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COMSAE Phase 2 Form 109 Practice Exam Questions and Correct Answers

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Prepare effectively for the COMSAE Phase 2 Form 109 Practice Exam with this structured set of exam-style questions and accurate answers designed to reflect the format and clinical reasoning level of osteopathic medical board assessments. This resource reinforces high-yield concepts across internal medicine, surgery, pediatrics, obstetrics and gynecology, psychiatry, emergency medicine, and preventive care. It emphasizes diagnosis, patient management, interpretation of clinical findings, and evidence-based decision-making. Ideal for osteopathic medical students preparing for COMLEX-USA Level 2 and COMSAE self-assessment exams seeking improved readiness and performance.

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Institution
COMSAE PHASE 2 FORM 104
Course
COMSAE PHASE 2 FORM 104

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COMSAE PHASE 2 FORM 109 PRACTICE EXAM
QUESTIONS AND CORRECT ANSWERS (VERIFIED
ANSWERS) Q&A 2026 |INSTANT DOWNLOAD PDF

1. A 55-year-old man presents with chest pain radiating to the
left arm. ECG shows ST-elevation in leads II, III, and aVF.
Which artery is most likely occluded?
A. Left anterior descending artery
B. Right coronary artery
C. Circumflex artery
D. Left main coronary artery
Rationale: Inferior wall MI is typically due to RCA occlusion.
Correct answer: B. Right coronary artery


2. A child presents with barking cough and inspiratory stridor.
Which virus is most commonly responsible?
A. RSV
B. Parainfluenza virus
C. Influenza A
D. Adenovirus
Rationale: Croup is most commonly caused by parainfluenza
virus.
Correct answer: B. Parainfluenza virus

,3. A patient has decreased serum calcium and prolonged QT
interval. What hormone is deficient?
A. Calcitonin
B. Parathyroid hormone
C. Aldosterone
D. Cortisol
Rationale: Hypocalcemia results from low PTH levels.
Correct answer: B. Parathyroid hormone


4. Which enzyme is deficient in patients with phenylketonuria
(PKU)?
A. Tyrosinase
B. Phenylalanine hydroxylase
C. Homogentisate oxidase
D. Dopamine β-hydroxylase
Rationale: PKU is due to inability to convert phenylalanine to
tyrosine.
Correct answer: B. Phenylalanine hydroxylase


5. A 30-year-old woman presents with heat intolerance,
weight loss, and exophthalmos. Which antibody is most likely
present?
A. Anti-thyroglobulin
B. Anti-TSH receptor
C. Anti-TPO

,D. Anti-mitochondrial
Rationale: Graves disease is caused by TSH receptor stimulating
antibodies.
Correct answer: B. Anti-TSH receptor


6. What is the most common cause of nephrotic syndrome in
children?
A. Focal segmental glomerulosclerosis
B. Membranous nephropathy
C. Minimal change disease
D. IgA nephropathy
Rationale: Minimal change disease is most common in children.
Correct answer: C. Minimal change disease


7. A patient presents with rust-colored sputum and lobar
pneumonia. Which organism is most likely?
A. Klebsiella pneumoniae
B. Streptococcus pneumoniae
C. Mycoplasma pneumoniae
D. Legionella pneumophila
Rationale: S. pneumoniae causes lobar pneumonia with rusty
sputum.
Correct answer: B. Streptococcus pneumoniae

, 8. Which structure is affected in Bell’s palsy?
A. Trigeminal nerve
B. Facial nerve
C. Glossopharyngeal nerve
D. Vagus nerve
Rationale: Bell’s palsy involves CN VII (facial nerve).
Correct answer: B. Facial nerve


9. A patient has a “ground-glass” appearance on lung biopsy.
Which disease is most likely?
A. Sarcoidosis
B. Pneumocystis jirovecii pneumonia
C. Tuberculosis
D. Silicosis
Rationale: PCP shows ground-glass appearance in
immunocompromised patients.
Correct answer: B. Pneumocystis jirovecii pneumonia


10. Which vitamin deficiency causes Wernicke
encephalopathy?
A. Vitamin B6
B. Vitamin B1
C. Vitamin B12
D. Vitamin E
Rationale: Thiamine deficiency leads to Wernicke

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Institution
COMSAE PHASE 2 FORM 104
Course
COMSAE PHASE 2 FORM 104

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Uploaded on
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Number of pages
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Written in
2025/2026
Type
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