COMSAE PHASE 1 FORM 101 (SIMILAR TO COMLEX
LEVE 1 TEST) EXAM QUESTIONS AND CORRECT
ANSWERS (VERIFIED ANSWERS) Q&A 2026
|INSTANT DOWNLOAD PDF
1. A 65-year-old man presents with chest pain radiating to the
left arm. ECG shows ST elevation in leads II, III, and aVF.
Which coronary artery is most likely occluded?
A. Left anterior descending artery
B. Right coronary artery
C. Left circumflex artery
D. Posterior descending artery
Rationale: Inferior wall MI is classically associated with RCA
occlusion in most patients.
Correct Answer: B. Right coronary artery
2. Which vitamin deficiency is associated with Wernicke-
Korsakoff syndrome?
A. Vitamin B1 (Thiamine)
B. Vitamin B6 (Pyridoxine)
C. Vitamin B12 (Cobalamin)
D. Vitamin C (Ascorbic acid)
Rationale: Thiamine deficiency causes neurologic dysfunction,
especially in alcohol use disorder.
Correct Answer: A. Vitamin B1 (Thiamine)
,3. A patient has metabolic acidosis with respiratory
compensation. Which expected finding is most likely?
A. Increased pH and increased HCO₃⁻
B. Decreased pH and decreased HCO₃⁻
C. Increased pH and decreased CO₂
D. Normal pH and increased CO₂
Rationale: Metabolic acidosis shows low pH and low
bicarbonate.
Correct Answer: B. Decreased pH and decreased HCO₃⁻
4. Which structure is derived from the third pharyngeal
pouch?
A. Thyroid gland
B. Parathyroid inferior glands
C. Parathyroid superior glands
D. Thymus
Rationale: Third pouch forms inferior parathyroids and thymus.
Correct Answer: D. Thymus
5. Which neurotransmitter is decreased in Parkinson disease?
A. Serotonin
B. Dopamine
,C. Acetylcholine
D. GABA
Rationale: Degeneration of substantia nigra reduces dopamine.
Correct Answer: B. Dopamine
6. A patient presents with jaundice and dark urine. Lab shows
unconjugated hyperbilirubinemia. What is most likely
impaired?
A. Bile duct obstruction
B. Hepatic conjugation of bilirubin
C. Renal excretion of bilirubin
D. Hemoglobin synthesis
Rationale: Unconjugated bilirubin indicates defective
conjugation (liver issue).
Correct Answer: B. Hepatic conjugation of bilirubin
7. Which hypersensitivity reaction is mediated by IgE?
A. Type I
B. Type II
C. Type III
D. Type IV
Rationale: Type I is immediate hypersensitivity (allergy,
asthma).
Correct Answer: A. Type I
, 8. Which enzyme is deficient in phenylketonuria (PKU)?
A. Tyrosinase
B. Phenylalanine hydroxylase
C. Homogentisate oxidase
D. Galactose-1-phosphate uridyltransferase
Rationale: PKU results from inability to convert phenylalanine
to tyrosine.
Correct Answer: B. Phenylalanine hydroxylase
9. Which part of the nephron is responsible for the majority of
sodium reabsorption?
A. Collecting duct
B. Distal convoluted tubule
C. Proximal convoluted tubule
D. Loop of Henle (descending limb)
Rationale: PCT reabsorbs ~65% of Na⁺.
Correct Answer: C. Proximal convoluted tubule
10. Which organism is most commonly associated with peptic
ulcer disease?
A. Clostridium difficile
B. Helicobacter pylori
LEVE 1 TEST) EXAM QUESTIONS AND CORRECT
ANSWERS (VERIFIED ANSWERS) Q&A 2026
|INSTANT DOWNLOAD PDF
1. A 65-year-old man presents with chest pain radiating to the
left arm. ECG shows ST elevation in leads II, III, and aVF.
Which coronary artery is most likely occluded?
A. Left anterior descending artery
B. Right coronary artery
C. Left circumflex artery
D. Posterior descending artery
Rationale: Inferior wall MI is classically associated with RCA
occlusion in most patients.
Correct Answer: B. Right coronary artery
2. Which vitamin deficiency is associated with Wernicke-
Korsakoff syndrome?
A. Vitamin B1 (Thiamine)
B. Vitamin B6 (Pyridoxine)
C. Vitamin B12 (Cobalamin)
D. Vitamin C (Ascorbic acid)
Rationale: Thiamine deficiency causes neurologic dysfunction,
especially in alcohol use disorder.
Correct Answer: A. Vitamin B1 (Thiamine)
,3. A patient has metabolic acidosis with respiratory
compensation. Which expected finding is most likely?
A. Increased pH and increased HCO₃⁻
B. Decreased pH and decreased HCO₃⁻
C. Increased pH and decreased CO₂
D. Normal pH and increased CO₂
Rationale: Metabolic acidosis shows low pH and low
bicarbonate.
Correct Answer: B. Decreased pH and decreased HCO₃⁻
4. Which structure is derived from the third pharyngeal
pouch?
A. Thyroid gland
B. Parathyroid inferior glands
C. Parathyroid superior glands
D. Thymus
Rationale: Third pouch forms inferior parathyroids and thymus.
Correct Answer: D. Thymus
5. Which neurotransmitter is decreased in Parkinson disease?
A. Serotonin
B. Dopamine
,C. Acetylcholine
D. GABA
Rationale: Degeneration of substantia nigra reduces dopamine.
Correct Answer: B. Dopamine
6. A patient presents with jaundice and dark urine. Lab shows
unconjugated hyperbilirubinemia. What is most likely
impaired?
A. Bile duct obstruction
B. Hepatic conjugation of bilirubin
C. Renal excretion of bilirubin
D. Hemoglobin synthesis
Rationale: Unconjugated bilirubin indicates defective
conjugation (liver issue).
Correct Answer: B. Hepatic conjugation of bilirubin
7. Which hypersensitivity reaction is mediated by IgE?
A. Type I
B. Type II
C. Type III
D. Type IV
Rationale: Type I is immediate hypersensitivity (allergy,
asthma).
Correct Answer: A. Type I
, 8. Which enzyme is deficient in phenylketonuria (PKU)?
A. Tyrosinase
B. Phenylalanine hydroxylase
C. Homogentisate oxidase
D. Galactose-1-phosphate uridyltransferase
Rationale: PKU results from inability to convert phenylalanine
to tyrosine.
Correct Answer: B. Phenylalanine hydroxylase
9. Which part of the nephron is responsible for the majority of
sodium reabsorption?
A. Collecting duct
B. Distal convoluted tubule
C. Proximal convoluted tubule
D. Loop of Henle (descending limb)
Rationale: PCT reabsorbs ~65% of Na⁺.
Correct Answer: C. Proximal convoluted tubule
10. Which organism is most commonly associated with peptic
ulcer disease?
A. Clostridium difficile
B. Helicobacter pylori
