UTA Advanced Pharmacology Exam 3 UPDATED
ACTUAL Questions and CORRECT Answers
Diagnosis of Diabetes - CORRECT ANSWER -Fasting blood sugar >126
Random blood sugar > 200
Oral glucose tolerance test >200
Insulin Lispro (Humalog) - CORRECT ANSWER -Rapid-acting analog of regular insulin
Onset: 15 to 30 minutes after subcutaneous (subQ) injection
Duration: 3 to 6 hours
Should be injected 5 to 10 minutes before meals
Insulin glulisine (Apidra) - CORRECT ANSWER -Synthetic analog of natural human insulin
Rapid onset (10 to 15 min)
Short duration (3 to 5 hr)
Regular insulin (Humulin R, Novolin R) - CORRECT ANSWER -Short-acting insulin
Effects begin in 30 to 60 minutes
Peak in 1 to 5 hours
Duration up to 10 hours
U-100 (100 units/mL)
U-500 (500 units/mL)
NPH insulin (Humulin N, Novolin N) - CORRECT ANSWER -Drug is injected twice or three times daily to
provide glycemic control
Insulin glargine [Lantus] - CORRECT ANSWER -Prolonged duration of action (up to 24 hr)
Insulin detemir [Levemir] - CORRECT ANSWER -At low doses (0.2 units/kg), effects persist about 12 hours. At
higher doses (0.4 units/kg), effects persist for up to 20 to 24 hours.
Degludec (Tresiba) - CORRECT ANSWER -ultra long acting insulin (42 hrs)
Metformin [Glucophage] - CORRECT ANSWER -inhibits glucose production in the liver
reduces (slightly) glucose absorption in the gut.
sensitizes insulin receptors in target tissues
Most common side effects: Gastrointestinal (GI) disturbances
Lactic Acidosis (CKD)
Sulfonylureas: First Generation - CORRECT ANSWER -Chlorpropamide [Diabinese]
Tolazamide [Tolinase]
Tolbutamine [Orinase]
Sulfonylureas Second Generation - CORRECT ANSWER -Glimepiride
Glipizide
Glyburide
Sulfonureas - CORRECT ANSWER -drug: DM2 pt -> block K-ATP chan -> inc intracell K+ -> depol -> Ca2+
influx -> make insulin
Meglitinides (Glinides) MOA - CORRECT ANSWER -Bind K channel in beta cell (different binding spot than
sulfonylureas)-->insulin release
SE = wt gain; hypoglycemia
Meglitinides (Glinides) - CORRECT ANSWER -Repaglinide (Prandin)
Nateglinide (Starlix)
ACTUAL Questions and CORRECT Answers
Diagnosis of Diabetes - CORRECT ANSWER -Fasting blood sugar >126
Random blood sugar > 200
Oral glucose tolerance test >200
Insulin Lispro (Humalog) - CORRECT ANSWER -Rapid-acting analog of regular insulin
Onset: 15 to 30 minutes after subcutaneous (subQ) injection
Duration: 3 to 6 hours
Should be injected 5 to 10 minutes before meals
Insulin glulisine (Apidra) - CORRECT ANSWER -Synthetic analog of natural human insulin
Rapid onset (10 to 15 min)
Short duration (3 to 5 hr)
Regular insulin (Humulin R, Novolin R) - CORRECT ANSWER -Short-acting insulin
Effects begin in 30 to 60 minutes
Peak in 1 to 5 hours
Duration up to 10 hours
U-100 (100 units/mL)
U-500 (500 units/mL)
NPH insulin (Humulin N, Novolin N) - CORRECT ANSWER -Drug is injected twice or three times daily to
provide glycemic control
Insulin glargine [Lantus] - CORRECT ANSWER -Prolonged duration of action (up to 24 hr)
Insulin detemir [Levemir] - CORRECT ANSWER -At low doses (0.2 units/kg), effects persist about 12 hours. At
higher doses (0.4 units/kg), effects persist for up to 20 to 24 hours.
Degludec (Tresiba) - CORRECT ANSWER -ultra long acting insulin (42 hrs)
Metformin [Glucophage] - CORRECT ANSWER -inhibits glucose production in the liver
reduces (slightly) glucose absorption in the gut.
sensitizes insulin receptors in target tissues
Most common side effects: Gastrointestinal (GI) disturbances
Lactic Acidosis (CKD)
Sulfonylureas: First Generation - CORRECT ANSWER -Chlorpropamide [Diabinese]
Tolazamide [Tolinase]
Tolbutamine [Orinase]
Sulfonylureas Second Generation - CORRECT ANSWER -Glimepiride
Glipizide
Glyburide
Sulfonureas - CORRECT ANSWER -drug: DM2 pt -> block K-ATP chan -> inc intracell K+ -> depol -> Ca2+
influx -> make insulin
Meglitinides (Glinides) MOA - CORRECT ANSWER -Bind K channel in beta cell (different binding spot than
sulfonylureas)-->insulin release
SE = wt gain; hypoglycemia
Meglitinides (Glinides) - CORRECT ANSWER -Repaglinide (Prandin)
Nateglinide (Starlix)
