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acute resp distress syndrome (ards) Correct Answers Sudden
progressive form of acute respiratory failure
Alveolar capillary interface becomes damaged and more permeable to
intravascular fluid (alveoli fill with fluid)
co2 from ___ to _____ Correct Answers pulm cap to alveolus
o2 from ___ to _____ Correct Answers alveolus to pulm vein`
Interstitial edema occurs with
(in ards) Correct Answers increased flow of fluid into the interstitial
space.
intersistial space between pulm capillary and alveolus
Alveolar edema occurs when
(in ards) Correct Answers fluid crosses the blood-gas barrier.
,results of ards Correct Answers Severe dyspnea
Hypoxia
Decreased lung compliance
Diffuse pulmonary infiltrates (150,000 cases annually; 50% mortality
rate)
(Patients who have both gram-negative septic shock and ARDS have a
mortality rate of 70% to 90%. )
Etiology and Pathophysiology of ards Correct Answers Develops from a
variety of direct or indirect lung injuries
(Most common cause is sepsis)
Exact cause for damage to alveolar-capillary membrane not known
Pathophysiologic changes of ARDS thought to be due to stimulation of
inflammatory and immune systems
pathophys map Correct Answers see slide 12
why may ards develop (3) Correct Answers Direct lung injury may
cause ARDS,
or ARDS may develop because of the systemic inflammatory response
syndrome (SIRS).
, ARDS may also develop as a consequence of multiple organ
dysfunction syndrome (MODS).
Neutrophils are attracted and release mediators, producing changes in
lungs Correct Answers ↑ Pulmonary capillary membrane permeability
Destruction of elastin and collagen
Formation of pulmonary microemboli
Pulmonary artery vasoconstriction
The pathophysiologic changes in ARDS are divided into three phases:
Correct Answers 1) injury or exudative phase,
(2) reparative or proliferative phase, and
(3) fibrotic phase.
Injury or exudative phase (hours/days) Correct Answers -usually occurs
24 to 48 hours after the initial direct lung injury.
-1-7 days after direct lung injury or host insult
-Neutrophils adhere to pulmonary microcirculation (Damage to vascular
endothelium; ↑ Capillary permeability)
-Engorgement of peribronchial and perivascular interstitial space
-Fluid crosses into alveolar space
-Intrapulmonary shunt develops as alveoli fill with fluid, and blood
passing through cannot be oxygenated
Injury or exudative phase