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agonist - ANSWER ✔✔-like that of an endogenous substance
-the drug can produce a greater effect than the endogenous substance
antagonist - ANSWER ✔✔prevents the endogenous substance from:
-acting due to receptor competition
-inhibiting the effect of an agonist by changing the pharmacokinetic
processes of the agonist
,partial agonist - ANSWER ✔✔produces a weaker, or less efficacious,
response compared to an agonist
therapeutic index - ANSWER ✔✔the ratio between the toxic &
therapeutic concentrations of a drug
pharmacodynamics - ANSWER ✔✔the study of how medications
change the body; what medications do & how they do it
pharmacokinetics - ANSWER ✔✔the study of medication movement
throughout the body
pharmacokinetics: absorption - ANSWER ✔✔-site of administration --
- through cell membranes to circulation
-occurs in gi tract
pharmacokinetics: distribution - ANSWER ✔✔-transport of
medications throughout the body after absorption of injection
-occurs in circulation
pharmacokinetics: metabolism - ANSWER ✔✔-the biotransformation
of medications to a form which is more easily removed from the body
,-occurs in liver
pharmacokinetics: excretion - ANSWER ✔✔the removal of drugs
from the body
-occurs in the kidney
impact of pregnancy on pharmacokinetics - ANSWER ✔✔-altering
drug absorption, distribution, metabolism, & excretion due to major
physiological changes.
-these changes include:
-increased blood volume, changes in protein binding, altered kidney
function, & modifications to drug-metabolizing enzymes
impact of aging on pharmacokinetics - ANSWER ✔✔higher or lower
drug concentrations & increase the risk of adverse drug reactions
(ADRs) & toxicity in older adults
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, cytochrome P450 - ANSWER ✔✔a superfamily of enzymes that
primarily function to metabolize a wide range of compounds, including
drugs, toxins, steroids, & fatty acids
carbohydrates - ANSWER ✔✔the starches and sugars present in
foods; 45-65% is recommended for daily calorie intake
proteins - ANSWER ✔✔essential macromolecules made of amino
acid chains that perform a wide range of functions in the body, from
building tissues like muscles & hair to acting as enzymes & antibodies
lipids - ANSWER ✔✔a diverse group of organic compounds,
including fats, oils, & waxes, that are insoluble in water but soluble in
organic solvents
vitamins - ANSWER ✔✔compounds that help regulate many vital
body processes, including the digestion, absorption, & metabolism of
other nutrients
water-soluble vitamins - ANSWER ✔✔vitamin c & all b vitamins
fat-soluble vitamins - ANSWER ✔✔-vitamin a
-vitamin d
-vitamin e