in decreased hemoglobin in the blood
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c. while blood flow stays the same, the obstruction reduces oxygen content in
the blood
d. none of the above explain the reason for the hypoxia
A
Increased mobilization and delivery of free fatty acids to liver cells can result
in fat accumulation. Which of the following problems results in increased
mobilization of free fatty acids?
a. anemia
b. hepatic toxins
c. starvation
d. hypoxia
C
Generalized hypoxia results in a switch to anaerobic metabolism in cells.
Anaerobic metabolism results in which of the following?
a. decreased lactic acid inside cells
b. decreased arterial pH
c. more effective ATP production
d. increased pH inside cells
B
There is a disease of the spleen, which results in an excessive destruction of
RBCs. This increase in RBC destruction can lead to which of the following?
a. hypoxia
b. hypobilirubinemia
c. an increase in platelets
d. all of the above
A
Your body has developed an increased demand for thyroid hormones. This will
lead to ____________ of the thyroid gland.
a. atrophy
b. hypertrophy
c. dysplasia
d. metaplasia
B
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You palpate a gangrenous leg and note the presence of crepitus. Crepitus is
associated with which of the following?
a. wet gangrene
b. dry gangrene
c. gas gangrene
d. all of the above
C
Direct cell membrane destruction may result from which of the following?
a. complement activation
b. bacterial enzymes
c. free radicals
d. all of the above
D
Which of the following is true regarding apoptosis?
a. It occurrence may be physiological or pathological.
b. It does not stimulate the inflammatory process.
c. It results in phagocytosis of the apoptotic cell.
d. all of the above.
D
A certain disease is currently found in 1 of every 10 people in the country and
1,000 people contract the disease yearly. The population of the country is
4,500,000. Which of the following statements is correct?
a. The prevalence of the disease is 10% and the incidence is .02%.
b. The prevalence of the disease is .02% and the incidence is 10%.
c. Neither is correct.
d. There is insufficient data
A
In relation to disease development, the term "etiology" refers to which of the
following?
a.number of people with the disease
b. cause of the disease
c. definition of the disease
d. outcome of the disease
Applied Pathophysiology Exam Questions Comprehensive
2026 Questions Exam Latest Version Solved Questions &
Answers Verified 100 %
Mr. Forbes complains of "indigestion" and becomes sweaty and pale. His wife
takes him to the Emergency Department at Northwestern Memorial Hospital. A
cardiac catheterization 2 days later shows partial blockage of his right
coronary artery (RCA).
Blockage of the right coronary artery can lead to myocardial cell injury
because it results in which of the following?
a. bilirubin accumulation in myocardial cells
b. alteration in the genetic material of myocardial cells
c. reduced energy production in myocardial cells
d. activation of the complement system
C
When myocardial cells are injured, the function of the Na-K membrane pump
may be impaired. Which of the following may then result?
a.intracellular sodium will increase
b. extracellular potassium will decrease
c. cell volume will decrease
d. all of the above
A
Mr. Forbes is being prepared for open heart surgery when he suffers a
myocardial infarction in which a large part of his left ventricle has suffered
lethal cell injury.
Mr. Forbes' CPK-MB and LDH1, enzymes associated with myocardial cells, are
significantly elevated. What is the best explanation for this?
a. It is a sign that necrotic myocardial cells have released their cytoplasmic
, Page 2 of 38
contents into the blood.
b. It is a sign of reversible fatty accumulation in the myocardial cells
c. It is a sign that the myocardial cells are undergoing hypertrophy.
d. None of the above.
A
If a tissue specimen of myocardial cells were obtained for examination from
Mr. Forbes, which of the following findings would indicate irreversible cell
injury?
a. cellular swelling
b. decreased ATP production
c. decreased intracellular calcium
d. dissolution of nuclear material
D
The accumulation of lactic acid that occurs with impaired energy production
results from which of the following?
a. increased intracellular glucose
b. increased anaerobic metabolism
c. decreased metabolic rate
d. increased oxidative phosphorylation
B
A mountain climber is stranded at 23,000 feet in the Swiss Alps and has lost all
his equipment and supplies in an avalanche. Subsequently, he suffers cell
injury due to impaired ATP production. The reason for the decrease in ATP is
which of the following?
a. enzyme inhibition
b. uncoupling
c. hypoxia
d. none of the above
C
An elderly patient develops an obstruction in his left middle cerebral artery.
The brain tissue supplied by this artery becomes hypoxic. The best
explanation for this is which of the following?
a. the obstruction results in decreased blood flow
b. the obstruction results in decreased hemoglobin in the blood
, Page 3 of 38
c. while blood flow stays the same, the obstruction reduces oxygen content in
the blood
d. none of the above explain the reason for the hypoxia
A
Increased mobilization and delivery of free fatty acids to liver cells can result
in fat accumulation. Which of the following problems results in increased
mobilization of free fatty acids?
a. anemia
b. hepatic toxins
c. starvation
d. hypoxia
C
Generalized hypoxia results in a switch to anaerobic metabolism in cells.
Anaerobic metabolism results in which of the following?
a. decreased lactic acid inside cells
b. decreased arterial pH
c. more effective ATP production
d. increased pH inside cells
B
There is a disease of the spleen, which results in an excessive destruction of
RBCs. This increase in RBC destruction can lead to which of the following?
a. hypoxia
b. hypobilirubinemia
c. an increase in platelets
d. all of the above
A
Your body has developed an increased demand for thyroid hormones. This will
lead to ____________ of the thyroid gland.
a. atrophy
b. hypertrophy
c. dysplasia
d. metaplasia
B
, Page 4 of 38
You palpate a gangrenous leg and note the presence of crepitus. Crepitus is
associated with which of the following?
a. wet gangrene
b. dry gangrene
c. gas gangrene
d. all of the above
C
Direct cell membrane destruction may result from which of the following?
a. complement activation
b. bacterial enzymes
c. free radicals
d. all of the above
D
Which of the following is true regarding apoptosis?
a. It occurrence may be physiological or pathological.
b. It does not stimulate the inflammatory process.
c. It results in phagocytosis of the apoptotic cell.
d. all of the above.
D
A certain disease is currently found in 1 of every 10 people in the country and
1,000 people contract the disease yearly. The population of the country is
4,500,000. Which of the following statements is correct?
a. The prevalence of the disease is 10% and the incidence is .02%.
b. The prevalence of the disease is .02% and the incidence is 10%.
c. Neither is correct.
d. There is insufficient data
A
In relation to disease development, the term "etiology" refers to which of the
following?
a.number of people with the disease
b. cause of the disease
c. definition of the disease
d. outcome of the disease
