NR 565||(NR 565 ) Final Exam/ MIDTERM EXAM Questions
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What labs are used to diagnose Thyroid? - TSH, total T4 and T3, free T4 and T3
Timeframe for re-check of labs after starting levothyroxine - 6-8 wks after starting therapy
Signs and symptoms of hypothyroidism - Face: Pale, puffy, expressionless
Skin: Cold and dry
Hair: Brittle and hair loss
Heart rate and temp are lowered
Complaints by patient: lethargy, fatigue, intolerance to cold
Mentation may be impaired
Thyroid enlargement if ↓'d levels of T3 and T4 promoting excessive release of TSH
Treatment of thyroid storm - High dose potassium iodide or strong iodine solution to suppress thyroid
hormone release,
methimazole to suppress thyroid hormone synthesis,
beta blocker to reduce heart rate, sedation cooling glucocorticoids and IV fluids
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Result of not treating hypothyroidism during pregnancy - permanent neurological defects, ↓'d IQ, large
protruding tongue, potbelly dwarfish stature, impaired development of nervous system bone teeth and
muscles.
Medication to treat symptoms of hyperthyroidism (notice this is treating symptoms and not the
hyperthyroidism itself) - Metoprolol could be used to treat tachycardia experienced with
hyperthyroidism, but it does not treat hyperthyroidism itself.
Drug/Food/Supplement interactions with levothyroxine Absorption REDUCED by: - Histamine 2 receptor
blockers (Cimetidine [Tagamet])
Proton pump inhibitors (Lansoprazole)
Sucralfate (Carafate)
Cholestyramine (Questran)
Colestipol (Colestid)
Aluminum containing antacids (maalox, mylanta)
Calcium supplements (tums, os-cal)
Iron supplements
Magnesium salts
Orlistat (Xenical)
* 4 hours between levothyroxine and the above meds is recommended and food reduces absorption as
well
How to confirm a diagnosis of DM prior to beginning treatment - Hemoglobin A1C > 6.5%,
Fasting plasma glucose ≧126 mg/dL, Random plasma glucose ≧200 mg/dL plus symptoms of diabetes,
Oral glucose tolerance test (OGTT):
2-h plasma glucose ≧200 mg/dL
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