Pharmaceutical Calculations and Techniques 100/ 100 scored questions and answers

lOMoARcPSD| Pharmaceutical Calculations and Techniques 100/ 100 scored questions and answers (Pharmaceutical Calculations) 1. How many millilitres of a 10%m KCL (MWt. 74.6) solution contain 5mEq of K+? a. 2.10 mL b. 21mL c. 3.73 mL d. 37.3 mL e. 0.373 mL 2. The physician changes the order to read “Give 500 mg of dopamine in 500 mL of D5W at a rate of 3.6 mcg/kg/minute”. What is the current flow rate in millilitres per hour? a. 12 mL/hr b. 15 mL/hr c. 30 mL/hr d. 45 mL/hr e. 40 mL/hr 3. You have 500 mL D5W to which you add 400 mg of dopamine. This is to infuse at 400 mcg/min IV. What is the flow rate? a. 24 mL/hr b. 19.2 mL.hr c. 30 mL/hr d. 24 mg/hr e. 24,000mcg/hr 4. A 5% solution of hydrogen peroxide has been prepared by the pharmacist. If the total amount prepared is 10 mL, how many mL are pure drug? a. 0.5 mL b. 5 mL c. 2 mL d. 1.5 mL e. 0.05 mL 5. A physician prescribe 0.3 g of simethicone total daily to be administered in four equally divided doses. Simethicone comes in 20 mg, 25 mg, 40 mg, 60 mg-tabs. How many tabs, of which strength, should you administer per dose? a. 3-20 mg tabs b. 3-25 mg tabs c. 2-40 mg tabs d. 160 mg tabs e. Divide the 60 mg tabs 6. Glycerin has a specific gravity of 1.25. One gallon weighs: a. 591.25 g b. 473 g c. 4730 g d. 128 g e. 4800 g 7. The amount of 190 proof required to make 500 mL of 70% alcohol is: a. 350 mL b. 520 mL c. 184 mL d. 368 mL e. 37 mL 8. If a buffer solution is prepared using equal concentrations of acetic acid and sodium acetate, the pH would then be: a. 1 b. 14 c. Equal to the pKa d. Equal to ½ of the pKa e. Equal to the double of the pKa 9. If the adult dose of furosemide (Lasix) is 49 mg, what is the dose for a child whose BSA is 0.53m2? a. 12.256 mg b. 12.4 mg c. 12.254 mg d. None of the above e. All of the above 10. An IV piggyback of cefazolin sodium 500 mg in 100 mL/hr is ordered. The Piggyback IV set is calibrated to deliver 10 gtt/mL. How many drops per minute should be administered? a. 14 gtt/min b. 1.7 gtt/min c. 0.17 gtt/min d. 2 gtt/min e. 15 gtt/min 11. An order calls for 500 mL of a solution of potassium sulphate (K=39 S=32 0=16) a. 0.440 g b 4.44 g c. 0.044 g d. 0.870 g e. 8.70 g 12. The abbreviation SOS on prescription means: a. at once b. freely c. If needed d. Do not repeat e. On alternate days 13. What is the proof strength of a 50% (v/v) solution of alcohol? a. 25 proof b. 50 proof c. 100 proof d. 75 proof e. 150 proof 14. An ointment is prepared by incorporating 10 g of a drug into a 100 g of white petrolatum. What is the percent w/w of active ingredient? a. 10 % b. 9.1 % c. 0.41 % d. 0.95 % e. None of the above 15. The latinoculoutro is translated to mean: a. Right eye b. Each eye c. Left eye d. Each ear e. Right ear 16. The physician orders 3.3 mg/m2 of the oral form of methotrexate, an antineoplastic, for a patient whose BSA is 0.9m2. Which dose is correct? a. 3 mg b. 3.7 mg c. 10.2 mg d. 12.5 mg e. 1.72 mg 17. -12⁰C is equivalent to: a. 36⁰F b. 12⁰F c. 10.4⁰F d. 5⁰F e. -2⁰F 18. A to a drug is to be administered to a 187 lb patient. The order calls for a 50 mg/kg body mass. The drug is to be administered in two equally divided doses. How many g per dose should be administered? a. 4250 mg/dose b. 4.25 g/dose c. 4 g/dose d. 2.1 g/dose e. 2125 mg/dose 19. Cimetidine is a drug that can produce side effects such as dizziness and a rash. The number of people who experience these side effects is about 1% of all those who take the drug. If 1500 people take cimetidine, how many persons are expected to experience the side effects? a. 15 people b. 10 people c. 2 people d. 10 people e. 5 people 20. A 44 kg child has been ordered to receive a dose of cortisone acetate. If the adult dose is 150 mg, what will the child’s dose be? (use Clark’s Rule) a. 97.1 mg b. 96.8 mg c. 96.77 mg d. All of the above e. Both a and b 21. ORDER: 50,000 units of penicillin G potassium per kg body mass per day, to be administered in four equally divided doses. Penicillin G potassium 500,000 unit tabs are available. How many tabs will a 176 lb patient receive? a. 1 tab b. 2 tabs c. 3 tabs d. ½ tab e. 2 ½ tabs 22. Calcium gluconate (C12H22CaO14-MWt.=430_ injection 10% is available in a 10 mL ampul. How many milliequivalent of Ca++ does the ampul contain? a. 4.65 mEq b. 465 mEq c.465.12meq d.0.465meq e. 2.33 mEq 23. How many millilitres of 95% w/w sulfuric acid having a specific gravity of 1.820 should be used in preparing 2L of 1% w/v acid? a. 210.53 mL of 95% b. 383.16 mL of 95% c. 1098.90 mL of 95% d. 115.67 mL of 95% e. 0.1157 mL of 95% 24. If a diabetic patient injects 20 units of insulin twice daily, how many days will a 10 mL vial of the U-100 product last the patient? a. 50 days b. 4 days c. 2 days d. 2 ½ days e. 25 days 25. How many grams of azelaic acid are contained in 30 g tubes of the 15% w/w ointment? a. 2 g b. 0.005 g c. 4.5 g d. 0.15 g e. 225 g 26. A pharmacist attempts to weigh 120 mg of codeine sulfate on a balance with a sensitivity requirements of 6mg. Calculate the maximum potential error in terms of percentage. a. 5% b. 2 % c. 0.83% d. 1 % e. .2 % 27. If a biologic product contains 7.5 Lf Units of diphtheria toxoid per 0.5 mL, how many flocculating units would be present in a 7.5 mL multiple dose vial? a. 112.5 Lf Units b. 11.25 Lf Units c. 0.5 Lf Units d. 56.25 Lf Units e. 28.13 Lf Units 28. A pharmacist is required to provide 75 mL of glycerol. A suitable measure is not available. What weight of glycerin is equivalent to 75 mL? Assume that the density of glycerol is 1.25g/mL. a. 60 g b. 93.75 g c. 0.02 g d. 73.75 g e. 20 g 29. What weight of potassium permanganate is required to produce 30 mL od solution such that 5 mL of this solution diluted to 25 mL gives a 0.01 % w/v solution? a. 0.5 g b 150 g c. 30 g d. 15 g e. 1.5 g 30. Calculate the number of tablets required for one week, if 12 tablets are used each day. a. 12 d. 86 b. 2 e. 84 c. 4 31. Calculate the BMI for a person weighing 182 lb and standing 72 in in height. a. 24.58 b. 24.73 c. 1.78 d. 12.82 e. 24 32. In a clinical study, a drug produces drowsiness in a 3 of the 1500 patients studied. How many patients of a certain pharmacy could expect similar effects based on a patient count of 100? a. 30 b. 2 c. 6 d. 5 e. 15 33. How many millilitres of a 5 % w/v solution can be made from 300 mL of 3% w/v solution? a. 1800 mL b. 50 mL c. 1500 mL d. 1740 mL e. 1000 mL 34. Calculate the amount of phenol in the following formula: Phenol % v/v Water to 30mL a. 0.6 mL b. 0.6 g c. 1.5 mL d. 1740 mL e. 6 mL 35. The adult dose of a drug is 250 mg. What would be the approximate dose for a 6 year old child weighing 60 lb? (Use Young’s Rule) a. 60 mg b. 85 mg c.100mg d.125 mg e. 180 mg 36. How many mL of triamcinolone acetonide aqueous injection (40mg/mL) could be used to prepare 240 mL of the formula? a. 6.3 mL b. 12.5 mL c. 1.2 mL d. 10 mL e. 15 mL 37. The concentration of mercury in a water sample is reported as 5 ppm. Express this concentration as a percentage. a. 0.00005 % b. 0.0005 % c. 0.005% d. 0.05% e. 0.5 % 38. An ICU medical order reads “KCl 40 mEq in 1 liter N/S. Infuse at 0.5 mEq/min.” How many minutes will this bottle last on the patient. a. 20 b. 60 c. 500 d. 1000 e. 2000 39. Estimate the milliosmolarity (mOsm/L) for a normal saline. (Na=23 ;Cl=35.5) a. 150 mOsm/L b. 300 mOsm/L c. 350 mOsm/L d. 400 mOsm/L e. 600 mOsm/L 40. The USP contains nomograms for estimating body surface area (BSA) for both children and adults. Which of the foillowing measurements must be known in order to use the nomogram? a. Age and height b. Age and weight c. Height and creatinine clearance d. Height and weight e. Weight and sex 41. How many L of a 10% Lysol solution are needed to prepare 1 L of a 3% Lysol solution? a. 0.03 L b. 30 L c. 15 L d. 0.3 L e. 7 L 42. MCDXCIX is equivalent to: a. 1999 b. 2499 c.1499 d. 1099 e. 1409 43. Acyclovir (zovirax) is administered in a dose of 15 mg/kg/day. How many milligrams of the drug must be administered daily to a 175 lb adult? a. 1190 b. 542 c. 271 d. 1193 e. 597 44. What is the final concentration of glucose solution obtained by mixing 100 ml of 5% w/v with 200ml of 4% and 300 ml of 30% w/v? a. 0.058% b.17.17% c. 5.85 d. 1193 e.16% 45. Wool fat is stated as having a melting point range of 36 to 42 degrees Celcius. Express this range in farenheit. a. 95 to 106 b. 90.8 to 100 c. 96.8 to 107.6 d. 98.6 to106.7 e. 96.8 to 106.7 46. What is the ratio strength of a trituration containing 120 mg of a hyoscine with 2.28 g of lactose? a. 1:20 b. 1:005 c. 1:17.86 d. 1:18 e. 1:0.2 47. A 3 yr old child weighing 15 kg requires furosemide at a dose of 2 mg/kg daily. The only available preperation is oral solution containing furosemide 10mg/ml. What volume of the oral solution should be dispensed so that the child has sufficient of 28 days. a. 3ml b.12ml c.30ml d.84ml e.120ml 48. How many grams of an 8% w/w cream must be diluted to produce 150g of a 2.5 % w/w cream? a.46.875g b.480.75g c.468.75g d.48g e.4.8g 49. How many ml of 2% w/v solution of ammonium chloride ( NH4Cl-MWt.=53.5) should be administered intravenously to a patient to provide 75 meq? a. 2.5ml b.0.08ml c.200.6ml d.100.31ml e.2.006ml 50. If a ventoline inhaler contains 20mg of albuterol, how many inhalation doses can delivered if each inhalation dose contains 90mcg.? a. 0dose b.4.5dose c.22.22dose d.45dose e.222dose 51. Rx Sol.Silver Nitrate 0.5% 15 (E=0.33) Make isotonic Solution Sig for eyes How many grams of pottasium nitrate (E0.58) should be used to make the prescription isotonic? a.0.11g b.0.05g c.0.19g d.1.72g e.0.1125g 52. The dose of mitomycin injection is 20 mg/m2 per day. Determine the daily dose for a patient who weights 144 lb and measures 68in. In height (BSA=1.77m2) a.35.4mg b.20.46mg c.19.55mg d.3.54mg e.2.46mg 53. How many mg of aluminum acetate are required to prepare 500 ml of a 0.03 % w/v solution? a.100mg b.0.15mg c.1500mg d.150mg e.15mg 54. What volume of 100 mg/5 ml solution is required to be diluted to gove 200 ml of 75mg/5ml solution? a. 7ml b. 0ml c.0.15ml d.150mg e.15ml 55. A residential home buys a 1000 pack of senna tabets. Each resident is given two tablets each night. There are 35 residents. How long will it take to use all the senna tablets? a. 1/2 days b.28days c.14 days d.29 days e.14.3days 56. Apatientis prescribed analgesic suppositories to be used six times a day for 5 days, then three times a day for 5 days. How many suppositories should the pharmacist dispensed? a.39 b.33 c.9 d.20 e.90 57. A syrup contains 7.5 % of potassium chloride (MWt.=74.5) How many millimoles of K+ are contained in 1 ml of this syrup? a.1.92 millimoles b.1millimole c.0.19millimole d.7.5millimole e.1.8millimole 58. One liter of 0.9% saline solution is to be given to a patient over a 6 period. If 20 drops=1ml, how many drops per minute shuold be administered? a.50drops per minute b.66drops per minute c. 56 drops per minute d.53 drops per minute e.60 drops per minute 59. Teratogenic studies of insulin glargine were undertaken in rats at doses up to 0.36 mg/kg/day. This is equivalent of the following? a.792 mcg/lb/day b.360 mcg/lb/day c.360 mcg/lb/day d.163.6 mcg/lb/day e.792 mcg/lb/day 60. If the wt of 40ml of a liquid is 37.5g what is the density of a liquid in g/ml? a.0.027g/ml b.0.938g/ml c. 0.95g/ml d.0.408g/ml e.1500g/ml c.0.95g/ml 61. Caps i c aq. h.s. NR means: a. Take 1 cap w/ water at bedtime. e. Take 1 capsule with water before meals. b. At bedtime. Do not repeat. c. Take 1 capsule with water at bed time. d. Take 1 capsule without water. Do not repeat. Take 1 capsule with water Do not repeat. 62. A Prescription calls for 0.005g of morphine sulphate. How many milligrams of a 1:10 trituration may be Used to obtain morphine sulphate. a. 0.05g b. 0.5mg c. 5mg d. 5g e. 50mg 63. If the concentration of flouride is 0.25ppmw/v, how many liters would contain of 1mg of flouride? a. 400mL b. 4L c. 4000L d. 0.25 e. 250ml 64. Calculate the Body Mass Index (BMI) for a person measuring 1.7 meters in height and weighing 87 kilograms. a. 51 b.51.18 c.30 d.31 e.21 65. If a clinical study of a new drug demonstrated that the drug met the effectiveness criteria in 646 patients of the 942 patients enrolled in the study, express these results as a percent. a. 69% b. 0.68% c. 0.15% d. 15% ` e. 68.08% 66. NEUPOGEN prefilled syringes contain 480 mcg of active constituent in each 0.8mL. The equivalent concentration is: a. 0.62% b. 0.384% c. 0.06% d. 0.6% e. 0.006% 67. A lotion vehicle contains 15% (v/v) of glycerin. How much glycerin should be used in preparing 5 gallons of the lotion? a. 2271g b. 333.97g c.2671.8g d. 3548g e. 35.48g 68. LEVAQUIN (levofloxacin) injection contains 5mg/mL of levofloxacin and 5% dextrose. How much of each would be delivered to a patient upon the administration of a 100mL injection? a. 5g levofloxacin and 5g dextrose b. 50mg levofloxacin and 5g dextrose c. 500mg levofloxacin and 500mg dextrose d. 0.5g levofloxacin and 5g dextrose e. 500mg levofloxacin and 50g dextrose 69. For a 22-lb pediatric patient, the dose of Cefdinir (OMNICEF) was determined to be 7mg/kg. what quantity of an oral suspension containing 125mg of cefdinir in each 5mL should be administered? a. 2.8mL b. 5.6mL c. 8.9mL d. 13.6mL e. 70mL 70. A 142-lb patient was receiving filgrastim (NEUPOGEN) in doses of 10mcg/kg/day, as a result of successful blood test, dose was lowered to 6mcg/kg/day. Using an injection containing 0.3mg filgrastim per o.5mL, calculate the previous and new dose to be administered: a. 7.7mL and 64.6mL b 5.23mL and 3.14mL c. 1.08mL and 0.65mL d. 3.87mL and 2.3mL e. 3.14mL and 0.65mL 71. The dose of VOLTAREN (diclofenac sodium) GEL, when applied to the hands in the treatment of arthritic pain, is 2g four times a day. The gel contains diclofenac sodium 1% and is available in 100g- tubes. How many grams of the drug diclofenac sodium would be administered per day and how many days of treatment would be available per tube of gel? a. 8g diclofenac Na per day for 8 days b. 8g diclofenac Na per day for 12 ½ days c. 80mg diclofenac Na per day for 8 days d. 8mg diclofenac Na per day for 12 ½ days 72. A metronidazole vaginal gel contains 0.75% of drug in 70g tubes. An applicator will hold 5g of gel for each administration. How much drug will be contained in each application? a. 0.0375mg b. 3.75mg c. 37.5mg d. 375mg e. 0.375mg 73. How many g of an ointment base must be added to 45g of clobetasol (TEMOVATE) ointment, 0.05% w/w, to change its strength to 0.03% w/w? a. 30g b. 75g c. 45g d. 3g e. 40g 74. A child weighing 38kg is being treated for active tuberculosis with oral rifampin (RIFADIN). The recommended dose for this antitubercular drug is 1omg/kg. Which dose is considered safe for this child? a. 275 mg b. 300mg c.380mg d. 410.5mg e. 3.8mg 75. How many grams of pure drug are in 50mL of a 25% glucose solution? a. 3g b. 8.75g c. 12.5g d. 18g e. 1.25g 76. A patient with a BSA of 1.5m2 is to receive the antineoplastic drug mechlorethamine 6mg/m2 as a single IV dose. The vial is labeled 1mL=10mg. How many should be prepared? a. 0.25mL b. 0.45mL c. 0.9mL d. 1.8mL e. 0.09mL 77. Levodopa (larodopa) 2000mg P.O has been ordered. This antiparkinsonian agent is available in 500mg tablets. How many tablets should be administered? a. 2 tablets b. 4 tablets c. 6 tablets d. 18 tablets e. 9 tablets 78. You are transcribing the following prescription order to the medication order sheet: Zantac 150mg PO BID. What does the order mean? a. Administer Zantac 150mg by mouth twice a day b. Administer Zantac 150mg by mouth every other day c. Administer Zantac 75mg twice a day, for a total of 150mg in a 24-hr period d. Administer Zantac 75mg e. Administer Zantac 150mg 79. Jianella is 9 years old and weighs 67.5 lb. The prescribed dose for erythromycin stearate is 20mg/kg per dose QID. You have erythromycin stearate 200mg/5mL in stock. Calculate the number of teaspoons of erythromycin/dose for Jianella. a. 3 tsp/dose d. 4 tsp/dose b. 2.5 tsp/dose e. 2 tsp/dose c. 1 tsp/dose 80. Ancell, a 15 year-old boy, weigh 98 pounds and is to receive an initial insulin dose for hyperglycemia and ketonuria. The prescription reads, “regular insulin 0.1 U/kg SQ QID.” How many units of regular insulin will ancell receive at each dose? a. 98 U/dose b. 4.5 U/dose c. 45 U/dose d. 98 U/dose e. 4.4 U/dose 81. Julienn Cruz is to be placed on a hypothermia blanket when his temperature is equal to or, greater than 39°C. You have only a farenheit thermometer. At what degree Farenheit would you first place Julienn on the Hypothermia blanket? a. 71°F b. 39.5°F c. 102.2°F d. 127.8°F e. 128.7°F 82. You instruct a patient how to self administer eye drops that were prescribed to treat his ocular infection. You know the patient understands how to do this correctly when he says: a. “if my wife catches this infection, I’ll let her use my drops” b. “I wont touch any part of my eye when I put in drops c. “I’ll hold my eye open with my fingers and let the drop fall on my eyeball.” d. i’ll wipe my eyes from the side of my face to the side time. e. ” I need to touch my eye when I put the drops” 83. Dopamine is prescribed at 5mcg/kg/min. Solution is 250 ml d5w with 400 mg dopamine. Patient weight is 80 kg. What is the flow rate in mL/hr? a. 4ml/hr b.15mg/ml c.2400ml/hr d.80ml/hr e.240ml/hr 84. The prescription for a patient’s patient controlled analgesics (PCA) pump reads, “morphine sulfate 0.1 mg q 4 h”. What is the total dose of morphine allowed in a 24h period? a.24mg b.2.4mg c.2.8mg d.3mg e.3.8mg 85. If equal portion of tretinoin gel (RETIN- A MICRO), 0.1% w/w and 0.04 % w/w, are combined, what would be the resultant % strength? a.0.07% b.0.14% c.2% d.14.29% e.0.014% 86. If the tax on alcohol is P13.50 per proof gallon, how much tax must be paid on 5 gallons of alcohol, USP, which contains 94.9% v/v of pure alcohol? a. P120 b.P128.12 c.P240 d.121.82 e.P244 87. How many grams of potassium citrate (C6H5K3O7.H2O)-MWT=324) should be used in preparinf 500 ml of a potassium ion elixir so as to supply 15 meq of K+ in each 5 ml dose? a. 2g b.16.2g c.1.62g d.1620g e.0.162g 88. How many of anhydrous dextrose (E=0.18) should be used in preparing 1 liter of a ½ % isotonic ephedrine sulfate (E=0.23) nasal spray? a. 5g b.7.85g c.43.61g d.1.15g e.0.5g 89. Five pints of diluted HCl weighs 2.79kg. Calculate its specific gravity: a. 1.180 b.8.476 c. 1.21 d. 0.85 e. 0.60 90. A hospital worker combined 2-fluidounces of a povidone-iodine cleaner, 7.5% w/v. Calculate the resulting strength of the povidone-iodine mixture. a. 55% b. 9.17% c. 0.11% d. 0.92% e. 0.83% 91. 250mcg equal how many milligrams? a. 0.0025 b. 0.005 c. 0.05 d. 0.25 e. 0.025 92. How many fluidounces are in 3 pt? a. 9 b. 24 c. 48 d. 56 e. 12 93. The physician order scopolamine 1mg PO. This anticholinergic drug is available in capsules of. 0.25mg each. How many capsules should be given? a. 1 capsule b. 2 capsules c. 3 capsules d. 4 capsules e. 5 capsules 94. Nystatin oral suspension 600,000 U is ordered. The bottle is labeled 1mL=100,000 U. How many milliliters of this antifungal agent should be administered? a. 6mL d. 100mL b. 10mL e. 50mL 95. How many milligrams of an antacid would be included in a 10mL container labeled 50%? a. 50mg b. 150mg c. 500mg d. 5000mg e. 1500mg 96. The directions intended for the patient on a prescription read “1 tbsp ac and hs for 10 days.” What is the minimum volume the pharmacist should dispense? a. 160mL b. 200mL c. 400mL d. 600mL e. 800mL 97. The upper therapeutic drug concentration for vancomycin is considered to be 40mcg/mL. Express this value in terms of mg/dL. a. 0.04mg/dl b. 0.44mg/dl c. 4mg/dL d. 40mg/dL e. 400mg/dL 98. The child’s dose of a drug is reported as 1.2mg/kg body weight. What is the appropriate dose for child weighing 60 lb? a. 6mg b. 9mg c. 32mg d. 72mg e. 126mg 99. A package insert lists a drug dose for a neonate as being 10mcg/kg/day. The age range for a neonate is considered to be: a. Birth to 1 month b. 1 month to 6 months c. 1 month to 1 year d. Birth to 1 week e. 1 year through 5 years 100. Micro, nano, atto and meg are prefixes associated with which of the following measuring systems? I. Avoirdupois II. Metric III. System International a. I d. II and III only b. II e. I, II and III c. I and II only