ADME PHARMACOKINETICS EXAM QUESTIONS
COMPLETE WITH 100% VERIFIED ANSWERS
1. What does the letter 'D' in ADME stand for in pharmacokinetics?
A. Detoxification
B. Dissolution
C. Degradation
D. Distribution
2. Drug movement from the blood to the interstitial space of tissues
and from there into cells:
A. biotransformation
B. absorption
C. distribution
D. protein binding
3. If a patient requires rapid pain relief, which method of drug
administration would be most appropriate and why?
A. Swallowing, because it is more convenient.
B. Injection, because it provides immediate access to the
bloodstream and faster onset of action.
C. Swallowing, because it is safer.
D. Injection, because it is less expensive.
,4. Describe how zero order kinetics can lead to an increased risk of
overdose.
A. In zero order kinetics, the constant rate of drug excretion
means that even with increased dosage, the body cannot
eliminate the drug faster, leading to accumulation.
B. Zero order kinetics means that drugs are absorbed more
efficiently.
C. Drugs with zero order kinetics are always eliminated completely
from the body.
D. Zero order kinetics allows for faster metabolism of drugs,
reducing overdose risk.
5. Describe the sequence of organs a drug passes through after
absorption in the gut until it reaches the arteries.
A. The drug is absorbed in the gut and directly enters the arteries
without passing through any other organs.
B. The drug is absorbed in the gut, travels to the stomach, then to
the intestines, and finally to the arteries.
C. After absorption in the gut, the drug passes through the liver,
then into the veins, to the right side of the heart, to the lungs,
back to the left side of the heart, and finally into the arteries.
D. The drug is absorbed in the gut and goes straight to the heart.
6. A patient takes a medication with a half-life of 6 hours. If the initial
dose is 100 mg, how much of the drug will remain in the body
after 18 hours?
A. 12.5 mg
B. 75 mg
, C. 50 mg
D. 25 mg
7. Describe the roles of the kidneys and liver in the excretion of
drugs from the body.
A. The kidneys and liver both produce hormones that regulate
drug levels in the body.
B. The kidneys absorb drugs back into the bloodstream, while the
liver metabolizes them into glucose.
C. The kidneys filter blood to produce urine, which excretes
drugs, while the liver produces bile that can carry drugs to be
excreted in feces.
D. The kidneys detoxify drugs, while the liver stores them for later
use.
8. Distribution takes the drug molecules from the _____ to the
_____ .
A. site of administration; bloodstream
B. tissues; bloodstream
C. bloodstream; tissues
D. bloodstream; site of administration
9. Which drug has more chances of cumulation?
A. Same
B. First order kinetics
C. Zero order kinetics
D. (Option missing in original)
10. Which of the following describes the correct pathway of
orally administered drugs in the body once swallowed?
A. GI tract → Stomach → Upper intestine → Cells lining the gut
COMPLETE WITH 100% VERIFIED ANSWERS
1. What does the letter 'D' in ADME stand for in pharmacokinetics?
A. Detoxification
B. Dissolution
C. Degradation
D. Distribution
2. Drug movement from the blood to the interstitial space of tissues
and from there into cells:
A. biotransformation
B. absorption
C. distribution
D. protein binding
3. If a patient requires rapid pain relief, which method of drug
administration would be most appropriate and why?
A. Swallowing, because it is more convenient.
B. Injection, because it provides immediate access to the
bloodstream and faster onset of action.
C. Swallowing, because it is safer.
D. Injection, because it is less expensive.
,4. Describe how zero order kinetics can lead to an increased risk of
overdose.
A. In zero order kinetics, the constant rate of drug excretion
means that even with increased dosage, the body cannot
eliminate the drug faster, leading to accumulation.
B. Zero order kinetics means that drugs are absorbed more
efficiently.
C. Drugs with zero order kinetics are always eliminated completely
from the body.
D. Zero order kinetics allows for faster metabolism of drugs,
reducing overdose risk.
5. Describe the sequence of organs a drug passes through after
absorption in the gut until it reaches the arteries.
A. The drug is absorbed in the gut and directly enters the arteries
without passing through any other organs.
B. The drug is absorbed in the gut, travels to the stomach, then to
the intestines, and finally to the arteries.
C. After absorption in the gut, the drug passes through the liver,
then into the veins, to the right side of the heart, to the lungs,
back to the left side of the heart, and finally into the arteries.
D. The drug is absorbed in the gut and goes straight to the heart.
6. A patient takes a medication with a half-life of 6 hours. If the initial
dose is 100 mg, how much of the drug will remain in the body
after 18 hours?
A. 12.5 mg
B. 75 mg
, C. 50 mg
D. 25 mg
7. Describe the roles of the kidneys and liver in the excretion of
drugs from the body.
A. The kidneys and liver both produce hormones that regulate
drug levels in the body.
B. The kidneys absorb drugs back into the bloodstream, while the
liver metabolizes them into glucose.
C. The kidneys filter blood to produce urine, which excretes
drugs, while the liver produces bile that can carry drugs to be
excreted in feces.
D. The kidneys detoxify drugs, while the liver stores them for later
use.
8. Distribution takes the drug molecules from the _____ to the
_____ .
A. site of administration; bloodstream
B. tissues; bloodstream
C. bloodstream; tissues
D. bloodstream; site of administration
9. Which drug has more chances of cumulation?
A. Same
B. First order kinetics
C. Zero order kinetics
D. (Option missing in original)
10. Which of the following describes the correct pathway of
orally administered drugs in the body once swallowed?
A. GI tract → Stomach → Upper intestine → Cells lining the gut
