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Type II pneumocytes - ANSWER surfactant (*lecithin*)
Proliferate after injury
Type I progenitors
*Neonatal Respiratory Distress Syndrome*
Polio live v killed vaccine - ANSWER Killed = Salk = IgG
Live = Sabin = IgG + IgA
- can be shed in feces
Neonatal Respiratory Distress:
Etiology + Tx - ANSWER Maternal DM (*high insulin*)
or C-section (*low cortisol*)
TX: *dexamethasone* before birth
Lung maturity determined with - ANSWER Amniocentesis of Phospholipids
(*type II pneumocytes)
L >> S
,Type I pneumocytes - ANSWER Squamous gas diffusion
Elastase in lungs - ANSWER macrophage: *lysosomes*
PMN: *azuronphilic granules*
Elastin stretches and recoils due to - ANSWER Lysine interchain crosslinks
air pressure and
intrapleural pressure at FRC - ANSWER Air pressure = 0
Intrapleural pressure = -5
Commonly caused by thyroidectomy - ANSWER *Hypoparathyroid *
low PTH
low Ca/PO4 from bone
Low Ca reabs, Low PO4 excretion
Treat hypoparathyroid - ANSWER calcitriol
HyperCa of Malignancy - ANSWER *PTHrP*
high Ca (*from bone, not excreted)
bone metastases (bone, MM)
*1,25 dihydroxyvitamin D*
DiGeorge - ANSWER *22q11.2 microdeletion* (dx w FISH)
no thymic shadow (*3rd pharyngeal pouch*)
,paracotex (*T*) underdeveloped
CL/P and Tetralogy of Fallot
1* Hyperparathyroid levels - ANSWER high PTH
high Ca
low PO4
high Ca = stones thrones groans psych overtones
Osteitis Fibrosa Cystica - ANSWER subperiosteal resorption
(*fingers*)
brown tumor
Complication of Hyperparathyroid
What type of receptor requires Zinc to bind DNA sequence - ANSWER Thyroid
hormone
Steroid
Fat sol vitamins
Zinc deficiency - ANSWER erythematous; vesicular
impaired taste, smell, vision
Hyperthyroid levels - ANSWER high *T4*
low TSH
, Graves disease - ANSWER Anti Thyrotropin R
Proptosis + pretibial myxedema
tx Graves Opthalmopathy - ANSWER corticosteroids (Anti-inflammatory)
AE of anti-thyroid drugs - ANSWER agranulocytosis
--> sore throat
--> sepsis
Methimaxole - ANSWER inhibit thyroid peroxidase
(iodotyrosine coupling)
AE: agranulocytosis
Propylthiouracil - ANSWER inhibit* thyroid peroxidase*
- (iodotyrosine coupling)
Inhibit *T4 --> T3 *
AE: agranulocytosis
Inhibit T4 --> T3 conversion - ANSWER Propranolol, PTU, Ipodate
cellular process for TRH --> TSH - ANSWER IP3
Cellular process for TSH --> T3/T4 - ANSWER cAMP