, Corticosteroids
The term ‘corticosteroid’ or ‘corticoid’ includes natural
gluco- and mineralo-corticoids and their synthetic
analogues.
Simplified depiction of the pathways of adrenal steroid hormone biosynthesis
, Mineralocorticoid actions
Mineralocorticoid affects on Na+, K+ and fluid balance.
The principal mineralocorticoid action is enhancement of
Na+ reabsorption in the distal convoluted tubule in
kidney. There is an associated increase in K+ and H+
excretion.
Side effects:
edema
progressive rise in BP
Hypokalemia
Alkalosis
, Glucocorticoid actions
Carbohydrate metabolism This results in:
Inducing hepatic glycogen hyperglycaemia,
synthase (increased glucose resistance to
release from liver) insulin
Promoting gluconeogenesis diabetes-like state
They inhibit glucose
utilization by peripheral
tissues.
This results in:
•Muscle wasting
Protein metabolism •Lympholysis
Catabolic action (Protein •Loss of osteoid from
breakdown) bone
•Thinning of skin
The term ‘corticosteroid’ or ‘corticoid’ includes natural
gluco- and mineralo-corticoids and their synthetic
analogues.
Simplified depiction of the pathways of adrenal steroid hormone biosynthesis
, Mineralocorticoid actions
Mineralocorticoid affects on Na+, K+ and fluid balance.
The principal mineralocorticoid action is enhancement of
Na+ reabsorption in the distal convoluted tubule in
kidney. There is an associated increase in K+ and H+
excretion.
Side effects:
edema
progressive rise in BP
Hypokalemia
Alkalosis
, Glucocorticoid actions
Carbohydrate metabolism This results in:
Inducing hepatic glycogen hyperglycaemia,
synthase (increased glucose resistance to
release from liver) insulin
Promoting gluconeogenesis diabetes-like state
They inhibit glucose
utilization by peripheral
tissues.
This results in:
•Muscle wasting
Protein metabolism •Lympholysis
Catabolic action (Protein •Loss of osteoid from
breakdown) bone
•Thinning of skin
