MCCANCE PATHOPHYSIOLOGY THE
BIOLOGIC BASIS FOR DISEASE IN ADULTS AND
CHILDREN 8TH EDITION 2026
COMPREHENSIVE NOTES AND WORKBOOK A+
◉ Health. Answer: State of complete physical, mental, and social
well-being and not merely the absence of disease and infirmity.
◉ Disease. Answer: An acute or chronic illness that one acquires or
is born with that causes physiological dysfunction in one or more
body system.
◉ Etiology. Answer: Causes of disease, including biological agents,
physical forces, chemical agents, one's genetic inheritance, and
nutritional excesses or deficits.
◉ Congenital conditions. Answer: Defects that are present at birth,
although they may not be evident until later in life or may never
manifest.
◉ Pathogenesis. Answer: The sequence of cellular and tissue events
that take place from the time of initial contact with an etiologic
agent until the ultimate expression of a disease. (explains how the
disease process evolves)
, ◉ Morphology. Answer: The fundamental structure or form of cells
and tissues.
◉ Histology. Answer: The study of the cells and extracellular matrix
of body tissues.
◉ Lesion. Answer: A pathologic or traumatic discontinuity of a body
organ or tissue.
◉ Signs and symptoms. Answer: The structural and functional
changes that accompany a disease.
◉ Symptom. Answer: A subjective complaint noted by the person
with a disorder.
◉ Sign. Answer: A manifestation of disorder that is noted by an
observer.
◉ Syndrome. Answer: A compilation of signs and symptoms
characteristic of a specific disease state.
◉ Complications. Answer: Possible adverse extensions of a disease
or outcomes from treatment.
BIOLOGIC BASIS FOR DISEASE IN ADULTS AND
CHILDREN 8TH EDITION 2026
COMPREHENSIVE NOTES AND WORKBOOK A+
◉ Health. Answer: State of complete physical, mental, and social
well-being and not merely the absence of disease and infirmity.
◉ Disease. Answer: An acute or chronic illness that one acquires or
is born with that causes physiological dysfunction in one or more
body system.
◉ Etiology. Answer: Causes of disease, including biological agents,
physical forces, chemical agents, one's genetic inheritance, and
nutritional excesses or deficits.
◉ Congenital conditions. Answer: Defects that are present at birth,
although they may not be evident until later in life or may never
manifest.
◉ Pathogenesis. Answer: The sequence of cellular and tissue events
that take place from the time of initial contact with an etiologic
agent until the ultimate expression of a disease. (explains how the
disease process evolves)
, ◉ Morphology. Answer: The fundamental structure or form of cells
and tissues.
◉ Histology. Answer: The study of the cells and extracellular matrix
of body tissues.
◉ Lesion. Answer: A pathologic or traumatic discontinuity of a body
organ or tissue.
◉ Signs and symptoms. Answer: The structural and functional
changes that accompany a disease.
◉ Symptom. Answer: A subjective complaint noted by the person
with a disorder.
◉ Sign. Answer: A manifestation of disorder that is noted by an
observer.
◉ Syndrome. Answer: A compilation of signs and symptoms
characteristic of a specific disease state.
◉ Complications. Answer: Possible adverse extensions of a disease
or outcomes from treatment.
