preparation material
which of the following receptors signals through coupling to a Gq - correct answer ✔✔- alpha 1
- 5-HT2
which of the following is true regarding the 5-HT pathways - correct answer ✔✔- slow wave
sleep regulation is mediated by the 5-HT2 receptor
which of the following is true for depression - correct answer ✔✔- when treatment of
depression results in greater than 50% improvement in symptoms, the patient is called to be in
response
which of the following is true for MAO - correct answer ✔✔- MAO inhibitors was originally
discovered because of antidepressive "side effect" in patients treated for tuberculosis
- increased MAO-A activity was suggested to be linked to some types of treatment-resistant
depression
which of the following is true for tricyclic antidepressants - correct answer ✔✔- tricyclic
antidepressants cause weight gain due to blockade of H1 histamine receptor
- tricyclic antidepressants was originally discovered because of the anti depressive "side effect"
in patients treated for schizophrenia
which of the following is true for alpha 1 subtype adrenergic receptors - correct answer ✔✔-
located in the sympathetic system where it controls urinary retention
which of the following is true for NE-serotonin interaction - correct answer ✔✔- terminal
adrenergic heteroreceptors inhibit adenyl cyclase activity and cause decrease in serotonin
release
, - the NE system in the brainstem acts to accelerate serotonin release
the sedating effect of tricyclic antidepressants is because of their blockade of which of the
following receptors - correct answer ✔✔- histamine receptor
- cholinergic receptor
which of these SSRIs is/are more activating, energizing, and thus preferred for fatigue reducing
symptoms - correct answer ✔✔- fluoxetine
which of the following is not a symptom of NE deficiency syndrome - correct answer ✔✔-
obsession and compulsion
which of the following is true for monoamine hypothesis - correct answer ✔✔- depression is
caused by deficiency of monoamines
which of the following is true for the monoamine receptor hypothesis - correct answer ✔✔- the
mechanism of therapeutic action of the SSRI is down regulation of the somatodendritic 5-HT1A
autorecpetors
- the monoamine receptor hypothesis is supported by the fact the elevation of serotonin levels
by SSRI first observed in the raphe nucleus and later on in the cortex
increase monoamine levels in the raphe nucleus results in - correct answer ✔✔- desensitization
of the 5HT1A receptors
- down regulation of the 5HT1A receptors
which of the following drug mechanism include 5HT1A partial agonism - correct answer ✔✔-
SPARI
which of the following drugs block monoamine reuptake - correct answer ✔✔- SPARI