SHEET 2026 QUESTIONS AND VERIFIED
SOLUTIONS GUARANTEED TO PASS
◉ Lipid accumulation. Answer: Steatosis (fatty change)
- In liver and appears as clear vacuoles in cytoplasm.
◉ Cholesterol and cholesterol esters accumulate in _____. _____. and
_____ and will form foam cells in the arterial walls.. Answer: 1.
Atherosclerosis
2. Xanthomas
3. Xanthelasma
◉ Protein accumulation is associated with _____ change.. Answer:
Hyaline change.
-Eosinophilic glassy appearance with cellular and extracellular
aggregation/deposition.
◉ Protein accumulation: Russell bodies. Answer: Affects plasma cells
(Mott cells) and found in multiple myeloma.
◉ Protein accumulation: Mallory-Denk Bodies. Answer: Found in
hepatocytes and appears ropy eosinophilic cytoplasmic inclusions.
, ◉ Protein accumulation: neurodegenerative protein aggregates. _______
is found in a-synuclein in parkinson's disease.. Answer: Lewy bodies
◉ Protein accumulation: neurodegenerative protein aggregates. ______
is found in Tau in Alzheimer's disease.. Answer: Neurofibrillary tangles
◉ Protein accumulation: neurodegenerative protein aggregates. ______
is found in Huntington's disease.. Answer: Huntington protein
◉ Glycogen accumulation- Type I = ____________ and has a glucose-
6-phosphatase deficiency.. Answer: Von Gierke's
◉ Glycogen accumulation- Type II= _________ and has acid maltase
deficiency.. Answer: Pompe's
◉ Pigment accumulation:
1. Carbon (anthracosis in lungs). Answer: Black matter in lung
macrophages from air pollution, smoking, and coal miners.
◉ Pigment accumulation:
2. Tattoo pigments. Answer: Persist in dermal macrophages forever.
◉ Pigment accumulation:
3. Heavy metals (lead and silver). Answer: Lead- basophilic stippling in
RBC's lead lines in bone.