TEST BANKd
Cellular and Molecular Immunology
d d d
Abul Abbas, Andrew Lichtman, and Shiv Pillai
d d d d d d
10th Edition
d
,Table of Contents
d d
Chapter 01 Properties and Overview of Immune Responses
d d d d d d d 1
Chapter 02 Cells and Tissues of the Immune System
d d d d d d d d 3
Chapter 03 Leukocyte Circulation and Migration Into Tissues
d d d d d d d 6
Chapter 04 Innate Immunity
d d d 10
Chapter 05 Antibodies and Antigens
d d d d 17
Chapter 06 Antigen Presentation to T Lymphocytes and the Functions of Major
d d d d d d d d d d d
Histocompatibility Complex Moleculesd d 20
Chapter 07 Immune Receptors and Signal Transduction
d d d d d d 27
Chapter 08 Lymphocyte Development and Antigen Receptor Gene Rearrangement
d d d d d d d d 30
Chapter 09 Activation of T Lymphocytes
d d d d d 34
Chapter d 10 Differentiation and Functions of CD4+ Effector T Cells
d d d d d d d d 38
Chapter d 11 Differentiation and Functions of CD8+ Effector T Cells
d d d d d d d d 42
Chapter d 12 B Cell Activation and Antibody Production
d d d d d d 46
Chapter d 13 Effector Mechanisms of Humoral Immunity
d d d d d 52
Chapter d 14 Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues
d d d d d d d d d d 56
Chapter d 15 Immunologic Tolerance and Autoimmunity
d d d d 62
Chapter d 16 Immunity to Microbes
d d d 67
Chapter d 17 d Transplantation Immunology d 72
Chapter d 18 d Tumor Immunology
d 77
Chapter d 19 d Hypersensitivity Disorders d 81
Chapter d 20 d Allergy 86
Chapter d 21 d Primary and Acquired Immunodeficiencies
d d d 89
,Chapter 01: Properties and Overview of Immune Responses
d d d d d d d
Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
d d d d d d d d d
MULTIPLE CHOICE d
1. The principal function of the immune system is:
d d d d d d d
a. Defense against cancer d d
b. Repair of injured tissues d d d
c. Defense against microbial infections d d d
d. Prevention of inflammatory diseases d d d
e. Protection against environmental toxins d d d
ANS: C
The immune system has evolved in the setting of selective pressures imposed by
d d d d d d d d d d d d
microbial infections. Although immune responses to cancer may occur, the concept that
d d d d d d d d d d d d
―immunosurveillance‖ against cancer is a principal function of the immune system is
d d d d d d d d d d d d
controversial. Repair of injured tissues may be a secondary consequence of the
d d d d d d d d d d d d
immune responses and inflammation. Although the immune system has regulatory features
d d d d d d d d d d d
that are needed to prevent excessive inflammation, prevention of inflammatory
d d d d d d d d d d
diseases is not a
d d d d
primary function. The immune system can protect against microbial toxins, but it generally
d d d d d d d d d d d d
does not offer protection against toxins of nonbiologic origin.
d d d d d d d d d
2. Which of the following infectious diseases was prevented by the first
d d d d d d d d d d
successful vaccination?
d d
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: C
In 1798, Edward Jenner reported the first intentional successful vaccination, which
d d d d d d d d d d
was against smallpox in a boy, using material from the cowpox pustules of a milkmaid.
d d d d d d d d d d d d d d d
In 1980, smallpox was reported to be eradicated worldwide by a vaccination
d d d d d d d d d d d d
program.
d
Effective vaccines against tetanus toxin, rubella virus, and poliovirus were developed
d d d d d d d d d d
in the 20th century and are widely used. There is no effective vaccine against
d d d d d d d d d d d d d d
Mycobacterium tuberculosis.
d d
3. Which of the following is a unique property of the adaptive immune system?
d d d d d d d d d d d d
a. Highly diverse repertoire of specificities for antigens d d d d d d
b. Self-nonself discrimination d
c. Recognition of microbial structures by both cell-associated and soluble receptors d d d d d d d d d
d. Protection against viral infections d d d
e. Responses that have the same kinetics and magnitude on repeated exposure to the d d d d d d d d d d d d
same microbe d d
ANS: A
, Highly diverse repertoires of specificities for antigens are found only in T and B
d d d d d d d d d d d d d
lymphocytes, which are the central cellular components of the adaptive immune
d d d d d d d d d d d
system. Both the innate and the adaptive immune systems use cell-associated and
d d d d d d d d d d d d
soluble receptors to recognize microbes, display some degree of self-nonself
d d d d d d d d d d
ddiscrimination, and protect against viruses. On repeated exposure to the same microbe, d d d d d d d d d d d
the adaptive immune response becomes more rapid and of greater magnitude; this
d d d d d d d d d d d d
dis the manifestation of memory.
d d d d
4. Antibodies and T lymphocytes are the respective mediators of which two types of
d d d d d d d d d d d d
immunity?
d
a. Innate and adaptive d d
b. Passive and active d d
c. Specific and nonspecific d d
d. Humoral and cell-mediated d d
e. Adult and neonatal d d
ANS: D
Both B and T lymphocytes are principal components of adaptive immunity. B
d d d d d d d d d d d
lymphocytes produce antibodies, which are the recognition and effector molecules of
d d d d d d d d d d d
d humoral immune responses to extracellular pathogens. T cells recognize and promote
d d d d d d d d d d
d eradication of intracellular pathogens in cell-mediated immunity. Passive and active d d d d d d d d d
immunity both can be mediated by either B or T lymphocytes. Specific immunity
d d d d d d d d d d d d d
dis another term for adaptive immunity. Both B and T lymphocytes participate in
d d d d d d d d d d d d
dadult adaptive immunity but are still developing in the neonatal period.
d d d d d d d d d d
5. The two major functional classes of effector T lymphocytes are:
d d d d d d d d d
a. Helper T lymphocytes and cytotoxic T lymphocytes d d d d d d
b. Natural killer cells and cytoWtoWxW
ic.TTlB
yS
mMph.oW
cyStes d d d d
c. Memory T cells and effector T cells d d d d d d
d. Helper cells and antigen-presenting cells d d d d
e. Cytotoxic T lymphocytes and target cells d d d d d
ANS: A
T cells can be classified into effector subsets that perform different effector functions.
d d d d d d d d d d d d
Most effector T cells are either helper T lymphocytes, which enhance the responses
d d d d d d d d d d d d d
of other immune cells, including phagocytes and B cells, to infections, or
d d d d d d d d d d d d
cytotoxic T lymphocytes, which directly kill infected cells. Natural killer cells are
d d d d d d d d d d d d
not T lymphocytes.
d d d
Antigen-presenting cells usually are not T cells. Memory T cells are not effector T cells. d d d d d d d d d d d d d d
6. Which of the following cell types is required for all adaptive humoral immune responses?
d d d d d d d d d d d d d
a. Natural killer cells d d
b. Dendritic cells d
c. Cytolytic T lymphocytes d d
d. B lymphocytes d
e. Helper T lymphocytes d d
ANS: D
Humoral immune responses are antibody-mediated immune responses, and all antibodies
d d d d d d d d d
are made by B lymphocytes and no other cell type.
d d d d d d d d d d
Cellular and Molecular Immunology
d d d
Abul Abbas, Andrew Lichtman, and Shiv Pillai
d d d d d d
10th Edition
d
,Table of Contents
d d
Chapter 01 Properties and Overview of Immune Responses
d d d d d d d 1
Chapter 02 Cells and Tissues of the Immune System
d d d d d d d d 3
Chapter 03 Leukocyte Circulation and Migration Into Tissues
d d d d d d d 6
Chapter 04 Innate Immunity
d d d 10
Chapter 05 Antibodies and Antigens
d d d d 17
Chapter 06 Antigen Presentation to T Lymphocytes and the Functions of Major
d d d d d d d d d d d
Histocompatibility Complex Moleculesd d 20
Chapter 07 Immune Receptors and Signal Transduction
d d d d d d 27
Chapter 08 Lymphocyte Development and Antigen Receptor Gene Rearrangement
d d d d d d d d 30
Chapter 09 Activation of T Lymphocytes
d d d d d 34
Chapter d 10 Differentiation and Functions of CD4+ Effector T Cells
d d d d d d d d 38
Chapter d 11 Differentiation and Functions of CD8+ Effector T Cells
d d d d d d d d 42
Chapter d 12 B Cell Activation and Antibody Production
d d d d d d 46
Chapter d 13 Effector Mechanisms of Humoral Immunity
d d d d d 52
Chapter d 14 Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues
d d d d d d d d d d 56
Chapter d 15 Immunologic Tolerance and Autoimmunity
d d d d 62
Chapter d 16 Immunity to Microbes
d d d 67
Chapter d 17 d Transplantation Immunology d 72
Chapter d 18 d Tumor Immunology
d 77
Chapter d 19 d Hypersensitivity Disorders d 81
Chapter d 20 d Allergy 86
Chapter d 21 d Primary and Acquired Immunodeficiencies
d d d 89
,Chapter 01: Properties and Overview of Immune Responses
d d d d d d d
Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
d d d d d d d d d
MULTIPLE CHOICE d
1. The principal function of the immune system is:
d d d d d d d
a. Defense against cancer d d
b. Repair of injured tissues d d d
c. Defense against microbial infections d d d
d. Prevention of inflammatory diseases d d d
e. Protection against environmental toxins d d d
ANS: C
The immune system has evolved in the setting of selective pressures imposed by
d d d d d d d d d d d d
microbial infections. Although immune responses to cancer may occur, the concept that
d d d d d d d d d d d d
―immunosurveillance‖ against cancer is a principal function of the immune system is
d d d d d d d d d d d d
controversial. Repair of injured tissues may be a secondary consequence of the
d d d d d d d d d d d d
immune responses and inflammation. Although the immune system has regulatory features
d d d d d d d d d d d
that are needed to prevent excessive inflammation, prevention of inflammatory
d d d d d d d d d d
diseases is not a
d d d d
primary function. The immune system can protect against microbial toxins, but it generally
d d d d d d d d d d d d
does not offer protection against toxins of nonbiologic origin.
d d d d d d d d d
2. Which of the following infectious diseases was prevented by the first
d d d d d d d d d d
successful vaccination?
d d
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: C
In 1798, Edward Jenner reported the first intentional successful vaccination, which
d d d d d d d d d d
was against smallpox in a boy, using material from the cowpox pustules of a milkmaid.
d d d d d d d d d d d d d d d
In 1980, smallpox was reported to be eradicated worldwide by a vaccination
d d d d d d d d d d d d
program.
d
Effective vaccines against tetanus toxin, rubella virus, and poliovirus were developed
d d d d d d d d d d
in the 20th century and are widely used. There is no effective vaccine against
d d d d d d d d d d d d d d
Mycobacterium tuberculosis.
d d
3. Which of the following is a unique property of the adaptive immune system?
d d d d d d d d d d d d
a. Highly diverse repertoire of specificities for antigens d d d d d d
b. Self-nonself discrimination d
c. Recognition of microbial structures by both cell-associated and soluble receptors d d d d d d d d d
d. Protection against viral infections d d d
e. Responses that have the same kinetics and magnitude on repeated exposure to the d d d d d d d d d d d d
same microbe d d
ANS: A
, Highly diverse repertoires of specificities for antigens are found only in T and B
d d d d d d d d d d d d d
lymphocytes, which are the central cellular components of the adaptive immune
d d d d d d d d d d d
system. Both the innate and the adaptive immune systems use cell-associated and
d d d d d d d d d d d d
soluble receptors to recognize microbes, display some degree of self-nonself
d d d d d d d d d d
ddiscrimination, and protect against viruses. On repeated exposure to the same microbe, d d d d d d d d d d d
the adaptive immune response becomes more rapid and of greater magnitude; this
d d d d d d d d d d d d
dis the manifestation of memory.
d d d d
4. Antibodies and T lymphocytes are the respective mediators of which two types of
d d d d d d d d d d d d
immunity?
d
a. Innate and adaptive d d
b. Passive and active d d
c. Specific and nonspecific d d
d. Humoral and cell-mediated d d
e. Adult and neonatal d d
ANS: D
Both B and T lymphocytes are principal components of adaptive immunity. B
d d d d d d d d d d d
lymphocytes produce antibodies, which are the recognition and effector molecules of
d d d d d d d d d d d
d humoral immune responses to extracellular pathogens. T cells recognize and promote
d d d d d d d d d d
d eradication of intracellular pathogens in cell-mediated immunity. Passive and active d d d d d d d d d
immunity both can be mediated by either B or T lymphocytes. Specific immunity
d d d d d d d d d d d d d
dis another term for adaptive immunity. Both B and T lymphocytes participate in
d d d d d d d d d d d d
dadult adaptive immunity but are still developing in the neonatal period.
d d d d d d d d d d
5. The two major functional classes of effector T lymphocytes are:
d d d d d d d d d
a. Helper T lymphocytes and cytotoxic T lymphocytes d d d d d d
b. Natural killer cells and cytoWtoWxW
ic.TTlB
yS
mMph.oW
cyStes d d d d
c. Memory T cells and effector T cells d d d d d d
d. Helper cells and antigen-presenting cells d d d d
e. Cytotoxic T lymphocytes and target cells d d d d d
ANS: A
T cells can be classified into effector subsets that perform different effector functions.
d d d d d d d d d d d d
Most effector T cells are either helper T lymphocytes, which enhance the responses
d d d d d d d d d d d d d
of other immune cells, including phagocytes and B cells, to infections, or
d d d d d d d d d d d d
cytotoxic T lymphocytes, which directly kill infected cells. Natural killer cells are
d d d d d d d d d d d d
not T lymphocytes.
d d d
Antigen-presenting cells usually are not T cells. Memory T cells are not effector T cells. d d d d d d d d d d d d d d
6. Which of the following cell types is required for all adaptive humoral immune responses?
d d d d d d d d d d d d d
a. Natural killer cells d d
b. Dendritic cells d
c. Cytolytic T lymphocytes d d
d. B lymphocytes d
e. Helper T lymphocytes d d
ANS: D
Humoral immune responses are antibody-mediated immune responses, and all antibodies
d d d d d d d d d
are made by B lymphocytes and no other cell type.
d d d d d d d d d d
