Blood Bank ASCP EXAM
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1. What type of serological testing phenotyping
does the blood
bank technologist perform when
determining the
blood group of a patient?
2. If anti-K reacts 3+ with a donor Dosage
cell with a
genotype KK and 2+ with a Kk
cell, the antibody
is demonstrating:
3. Carla expresses the blood group Gender and Race. The frequency of
antigens Fya, Fyb, and Xga. Duffy antigens Fya and Fyb varies
James shows expressions of with race. The Fy(ab) phenotype occurs
none of these antigens. What in almost
factor(s) may account for the 70% of African Americans and is very
absence of these antigens in rare in whites.
James? The Xga antigen is X-linked and, there-
fore, expressed more frequently in
women (who may inherit the antigen
from either parent) than in men.
4. Which of the following state- B. An individual with the BB genotype is
ments is true? homozygous for B antigen
A. An individual with the BO
genotype is
homozygous for B antigen
B. An individual with the BB
genotype is
homozygous for B antigen
C. An individual with the OO
genotype is
heterozygous for O antigen
D. An individual with the AB phe-
notype is
homozygous for A and B anti-
gens
, Blood Bank ASCP EXAM
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5. Which genotype is heterozygous A. DCe/dce
for C?
A. DCe/dce
B. DCE/DCE
C. Dce/dce
D. DCE/dCe
6. Which genotype(s) will give rise The Bombay phenotype will be ex-
to the Bombay phenotype? pressed only when no H substance is
present. The Oh type is expressed by
the genotype hh. Bombays produce nat-
urally occurring anti-H, and their serum
agglutinates group
O red cells in addition to red cells from
groups A, B, and AB persons.
7. Meiosis in cell division is lim- 1N. Meiosis involves two nuclear divi-
ited to the ova and sperm pro- sions in succession resulting in four ga-
ducing four gametes containing metocytes each containing half the num-
what complement of DNA? ber of chromosomes found in somatic
cells or 1N.
8. A cell that is not actively dividing Interphase, The cell is engaged in meta-
is said to be in: bolic activity. Chromosomes are not
clearly discerned; however, nucleoli may
be
visible
9. Which of the following describes Codominant
the expression of most blood
group antigens?
10. What blood type is not possible All are possible
for an offspring of an AO and BO
mating?
11. The alleged father of a child in -Indirect/secondary/second order
a disputed case of paternity is An indirect/secondary/second order ex-
blood group AB. The mother is clusion occurs when a genetic marker is
absent in the child but should have been
, Blood Bank ASCP EXAM
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group O and the child is group O. transmitted by the alleged father. In this
What type of exclusion is this? case, either A or B should be present in
the child.
12. If the frequency of gene Y is 0.4 Linkage disequilibrium.
and the frequency of gene Z is Linkage disequilibrium is a phenomenon
0.5, one would expect that they in which alleles situated in close proxim-
should occur together 0.2 (20%) ity on a chromosome associate with one
of the time. In actuality, another more than would be expected
they are found together 32% of from individual allelic frequencies.
the time. This is an example of:
13. In this type of inheritance, the Autosomal Dominant
father carries the trait on his X
chromosome. He has no sons
with the trait because he passed
his Y chromosome to his sons;
however, all his daughters will
express the trait.
14. In the Hardy-Weinberg formula, In the Hardy-Weinberg formula p2 + 2pq
p2 represents: + q2, p2 and q2 represent homozy-
gous expressions and 2pq represents
heterozygous expression. This formula
is
used in population genetics to determine
the frequency of different alleles.
15. What is the Hardy-Weinberg for- p2 + 2pq + q2 = 1
mula?
16. Why do IgM antibodies, such as IgM antibodies are larger molecules and
those formed against the ABO have the ability to bind more antigen
antigens, have the ability to di-
rectly agglutinate red blood cells
(RBCs) and cause visible agglu-
tination?
17. Which of the following enhance- LISS.
ment mediums decreases the LISS contains a reduced concentration
, Blood Bank ASCP EXAM
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zeta potential, allowing antibody of NaCl (0.2%) and results in a reduction
and antigen to come closer to- in charged ions within the ionic cloud,
gether? decreasing the zeta potential and facil-
itating antigen and antibody interaction.
18. This type of antibody response Secondary.
is analogous to an anamnestic An anamnestic response is a secondary
antibody reaction. immune response in which memory lym-
phocytes respond rapidly to foreign anti-
gen in producing specific antibody. The
antibodies are IgG and are produced
at lower doses of antigen than in the
primary response.
19. Which antibodies to a compo- In the DAT (direct antiglobulin test), rab-
nent of complement are con- bit
tained in the rabbit polyspecific polyspecific antisera contains both an
antihuman globulin reagent for anti-human IgG component and an an-
detection of in vivo sensitiza- tibody against the C3d component of
tion? complement.
20. Which of the following dis- B. An A2 person may form anti-A1; an A1
tinguishes A1 from A2 blood person will not form anti-A1
groups?
A. A2 antigen will not react with
anti-A, A1 will
react strongly (4+)
B. An A2 person may form
anti-A1; an A1 person
will not form anti-A1
C. An A1 person may form
anti-A2, an A2 person
will not form anti-A1
D. A2 antigen will not react
with anti-A from a nonimmunized
donor; A1 will react with any
anti-A
21. A patient's serum is incompati- Bombay is the only ABO phenotype in-
ble with O cells. The patient RBCs compatible with O cells. The red cells of
Study online at https://quizlet.com/_ee42f6
1. What type of serological testing phenotyping
does the blood
bank technologist perform when
determining the
blood group of a patient?
2. If anti-K reacts 3+ with a donor Dosage
cell with a
genotype KK and 2+ with a Kk
cell, the antibody
is demonstrating:
3. Carla expresses the blood group Gender and Race. The frequency of
antigens Fya, Fyb, and Xga. Duffy antigens Fya and Fyb varies
James shows expressions of with race. The Fy(ab) phenotype occurs
none of these antigens. What in almost
factor(s) may account for the 70% of African Americans and is very
absence of these antigens in rare in whites.
James? The Xga antigen is X-linked and, there-
fore, expressed more frequently in
women (who may inherit the antigen
from either parent) than in men.
4. Which of the following state- B. An individual with the BB genotype is
ments is true? homozygous for B antigen
A. An individual with the BO
genotype is
homozygous for B antigen
B. An individual with the BB
genotype is
homozygous for B antigen
C. An individual with the OO
genotype is
heterozygous for O antigen
D. An individual with the AB phe-
notype is
homozygous for A and B anti-
gens
, Blood Bank ASCP EXAM
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5. Which genotype is heterozygous A. DCe/dce
for C?
A. DCe/dce
B. DCE/DCE
C. Dce/dce
D. DCE/dCe
6. Which genotype(s) will give rise The Bombay phenotype will be ex-
to the Bombay phenotype? pressed only when no H substance is
present. The Oh type is expressed by
the genotype hh. Bombays produce nat-
urally occurring anti-H, and their serum
agglutinates group
O red cells in addition to red cells from
groups A, B, and AB persons.
7. Meiosis in cell division is lim- 1N. Meiosis involves two nuclear divi-
ited to the ova and sperm pro- sions in succession resulting in four ga-
ducing four gametes containing metocytes each containing half the num-
what complement of DNA? ber of chromosomes found in somatic
cells or 1N.
8. A cell that is not actively dividing Interphase, The cell is engaged in meta-
is said to be in: bolic activity. Chromosomes are not
clearly discerned; however, nucleoli may
be
visible
9. Which of the following describes Codominant
the expression of most blood
group antigens?
10. What blood type is not possible All are possible
for an offspring of an AO and BO
mating?
11. The alleged father of a child in -Indirect/secondary/second order
a disputed case of paternity is An indirect/secondary/second order ex-
blood group AB. The mother is clusion occurs when a genetic marker is
absent in the child but should have been
, Blood Bank ASCP EXAM
Study online at https://quizlet.com/_ee42f6
group O and the child is group O. transmitted by the alleged father. In this
What type of exclusion is this? case, either A or B should be present in
the child.
12. If the frequency of gene Y is 0.4 Linkage disequilibrium.
and the frequency of gene Z is Linkage disequilibrium is a phenomenon
0.5, one would expect that they in which alleles situated in close proxim-
should occur together 0.2 (20%) ity on a chromosome associate with one
of the time. In actuality, another more than would be expected
they are found together 32% of from individual allelic frequencies.
the time. This is an example of:
13. In this type of inheritance, the Autosomal Dominant
father carries the trait on his X
chromosome. He has no sons
with the trait because he passed
his Y chromosome to his sons;
however, all his daughters will
express the trait.
14. In the Hardy-Weinberg formula, In the Hardy-Weinberg formula p2 + 2pq
p2 represents: + q2, p2 and q2 represent homozy-
gous expressions and 2pq represents
heterozygous expression. This formula
is
used in population genetics to determine
the frequency of different alleles.
15. What is the Hardy-Weinberg for- p2 + 2pq + q2 = 1
mula?
16. Why do IgM antibodies, such as IgM antibodies are larger molecules and
those formed against the ABO have the ability to bind more antigen
antigens, have the ability to di-
rectly agglutinate red blood cells
(RBCs) and cause visible agglu-
tination?
17. Which of the following enhance- LISS.
ment mediums decreases the LISS contains a reduced concentration
, Blood Bank ASCP EXAM
Study online at https://quizlet.com/_ee42f6
zeta potential, allowing antibody of NaCl (0.2%) and results in a reduction
and antigen to come closer to- in charged ions within the ionic cloud,
gether? decreasing the zeta potential and facil-
itating antigen and antibody interaction.
18. This type of antibody response Secondary.
is analogous to an anamnestic An anamnestic response is a secondary
antibody reaction. immune response in which memory lym-
phocytes respond rapidly to foreign anti-
gen in producing specific antibody. The
antibodies are IgG and are produced
at lower doses of antigen than in the
primary response.
19. Which antibodies to a compo- In the DAT (direct antiglobulin test), rab-
nent of complement are con- bit
tained in the rabbit polyspecific polyspecific antisera contains both an
antihuman globulin reagent for anti-human IgG component and an an-
detection of in vivo sensitiza- tibody against the C3d component of
tion? complement.
20. Which of the following dis- B. An A2 person may form anti-A1; an A1
tinguishes A1 from A2 blood person will not form anti-A1
groups?
A. A2 antigen will not react with
anti-A, A1 will
react strongly (4+)
B. An A2 person may form
anti-A1; an A1 person
will not form anti-A1
C. An A1 person may form
anti-A2, an A2 person
will not form anti-A1
D. A2 antigen will not react
with anti-A from a nonimmunized
donor; A1 will react with any
anti-A
21. A patient's serum is incompati- Bombay is the only ABO phenotype in-
ble with O cells. The patient RBCs compatible with O cells. The red cells of
