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Actual HESI A2 Practice Test
Questions | Full Multi-Section
Diagnostic Mock Exam 2026
NAME: DATE:
Secure your competitive nursing school admission by acing the HESI A2 entrance exam on your very first try
with this exhaustive, multi-subject practice test package. Mapped meticulously to the official 2026 Elsevier
testing specifications, this high-converting marketplace resource delivers an elite collection of realistic mock
questions featuring verified, 100% correct answers and deeply detailed scientific and mathematical rationales.
HESI A2 Practice Test Questions | Full Multi-Section Diagnostic Mock Exam 2026
Which of the following is NOT a function of the digestive tract?
a) to use enzymes to break down food
b) to perform gas exchange
c) to remove waste from the body
d) to use peristalsis to move food along
b) to perform gas exchange
Gas exchange is a function of the respiratory system
The body, at all times, attempts to maintain homeostasis. The best definition of homeostasis is:
a) a process that maintains the stability of the human body's internal environment in response to
changes in internal and external conditions
b) a function via which the body breaks down glucose to use as energy
c)a process that maintains the immune system's defenses
d) a process in which the body resists change to genetic structure
a) a process that maintains the stability of the human body's internal environment in response to changes in
internal and external conditions
The endocrine system of the body is responsible for:
a) defense through the use of antibodies
b) communication through the use of hormones
c) metabolism through the use of enzymes
d) blood flow through the use of the heart muscle
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b) communication through the use of hormones
Anatomical position shows the body in a(n) ________ position.
a) lateral
b) superior
c) anterior
d) posterior
c) anterior
Vitamin K is created in the:
a) liver
b) lungs
c) intestinal tract
d) pancreas
c) intestinal tract
The largest organ in the body is the ________.
a) skin
b) GI tract
c) femur
d) stomach
a) skin
A medical scientists wants to study the parenchyma of the kidney. This scientist would correctly be
known, most specifically, as a:
a) biologist
b) doctor
c) anatomist
d) histologist
d) histologist
Histology is the study of tissues.
What is Erythropoiesis?
a) red blood cell formation
b) white blood cell formation
c) the destruction of red blood cells
d) the destruction of white blood cells
a) red blood cell formation
Blood cell formation is called Hemopoiesis.
Erythro- red blood cells
In which part of the body is keratin NOT found?
a) hair
b) skin
Confidential | 2026 Edition Page 2
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c) nails
d) teeth
d) teeth
Keratin is a family of fibrous structural proteins. Keratin is the key structural component of hair, nails, and
the outer layer of human skin
What is the relationship between sarcomeres and muscle cells?
a) sarcomeres are muscle cells
b) sarcomeres contain muscle cells
c) muscle cells contain myofibrils, which in turn are made up of sarcomeres
d) muscle cells contain sarcomeres, which in turn are made up of myofibrils
c) muscle cells contain myofibrils, which in turn are made up of sarcomeres
A person who has torn their vastus lateralis muscle will need which of the following?
a) an arm sling
b) a cane or crutches
c) insulin
d) a neck brace
b) a cane or crutches
The vastus lateralis muscle is a voluntary muscle in the legs. It is part of the quadriceps.
Muscles produce contraction due to the sliding of:
a) filaments
b) sarcomeres
c) flexors
d) neutrons
a) filaments
During muscle contraction, filaments slide together by using energy supplied by ATP.
The medulla oblongata has what primary responsibility?
a) balance
b) intellect
c) vital functions
d) sensory input
c) vital functions
The medulla oblongata is responsible for basic vital functions, including respiration and heart rate.
Which of the following is true about simple reflexes?
a) they travel through the entire body
b) they travel only through the spinal cord
c) they travel only through the brain
Confidential | 2026 Edition Page 3
Actual HESI A2 Practice Test
Questions | Full Multi-Section
Diagnostic Mock Exam 2026
NAME: DATE:
Secure your competitive nursing school admission by acing the HESI A2 entrance exam on your very first try
with this exhaustive, multi-subject practice test package. Mapped meticulously to the official 2026 Elsevier
testing specifications, this high-converting marketplace resource delivers an elite collection of realistic mock
questions featuring verified, 100% correct answers and deeply detailed scientific and mathematical rationales.
HESI A2 Practice Test Questions | Full Multi-Section Diagnostic Mock Exam 2026
Which of the following is NOT a function of the digestive tract?
a) to use enzymes to break down food
b) to perform gas exchange
c) to remove waste from the body
d) to use peristalsis to move food along
b) to perform gas exchange
Gas exchange is a function of the respiratory system
The body, at all times, attempts to maintain homeostasis. The best definition of homeostasis is:
a) a process that maintains the stability of the human body's internal environment in response to
changes in internal and external conditions
b) a function via which the body breaks down glucose to use as energy
c)a process that maintains the immune system's defenses
d) a process in which the body resists change to genetic structure
a) a process that maintains the stability of the human body's internal environment in response to changes in
internal and external conditions
The endocrine system of the body is responsible for:
a) defense through the use of antibodies
b) communication through the use of hormones
c) metabolism through the use of enzymes
d) blood flow through the use of the heart muscle
Confidential | 2026 Edition Page 1
,Doc 001
b) communication through the use of hormones
Anatomical position shows the body in a(n) ________ position.
a) lateral
b) superior
c) anterior
d) posterior
c) anterior
Vitamin K is created in the:
a) liver
b) lungs
c) intestinal tract
d) pancreas
c) intestinal tract
The largest organ in the body is the ________.
a) skin
b) GI tract
c) femur
d) stomach
a) skin
A medical scientists wants to study the parenchyma of the kidney. This scientist would correctly be
known, most specifically, as a:
a) biologist
b) doctor
c) anatomist
d) histologist
d) histologist
Histology is the study of tissues.
What is Erythropoiesis?
a) red blood cell formation
b) white blood cell formation
c) the destruction of red blood cells
d) the destruction of white blood cells
a) red blood cell formation
Blood cell formation is called Hemopoiesis.
Erythro- red blood cells
In which part of the body is keratin NOT found?
a) hair
b) skin
Confidential | 2026 Edition Page 2
, Doc 001
c) nails
d) teeth
d) teeth
Keratin is a family of fibrous structural proteins. Keratin is the key structural component of hair, nails, and
the outer layer of human skin
What is the relationship between sarcomeres and muscle cells?
a) sarcomeres are muscle cells
b) sarcomeres contain muscle cells
c) muscle cells contain myofibrils, which in turn are made up of sarcomeres
d) muscle cells contain sarcomeres, which in turn are made up of myofibrils
c) muscle cells contain myofibrils, which in turn are made up of sarcomeres
A person who has torn their vastus lateralis muscle will need which of the following?
a) an arm sling
b) a cane or crutches
c) insulin
d) a neck brace
b) a cane or crutches
The vastus lateralis muscle is a voluntary muscle in the legs. It is part of the quadriceps.
Muscles produce contraction due to the sliding of:
a) filaments
b) sarcomeres
c) flexors
d) neutrons
a) filaments
During muscle contraction, filaments slide together by using energy supplied by ATP.
The medulla oblongata has what primary responsibility?
a) balance
b) intellect
c) vital functions
d) sensory input
c) vital functions
The medulla oblongata is responsible for basic vital functions, including respiration and heart rate.
Which of the following is true about simple reflexes?
a) they travel through the entire body
b) they travel only through the spinal cord
c) they travel only through the brain
Confidential | 2026 Edition Page 3
