Chem 1005 Final Exam Questions And Answers |
Latest Update 2026/2027 | Graded A+.
In the fasted state, fatty acyl-CoAs are transported across the mitochondrial membrane. The transport of
fatty acids via carnitine palmitoyl transferase 1 can be directly inhibited by which of the following
compounds? - Answer--Malonyl-CoA
An individual is on a hunger strike and has not eaten in 13 days. Which of the following best describes
their metabolic state? - Answer--The brain will be preferentially oxidizing ketones.
Ketonuria, hyperglycemia and severe acidosis are prime diagnostic indicators of the presentation of type 1
diabetes ketoacidosis. Which of the following compounds are ketone bodies that would be elevated in
serum and urine of a patient in this condition? - Answer--D-3-hydroxybutyrate and acetoacetate
A 10-year old boy is brought to the emergency department by his father. He reports his son has recently
been very thirsty and needing to make frequent trips to the bathroom. Physical examination revealed a
thin boy, in the 30th percentile for height and weight. A rapid dipstick test revealed glucose in his urine.
Evaluation of this boys blood would reveal decreased levels of which of the following compounds or
hormones? - Answer--Insulin
A 22-year old woman engaging in a political protest goes on a hunger strike on a prominent corner in a
city park. She refuses all offers of food except for water through the first 2 weeks. Under these conditions
there is a decreased reliance on which of the following pathways for fuel? - Answer--Gluconeogenesis
Which of the following is not a product of B-oxidation? - Answer--NADPH
ATP can be generated by many metabolic pathways in the body. Which of the following processes
generated the most ATP? - Answer--Fatty acid B-oxidation
Which of the following is the regulated step of lipogenesis in eukaryotes? - Answer--Carboxylation of
acetyl-CoA
,Under fasting conditions, acetyl CoA carboxylase will be inhibited by an increase in which of the
following compounds? - Answer--Fatty acyl-CoA
Which of the following is the regulatory enzyme for fatty acid synthesis? - Answer--Acetyl CoA
carboxylase
In the case of deficiency of biotin, which of the following enzymes required for fatty acid metabolism will
be impaired? - Answer--Acetyl-CoA carboxylase
NADPH is essential for fatty acid synthesis can be generated by which of the following enzymes? -
Answer--Glucose 6 phosphate dehydrogenase and malic enzyme
Shortly after meal high in fat, you would expect an elevation of which of the follow lipoproteins in
circulation? - Answer--Chylomicrons
A 45-year-old man is found to have an elevated serum triglycerides of > 730mg/dL. He tells you he forgot
to fast before his visit and he ate a full breakfast of bacon and eggs before the labs were drawn. Which of
the following lipoproteins would be the largest contributors to a measurement of plasma triglycerides in
this situation? - Answer--Chylomicrons and VLDLs
The interaction of chylomicrons with lipoprotein lipase is stimulated by which of the following Apo
proteins? - Answer--ApoC II
A 45-year-old man is found to have an elevated serum cholesterol of 300mg/dL after a 12 hr. fast. Which
of the following lipoproteins would be the largest contributors to a measurement of plasma cholesterol in
a normal person following a 12 hr. fast? - Answer--High-density lipoproteins (HDLs) and LDLs
, Which of the following enzymes is correctly paired with its allosteric inhibitor? - Answer--Acetyl-CoA
carboxylase : palmitoyl-CoA
In liver, which of the following key inhibitory events ensures that newly synthesized will palmitoyl-CoA
is not immediately oxidized? - Answer--Inhibition of carnitine palmitoyl transferase 1 by malonyl-CoA
Under conditions when glucose oxidation is elevated, the acetyl-CoA produced will allosterically activate
which of the following enzymes leading to an increase in the production of oxaloacetate? - Answer-
Pyruvate carboxylase
Which of the following best describes the role of HDL particles? - Answer--HDL particles are required
for the transport of cholesterol from peripheral tissues to the liver
Which lipoprotein is responsible for the process of reverse cholesterol transport (the movement of
cholesterol from the peripheral tissues back to the liver)? - Answer--HDL
An increase in the ratio of insulin to glucagon will increase the activity in of which of the following
enzymes? - Answer--Acetyl-CoA carboxylase, phosphofructokonase 2 and glycogen synthase (hormone
sensitive lipase will be decreased)
VLDL particles have which of the following combinations of apoproteins in their mature form? -
Answer--ApoB100, ApoCII, ApoE
When an LDL particle is taken up by the cell, what impact will this have on the regulation of de novo
cholesterol synthesis? - Answer--SREBP will be inhibited by Insig in the endoplasmic reticulum
Which of the following compounds is not synthesized from cholesterol? - Answer--Guanine
A comatose infant is brought to the ER. In the course of the examination, plasma ammonia was found to
be elevated 20-fold over normal values. Urine orotic acid and uracil were both greater than normal. A
Latest Update 2026/2027 | Graded A+.
In the fasted state, fatty acyl-CoAs are transported across the mitochondrial membrane. The transport of
fatty acids via carnitine palmitoyl transferase 1 can be directly inhibited by which of the following
compounds? - Answer--Malonyl-CoA
An individual is on a hunger strike and has not eaten in 13 days. Which of the following best describes
their metabolic state? - Answer--The brain will be preferentially oxidizing ketones.
Ketonuria, hyperglycemia and severe acidosis are prime diagnostic indicators of the presentation of type 1
diabetes ketoacidosis. Which of the following compounds are ketone bodies that would be elevated in
serum and urine of a patient in this condition? - Answer--D-3-hydroxybutyrate and acetoacetate
A 10-year old boy is brought to the emergency department by his father. He reports his son has recently
been very thirsty and needing to make frequent trips to the bathroom. Physical examination revealed a
thin boy, in the 30th percentile for height and weight. A rapid dipstick test revealed glucose in his urine.
Evaluation of this boys blood would reveal decreased levels of which of the following compounds or
hormones? - Answer--Insulin
A 22-year old woman engaging in a political protest goes on a hunger strike on a prominent corner in a
city park. She refuses all offers of food except for water through the first 2 weeks. Under these conditions
there is a decreased reliance on which of the following pathways for fuel? - Answer--Gluconeogenesis
Which of the following is not a product of B-oxidation? - Answer--NADPH
ATP can be generated by many metabolic pathways in the body. Which of the following processes
generated the most ATP? - Answer--Fatty acid B-oxidation
Which of the following is the regulated step of lipogenesis in eukaryotes? - Answer--Carboxylation of
acetyl-CoA
,Under fasting conditions, acetyl CoA carboxylase will be inhibited by an increase in which of the
following compounds? - Answer--Fatty acyl-CoA
Which of the following is the regulatory enzyme for fatty acid synthesis? - Answer--Acetyl CoA
carboxylase
In the case of deficiency of biotin, which of the following enzymes required for fatty acid metabolism will
be impaired? - Answer--Acetyl-CoA carboxylase
NADPH is essential for fatty acid synthesis can be generated by which of the following enzymes? -
Answer--Glucose 6 phosphate dehydrogenase and malic enzyme
Shortly after meal high in fat, you would expect an elevation of which of the follow lipoproteins in
circulation? - Answer--Chylomicrons
A 45-year-old man is found to have an elevated serum triglycerides of > 730mg/dL. He tells you he forgot
to fast before his visit and he ate a full breakfast of bacon and eggs before the labs were drawn. Which of
the following lipoproteins would be the largest contributors to a measurement of plasma triglycerides in
this situation? - Answer--Chylomicrons and VLDLs
The interaction of chylomicrons with lipoprotein lipase is stimulated by which of the following Apo
proteins? - Answer--ApoC II
A 45-year-old man is found to have an elevated serum cholesterol of 300mg/dL after a 12 hr. fast. Which
of the following lipoproteins would be the largest contributors to a measurement of plasma cholesterol in
a normal person following a 12 hr. fast? - Answer--High-density lipoproteins (HDLs) and LDLs
, Which of the following enzymes is correctly paired with its allosteric inhibitor? - Answer--Acetyl-CoA
carboxylase : palmitoyl-CoA
In liver, which of the following key inhibitory events ensures that newly synthesized will palmitoyl-CoA
is not immediately oxidized? - Answer--Inhibition of carnitine palmitoyl transferase 1 by malonyl-CoA
Under conditions when glucose oxidation is elevated, the acetyl-CoA produced will allosterically activate
which of the following enzymes leading to an increase in the production of oxaloacetate? - Answer-
Pyruvate carboxylase
Which of the following best describes the role of HDL particles? - Answer--HDL particles are required
for the transport of cholesterol from peripheral tissues to the liver
Which lipoprotein is responsible for the process of reverse cholesterol transport (the movement of
cholesterol from the peripheral tissues back to the liver)? - Answer--HDL
An increase in the ratio of insulin to glucagon will increase the activity in of which of the following
enzymes? - Answer--Acetyl-CoA carboxylase, phosphofructokonase 2 and glycogen synthase (hormone
sensitive lipase will be decreased)
VLDL particles have which of the following combinations of apoproteins in their mature form? -
Answer--ApoB100, ApoCII, ApoE
When an LDL particle is taken up by the cell, what impact will this have on the regulation of de novo
cholesterol synthesis? - Answer--SREBP will be inhibited by Insig in the endoplasmic reticulum
Which of the following compounds is not synthesized from cholesterol? - Answer--Guanine
A comatose infant is brought to the ER. In the course of the examination, plasma ammonia was found to
be elevated 20-fold over normal values. Urine orotic acid and uracil were both greater than normal. A
