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CORE DOMAINS*
• Osteopathic Principles and Practice*
• Internal Medicine*
• Surgery*
• Pediatrics*
• Obstetrics and Gynecology*
• Psychiatry and Behavioral Health*
, • Preventive Medicine and Public Health*
• Pharmacology and Therapeutics*
• Ethics and Professional Standards*
• Emergency Medicine and Critical Care*
INTRODUCTION*
The COMSAE Form 113 practice examination is designed to evalu
SECTION ONE: QUESTIONS 1–50
1. A 62-year-old man presents with crushing substernal chest pain radiating to his left
arm for 45 minutes. ECG reveals ST-segment elevation in leads II, III, and aVF. Which
coronary artery is most likely occluded?
A. Left anterior descending artery
B. Right coronary artery
,C. Circumflex artery
D. Posterior descending artery
🟢 Correct Answer: B. Right coronary artery
🔴 Explanation: Inferior wall myocardial infarctions involving leads II, III, and aVF are most
commonly caused by occlusion of the right coronary artery.
2. A 5-year-old child presents with barking cough, inspiratory stridor, and hoarseness
that worsens at night. Which diagnosis is most likely?
A. Epiglottitis
B. Foreign body aspiration
C. Croup
D. Asthma
🟢 Correct Answer: C. Croup
🔴 Explanation: Croup commonly presents with a barking cough, inspiratory stridor, and
hoarseness due to viral inflammation of the upper airway.
3. A patient with diabetes mellitus develops microalbuminuria. Which medication is
most appropriate to slow progression of diabetic nephropathy?
A. Hydrochlorothiazide
B. Metoprolol
, C. Amlodipine
D. Lisinopril
🟢 Correct Answer: D. Lisinopril
🔴 Explanation: ACE inhibitors such as lisinopril reduce intraglomerular pressure and slow
progression of diabetic nephropathy.
4. Which cranial nerve is primarily responsible for sensation over the face?
A. Facial nerve
B. Trigeminal nerve
C. Glossopharyngeal nerve
D. Hypoglossal nerve
🟢 Correct Answer: B. Trigeminal nerve
🔴 Explanation: The trigeminal nerve provides the major sensory innervation to the face
through its three branches.
5. A 28-year-old woman presents with exophthalmos, heat intolerance, and weight loss.
Which condition is most likely?
A. Hashimoto thyroiditis
B. Graves disease