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Master Study Guide: Nucleic Acid Chemistry & DNA TopologyThis document combines organic chemistry fundamentals with advanced molecular biology to explain how genetic material is structured, packaged, and manipulated inside the cell.

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Professor Dr Zahid Azeem
BIOCHEMISTRY
PhD, CHPE, DHPE MHPE

,Early discovery
Early discovery of DNAin 1953 and subsequent
elucidation of how DNA directs synthesis of
RNA, which directs assembly of protein– the
co called central dogma were monumental
achievements marking early days of
molecular biology.

,Central Dogma of Molecular Biology

, Nucleic Acid
Two type of chemically similar nucleic acids
a.Deoxyribonucleic acid (DNA) and
b.ribonucleic acid (RNA)
are principle information carrying molecules of
the cell

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