APHA IMMUNIZATION TRAINING
CERTIFICATION REVIEW 2026 QUESTIONS
WITH SOLUTIONS GRADED A+
●● Which of the following diseases have been eradicated worldwide,
allowing vaccination to be discontinued? Answer: Smallpox
●● Which of the following is one of the five guidelines identified by the
APhA Board of Trustees in 2019 to assist pharmacists in incorporating
immunization activities into their practice? Answer: Prevention
●● Opportunities for Advocacy and Collaboration include: Answer:
Membership in state immunization coalition to serve as an expert on
policy and practice issues affecting pharmacy
●● Which of the following is an example of passive immunity?
a) contracting measles
b) maternal antibodies
c) Hepatitis B vaccine
d) skin barrier Answer: b) maternal antibodies
●● Children less than what age do not mount an adequate immune
response to T-cell independent immunity?
,a) 5 years
b) 11 years
c) 2 years
d) 18 years Answer: c) 2 years
●● How long does it take for the immune system to provide protection
by producing disease-specific antibodies and memory cells?
a) 21 days
b) 7 days
c) 5 days
d) 14 days Answer: d) 14 days
●● The National Vaccine Advisory Committee 2013 Standards for Adult
Immunization Practice and the 2016 International Pharmaceutical
Federation global report identify pharmacists as: Answer: Integral to
increasing vaccination rates
●● Which of the following is found in vaccines to evoke an immune
response?
a) antigens
b) antibodies
c) macrophages
d) B cells Answer: a) antigens
,●● Why is spacing and timing of vaccines important?
a) memory T-cells interfere with immune response
b) circulating antibodies may interfere with immune response
c) antibodies interfere with inactive vaccines
d) antigen load may interfere with immune response Answer: b)
circulating antibodies may interfere with immune response
●● Which of the following vaccines listed is a live attenuated vaccine?
a) Varicella (VAR)
b) Recombinant zoster vaccine (RZV)
c) Hepatitis B
d) Hepatitis A Answer: a) Varicella (VAR)
Varicella (VAR) is a live attenuated vaccine. The remaining vaccines
listed are types of inactivated vaccines.
●● Which vaccine technology listed below is an ingredient added
typically to inactivated vaccines to boost its immune response by
targeting pathogen recognition receptors that are expressed on dendritic
cells to trigger a pro-inflammatory response? Though this technology
creates a more robust immune response, it can also increase local site
reactions and systemic reactions, such as fevers, chills, and body aches.
a) Conjugation
, b) Attenuation
c) mRNA technology
d) adjuvants Answer: d) Adjuvants
Adjuvants are developed and patented by manufacturers to produce a
more robust immune response to the vaccine. These ingredients target
types of pathogen recognition receptors that, when activated, trigger a
pro-inflammatory response that enhances the body's adaptive immune
response. Because of the larger pro-inflammatory response, this vaccine
technology will not only provide a stronger immune response but also
increase the likelihood of local and systemic reactions.
●● Which of the following is true regarding the use of mRNA in vaccine
technology?
a) mRNA vaccine technology requires replication similar to a live
attenuated vaccine.
b) mRNA vaccine technology elicits its immune response and protects
the host by altering the host's DNA
c) mRNA is the genetic blueprint that tells your body how to make a
particular protein subunit of a virus which, after being produced, will
elicit an immune response.
d) mRNA is extremely stable in a host's body. Answer: c) mRNA is the
genetic blueprint that tells your body how to make a particular protein
subunit of a virus which, after being produced, will elicit an immune
response.
CERTIFICATION REVIEW 2026 QUESTIONS
WITH SOLUTIONS GRADED A+
●● Which of the following diseases have been eradicated worldwide,
allowing vaccination to be discontinued? Answer: Smallpox
●● Which of the following is one of the five guidelines identified by the
APhA Board of Trustees in 2019 to assist pharmacists in incorporating
immunization activities into their practice? Answer: Prevention
●● Opportunities for Advocacy and Collaboration include: Answer:
Membership in state immunization coalition to serve as an expert on
policy and practice issues affecting pharmacy
●● Which of the following is an example of passive immunity?
a) contracting measles
b) maternal antibodies
c) Hepatitis B vaccine
d) skin barrier Answer: b) maternal antibodies
●● Children less than what age do not mount an adequate immune
response to T-cell independent immunity?
,a) 5 years
b) 11 years
c) 2 years
d) 18 years Answer: c) 2 years
●● How long does it take for the immune system to provide protection
by producing disease-specific antibodies and memory cells?
a) 21 days
b) 7 days
c) 5 days
d) 14 days Answer: d) 14 days
●● The National Vaccine Advisory Committee 2013 Standards for Adult
Immunization Practice and the 2016 International Pharmaceutical
Federation global report identify pharmacists as: Answer: Integral to
increasing vaccination rates
●● Which of the following is found in vaccines to evoke an immune
response?
a) antigens
b) antibodies
c) macrophages
d) B cells Answer: a) antigens
,●● Why is spacing and timing of vaccines important?
a) memory T-cells interfere with immune response
b) circulating antibodies may interfere with immune response
c) antibodies interfere with inactive vaccines
d) antigen load may interfere with immune response Answer: b)
circulating antibodies may interfere with immune response
●● Which of the following vaccines listed is a live attenuated vaccine?
a) Varicella (VAR)
b) Recombinant zoster vaccine (RZV)
c) Hepatitis B
d) Hepatitis A Answer: a) Varicella (VAR)
Varicella (VAR) is a live attenuated vaccine. The remaining vaccines
listed are types of inactivated vaccines.
●● Which vaccine technology listed below is an ingredient added
typically to inactivated vaccines to boost its immune response by
targeting pathogen recognition receptors that are expressed on dendritic
cells to trigger a pro-inflammatory response? Though this technology
creates a more robust immune response, it can also increase local site
reactions and systemic reactions, such as fevers, chills, and body aches.
a) Conjugation
, b) Attenuation
c) mRNA technology
d) adjuvants Answer: d) Adjuvants
Adjuvants are developed and patented by manufacturers to produce a
more robust immune response to the vaccine. These ingredients target
types of pathogen recognition receptors that, when activated, trigger a
pro-inflammatory response that enhances the body's adaptive immune
response. Because of the larger pro-inflammatory response, this vaccine
technology will not only provide a stronger immune response but also
increase the likelihood of local and systemic reactions.
●● Which of the following is true regarding the use of mRNA in vaccine
technology?
a) mRNA vaccine technology requires replication similar to a live
attenuated vaccine.
b) mRNA vaccine technology elicits its immune response and protects
the host by altering the host's DNA
c) mRNA is the genetic blueprint that tells your body how to make a
particular protein subunit of a virus which, after being produced, will
elicit an immune response.
d) mRNA is extremely stable in a host's body. Answer: c) mRNA is the
genetic blueprint that tells your body how to make a particular protein
subunit of a virus which, after being produced, will elicit an immune
response.
