1|Page
# NSG 6001 MIDTERM EXAM 2## ADVANCED
NURSING PRACTICE | COMPLETE TEST PREP BANK
(200+ QUESTIONS)### HIGH-YIELD CONTENT |
GRADED A+ | FIRST TIME PASS
## Table of Contents
1. **Advanced Pharmacology** (35 questions)
2. **Advanced Pathophysiology** (30 questions)
3. **Advanced Health Assessment** (25 questions)
4. **Evidence-Based Practice & Research** (20 questions)
5. **Professional Role & Leadership** (20 questions)
6. **Healthcare Policy & Ethics** (15 questions)
7. **Population Health & Epidemiology** (15 questions)
8. **Diagnostic Reasoning & Clinical Decision-Making** (20 questions)
9. **Interprofessional Collaboration & Communication** (10 questions)
10. **Quality Improvement & Patient Safety** (10 questions)
11. **Final Comprehensive Review** (20 questions)
---
,2|Page
## Section 1: Advanced Pharmacology (35 Questions)
**1.** A patient with heart failure with reduced ejection fraction (HFrEF) is
prescribed sacubitril/valsartan (Entresto). The mechanism of action is:
A. Neprilysin inhibition (increases natriuretic peptides) combined with angiotensin
receptor blockade
B. Beta-1 receptor blockade
C. Aldosterone antagonism
D. Direct vasodilation
**Correct Answer: A**
*Rationale:* Sacubitril/valsartan (ARNI) is superior to ACE inhibitors in reducing
HFrEF mortality. It is contraindicated with ACE inhibitors (risk of angioedema,
washout period required).
---
**2.** A patient with type 2 diabetes and established cardiovascular disease is
prescribed a GLP-1 receptor agonist (liraglutide, semaglutide). Benefits include:
A. Cardiovascular risk reduction (MACE), weight loss, and glycemic control
B. Increased risk of heart failure
C. Weight gain
D. Increased hypoglycemia
**Correct Answer: A**
,3|Page
*Rationale:* GLP-1 receptor agonists (liraglutide, semaglutide, dulaglutide) reduce
major adverse cardiovascular events (MACE). They also promote weight loss.
---
**3.** A patient is prescribed warfarin for atrial fibrillation. Which medication
interaction would most increase the INR and bleeding risk?
A. Trimethoprim-sulfamethoxazole (TMP-SMX) – inhibits warfarin metabolism
B. Oral contraceptives
C. Rifampin (decreases INR)
D. Vitamin K (decreases INR)
**Correct Answer: A**
*Rationale:* Many antibiotics (metronidazole, TMP-SMX, fluconazole) potentiate
warfarin. Monitor INR frequently.
---
**4.** A patient with a seizure disorder is prescribed phenytoin (Dilantin). The
therapeutic serum level is:
A. 10-20 mcg/mL
B. 5-10 mcg/mL
C. 20-30 mcg/mL
, 4|Page
D. 1-5 mcg/mL
**Correct Answer: A**
*Rationale:* Phenytoin has a narrow therapeutic window. Levels >20 mcg/mL
cause toxicity (nystagmus, ataxia, confusion, sedation).
---
**5.** A patient with bipolar disorder is prescribed lithium. Which baseline
laboratory tests are required?
A. Renal function (BUN, creatinine), thyroid function (TSH), electrolytes, and
pregnancy test (if applicable)
B. Only lithium level
C. Only CBC
D. Only liver function
**Correct Answer: A**
*Rationale:* Lithium toxicity risk is increased by dehydration, renal impairment,
and drug interactions (NSAIDs, ACE inhibitors, thiazide diuretics).
---
# NSG 6001 MIDTERM EXAM 2## ADVANCED
NURSING PRACTICE | COMPLETE TEST PREP BANK
(200+ QUESTIONS)### HIGH-YIELD CONTENT |
GRADED A+ | FIRST TIME PASS
## Table of Contents
1. **Advanced Pharmacology** (35 questions)
2. **Advanced Pathophysiology** (30 questions)
3. **Advanced Health Assessment** (25 questions)
4. **Evidence-Based Practice & Research** (20 questions)
5. **Professional Role & Leadership** (20 questions)
6. **Healthcare Policy & Ethics** (15 questions)
7. **Population Health & Epidemiology** (15 questions)
8. **Diagnostic Reasoning & Clinical Decision-Making** (20 questions)
9. **Interprofessional Collaboration & Communication** (10 questions)
10. **Quality Improvement & Patient Safety** (10 questions)
11. **Final Comprehensive Review** (20 questions)
---
,2|Page
## Section 1: Advanced Pharmacology (35 Questions)
**1.** A patient with heart failure with reduced ejection fraction (HFrEF) is
prescribed sacubitril/valsartan (Entresto). The mechanism of action is:
A. Neprilysin inhibition (increases natriuretic peptides) combined with angiotensin
receptor blockade
B. Beta-1 receptor blockade
C. Aldosterone antagonism
D. Direct vasodilation
**Correct Answer: A**
*Rationale:* Sacubitril/valsartan (ARNI) is superior to ACE inhibitors in reducing
HFrEF mortality. It is contraindicated with ACE inhibitors (risk of angioedema,
washout period required).
---
**2.** A patient with type 2 diabetes and established cardiovascular disease is
prescribed a GLP-1 receptor agonist (liraglutide, semaglutide). Benefits include:
A. Cardiovascular risk reduction (MACE), weight loss, and glycemic control
B. Increased risk of heart failure
C. Weight gain
D. Increased hypoglycemia
**Correct Answer: A**
,3|Page
*Rationale:* GLP-1 receptor agonists (liraglutide, semaglutide, dulaglutide) reduce
major adverse cardiovascular events (MACE). They also promote weight loss.
---
**3.** A patient is prescribed warfarin for atrial fibrillation. Which medication
interaction would most increase the INR and bleeding risk?
A. Trimethoprim-sulfamethoxazole (TMP-SMX) – inhibits warfarin metabolism
B. Oral contraceptives
C. Rifampin (decreases INR)
D. Vitamin K (decreases INR)
**Correct Answer: A**
*Rationale:* Many antibiotics (metronidazole, TMP-SMX, fluconazole) potentiate
warfarin. Monitor INR frequently.
---
**4.** A patient with a seizure disorder is prescribed phenytoin (Dilantin). The
therapeutic serum level is:
A. 10-20 mcg/mL
B. 5-10 mcg/mL
C. 20-30 mcg/mL
, 4|Page
D. 1-5 mcg/mL
**Correct Answer: A**
*Rationale:* Phenytoin has a narrow therapeutic window. Levels >20 mcg/mL
cause toxicity (nystagmus, ataxia, confusion, sedation).
---
**5.** A patient with bipolar disorder is prescribed lithium. Which baseline
laboratory tests are required?
A. Renal function (BUN, creatinine), thyroid function (TSH), electrolytes, and
pregnancy test (if applicable)
B. Only lithium level
C. Only CBC
D. Only liver function
**Correct Answer: A**
*Rationale:* Lithium toxicity risk is increased by dehydration, renal impairment,
and drug interactions (NSAIDs, ACE inhibitors, thiazide diuretics).
---
