NR565 MIDTERM, WEEK 4 QUESTIONS WITH ACCURATE
ANSWERS
2 drugs that require tapering when discontinuing in relation to HTN tx correct
answer beta blockers and clonidine
2 medications prescribed together that are highly protein bound, what is clinical
outcome? correct answer The two drugs compete for availability of plasma
proteins and one or the other becomes increasingly effective, think extra
medication is floating around as it cannot bind to plasma proteins. Warfarin is
highly protein bound.
4 phases of clinical trials correct answer I. small number of healthy volunteers
(dosage range), II. small group of patients (efficacy), III. large number of patients
(rare complications), various sites, IV. Post marketing surveillance
ACEIs correct answer monitor CMP or BMP for potassium retention and kidney
function
Pregnancy category C in first trimester, D in following
ADRs associated with betablockers correct answer Hypotension, bradycardia,
CHF, bronchospasm, dyspnea, fatigue, weakness, dizziness, anxiety, depression,
insomnia, drowsiness, anorexia, n/v, constipation, impotence, decreased libido,
myalgias, skin rashes, facial edema, instability in bgc
Alternatives to clopidogrel correct answer Brilinta (ticagrelor) or Effient
(Prasugrel) because they are not dependent on CYP2C19 genotype
, Antagonist correct answer Takes over receptor without stimulating that receptor.
Blocks receptors.
anticonvulsants rx to women of childbearing age correct answer lamotrigine has
lowest risk
Barrier in understanding racial differences in drug pharmacokinetics with
American Indian or Alaskan Natives? correct answer Limited to no research in
racial considerations
Beta 2 receptors correct answer smooth muscle of venules, bronchioles, liver, GU,
GI, eyes, pancreas.
increase cAMP, adenylyl cyclase, and cardiac G1.
Relax far vision, dilate arterioles of skeletal muscle, dilate pulm arterioles,
systemic veins, relax bronchial muscle, increase secretion of bronchial glands,
decrease GI motility, gluconeogenesis in the liver, increased secretion of insulin
from the pancreas, relaxation of the urinary bladder, and smooth muscle
relaxation in the uterus
Beta blockers that require dosage adjustment in patients with renal impairment
correct answer acebutolol, atenolol, nadolol, and nebivolol
Bioavailability correct answer the extent of a substance or drug that becomes
available to its intended biological destination.
Clinical significance of being an ultra rapid CYP2D6 metabolizer correct answer
break down meds rapidly, consider dose, response and toxicity in relation to beta
blockers, antidepressants, antiarrhythmics, and opioids.
ANSWERS
2 drugs that require tapering when discontinuing in relation to HTN tx correct
answer beta blockers and clonidine
2 medications prescribed together that are highly protein bound, what is clinical
outcome? correct answer The two drugs compete for availability of plasma
proteins and one or the other becomes increasingly effective, think extra
medication is floating around as it cannot bind to plasma proteins. Warfarin is
highly protein bound.
4 phases of clinical trials correct answer I. small number of healthy volunteers
(dosage range), II. small group of patients (efficacy), III. large number of patients
(rare complications), various sites, IV. Post marketing surveillance
ACEIs correct answer monitor CMP or BMP for potassium retention and kidney
function
Pregnancy category C in first trimester, D in following
ADRs associated with betablockers correct answer Hypotension, bradycardia,
CHF, bronchospasm, dyspnea, fatigue, weakness, dizziness, anxiety, depression,
insomnia, drowsiness, anorexia, n/v, constipation, impotence, decreased libido,
myalgias, skin rashes, facial edema, instability in bgc
Alternatives to clopidogrel correct answer Brilinta (ticagrelor) or Effient
(Prasugrel) because they are not dependent on CYP2C19 genotype
, Antagonist correct answer Takes over receptor without stimulating that receptor.
Blocks receptors.
anticonvulsants rx to women of childbearing age correct answer lamotrigine has
lowest risk
Barrier in understanding racial differences in drug pharmacokinetics with
American Indian or Alaskan Natives? correct answer Limited to no research in
racial considerations
Beta 2 receptors correct answer smooth muscle of venules, bronchioles, liver, GU,
GI, eyes, pancreas.
increase cAMP, adenylyl cyclase, and cardiac G1.
Relax far vision, dilate arterioles of skeletal muscle, dilate pulm arterioles,
systemic veins, relax bronchial muscle, increase secretion of bronchial glands,
decrease GI motility, gluconeogenesis in the liver, increased secretion of insulin
from the pancreas, relaxation of the urinary bladder, and smooth muscle
relaxation in the uterus
Beta blockers that require dosage adjustment in patients with renal impairment
correct answer acebutolol, atenolol, nadolol, and nebivolol
Bioavailability correct answer the extent of a substance or drug that becomes
available to its intended biological destination.
Clinical significance of being an ultra rapid CYP2D6 metabolizer correct answer
break down meds rapidly, consider dose, response and toxicity in relation to beta
blockers, antidepressants, antiarrhythmics, and opioids.
