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1. What is pyelonephritis?
A. A fungal infection of the bladder
B. A kidney stone causing ureteral obstruction
C. A UTI that spreads to the kidneys
D. Inflammation of the renal pelvis from autoimmune disease
Pyelonephritis is a urinary tract infection that has spread to one or both kidneys. It
is an upper UTI distinguished from lower UTI (cystitis) by the involvement of renal
tissue, and is a serious infection that can lead to kidney damage or sepsis if
untreated.
2. What are the most common causative organisms of pyelonephritis?
A. Staphylococcus aureus and Candida albicans
B. Escherichia coli and Enterococcus faecalis
C. Klebsiella and Pseudomonas
D. Streptococcus and Proteus mirabilis
,E. coli is the most common cause of pyelonephritis, responsible for approximately
80% of cases. Enterococcus faecalis is another common gram-positive causative
organism. Both are common intestinal flora that ascend the urinary tract to infect
the kidneys.
3. How does acute pyelonephritis differ from chronic pyelonephritis?
A. Acute is caused by fungi; chronic is caused by bacteria
B. Acute affects both kidneys; chronic affects only one
C. Acute is an active bacterial infection; chronic occurs with structural deformities,
urinary stasis, obstruction, or reflux
D. Acute is painless; chronic presents with severe flank pain
Acute pyelonephritis is an active bacterial infection presenting with sudden onset
of fever and flank pain. Chronic pyelonephritis develops over time — often
secondary to structural abnormalities (vesicoureteral reflux, obstruction, urinary
stasis) that cause repeated infections and progressive renal scarring.
4. What are the classic signs and symptoms of ACUTE pyelonephritis?
A. Hypertension, nocturia, and hyperkalemia
B. Frequency, dysuria, and suprapubic pain only
C. Fever, chills, tachycardia, tachypnea, flank/back/loin pain, CVA tenderness, and
abdominal discomfort
D. Confusion, decreased urine concentration, and metabolic acidosis
Acute pyelonephritis presents with systemic infection signs: fever (often high-
grade), chills, tachycardia, and tachypnea — indicating a systemic inflammatory
response. Local signs include flank, back, or loin pain and costovertebral angle
(CVA) tenderness on percussion, indicating renal involvement.
, 5. What are the signs and symptoms of CHRONIC pyelonephritis?
A. Fever, chills, and CVA tenderness
B. Hypertension, inability to conserve sodium, nocturia, hyperkalemia, and
metabolic acidosis
C. Hematuria, urgency, and suprapubic pain
D. Severe flank pain, restlessness, and diaphoresis
Chronic pyelonephritis manifests as progressive renal dysfunction: hypertension
(damaged kidneys cannot regulate BP), impaired sodium conservation, decreased
urine concentration (causing nocturia), hyperkalemia, and metabolic acidosis — all
reflecting loss of normal tubular and glomerular function over time.
6. Who is most commonly affected by pyelonephritis?
A. Elderly men with BPH
B. Children under age 5 with congenital abnormalities
C.Sexually active young females
D. Immunocompromised patients on chemotherapy
Sexually active young females are the most commonly affected population.
Women are anatomically predisposed (shorter urethra, proximity of urethra to
rectum), and sexual activity increases bacterial introduction into the urethra.
Catheter use, pregnancy, and diabetes are additional risk factors.
7. What psychosocial factors should nurses assess in patients with
pyelonephritis?
A. Financial stress related to hospital bills
B. Body image disturbance from weight changes