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ABFM ITE Exam 2026 Actual Test Bank | American Board of Family Medicine In-Training Exam | 200 Questions with Correct Answers & Detailed Rationales | Latest Update

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Pass your ABFM In-Training Exam (ITE) with confidence. This comprehensive practice test bank contains 200 original, high-yield questions written in the official ABFM ITE style, complete with detailed rationales explaining correct answers and why distractors are wrong. Updated for the 2026 testing cycle, this study guide mirrors the actual ABFM ITE blueprint. What's included in this exam bank: Section 1: Care of Adults and Older Adults (Questions 1-20) Hypertension management – NSAID-induced BP elevation, ACE inhibitor adjustment Atrial fibrillation & apixaban dose adjustment in CKD (eGFR 15-29 → 2.5 mg BID) COPD management – GOLD guidelines, tiotropium, pulmonary rehabilitation Alzheimer's agitation – atypical antipsychotics (risperidone) after non-pharmacologic failure Osteoporosis bisphosphonate drug holiday (after 5 years, T-score -2.5 without fracture) Type 2 diabetes with CKD and HFpEF – insulin glargine (SGLT2i not effective at eGFR 45) Advanced dementia & tube feeding – no benefit, focus on goals of care Amlodipine edema – switch to ACE inhibitor (lisinopril) Acute gout in CKD – prednisone (avoid NSAIDs, colchicine requires dose adjustment) Elevated PSA with rapid rise – multiparametric MRI before biopsy Hypertension in diabetes with albuminuria – intensify with ACEi + thiazide HFrEF optimization – switch ACEi to sacubitril/valsartan (PARADIGM-HF) Nephrolithiasis (6mm ureteral stone) – medical expulsive therapy (tamsulosin) Early-stage NSCLC in medically inoperable patient – SBRT AAA screening – one-time ultrasound for men aged 65-75 who ever smoked (USPSTF) Stroke on DOAC – continue apixaban, evaluate for other causes Resistant hypertension in CKD – add chlorthalidone (preferred over HCTZ) Atrial fibrillation with GERD – apixaban (no food requirement) Acute heart failure – echocardiogram to differentiate HFpEF vs. HFrEF High ASCVD risk in diabetes – add empagliflozin (reduces CV death) Section 2: Care of Children and Adolescents (Questions 21-40) Neonatal hypertension – renal ultrasound + creatinine (screen for secondary causes) CF diagnosis – intermediate sweat chloride → CFTR genetic testing Osgood-Schlatter disease – activity modification + quadriceps stretching Bacterial meningitis CSF profile – low glucose, high protein, neutrophilic pleocytosis Appendicitis – non-compressible appendix 6mm on ultrasound → appendectomy Febrile seizure – simple febrile seizure → treat infection, no antiepileptics Minimal change disease – nephrotic syndrome in child → corticosteroids Step-up asthma therapy (medium-dose ICS, not well-controlled) – add LABA Hyperthyroidism in adolescent – methimazole (avoid RAI in young) Bronchodilator response – FEV1 increase ≥12% and ≥200 mL from baseline Intussusception – air contrast enema (diagnostic + therapeutic) CF pathophysiology – decreased Cl- secretion + increased Na+ absorption Palivizumab RSV prophylaxis – indicated for infants 29 weeks with CLD or CHD Septic arthritis vs. transient synovitis – Kocher criteria: fever 38.5°C, ESR ≥40 Rheumatic fever secondary prophylaxis – benzathine penicillin G IM q4 weeks Acute asthma exacerbation – SABA via MDI with spacer (4-8 puffs q20 min) Measles complications – otitis media and pneumonia (most common) Hypernatremic dehydration – initial resuscitation with 0.9% normal saline Slit ventricle syndrome – intermittent ICP symptoms with small ventricles on CT Section 3: Care of Pregnant and Postpartum Patients (Questions 41-60) Preeclampsia with severe features (thrombocytopenia) – MgSO4, delivery at 34 weeks TOLAC contraindication – previous classical uterine incision Postpartum preeclampsia – hypertension + proteinuria + hyperreflexia after delivery GDM screening – 50g OGCT non-fasting at 24-28 weeks Fundal height 2cm above expected – multiple gestation Postpartum PE – CTPA for diagnosis Placenta previa – admit, betamethasone, no digital exam Contraindicated vaccines in pregnancy – MMR, varicella, live attenuated influenza Nonreactive NST – biophysical profile (BPP) Breastfeeding antihypertensive – labetalol (low milk transfer) Severe preeclampsia feature – new-onset headache unresponsive to medication Unknown uterine scar – absolute contraindication to TOLAC Postpartum endometritis after C-section – anaerobes (Bacteroides fragilis), foul lochia Acute asthma in pregnancy – inhaled albuterol (first-line) Magnesium toxicity – oliguria (30 mL/hour) → discontinue Section 4: Care of Patients with Acute and Chronic Conditions (Questions 61-80) STEMI management – aspirin + thrombolytics if PCI not available within 120 minutes Resistant HTN in CKD stage 3 – add chlorthalidone COPD exacerbation (purulent sputum) – amoxicillin-clavulanate Partial response to SSRI in MDD – increase to maximum tolerated dose Hypertension in high-risk patient (BMI 34, IFG) – pharmacotherapy at ≥130/80 mmHg Hepatic encephalopathy – oral lactulose (first-line) Subtherapeutic INR on warfarin – resume usual dose without bridging Calcium oxalate stones with hypercalciuria – HCTZ (thiazide) Persistent HFrEF symptoms on GDMT – switch ACEi to sacubitril/valsartan (ARNI) Recurrent C. difficile – bezlotoxumab for prevention (after multiple recurrences) Acute aortic dissection – IV labetalol + CT angiography COPD hypercapnic respiratory failure – NIPPV (IPAP 10-15, EPAP 4-6) Cardiogenic shock on GDMT – IV dobutamine (inotrope) HHS initial fluid resuscitation – 0.9% normal saline Normocalcemic primary hyperparathyroidism – elevated PTH, normal calcium, elevated urine calcium Bleeding gastric ulcer on prednisone – PPI + test/treat H. pylori Acute pulmonary edema in CKD stage 4 – IV furosemide (loop diuretic) Life-threatening bleed on warfarin (INR 3.5, ICH) – PCC (4-factor) Acute variceal bleeding – octreotide IV bolus + infusion Section 5: Preventive Medicine and Health Promotion (Questions 81-100) Lung cancer screening (USPSTF) – annual LDCT for ages 50-80, 20 pack-year, quit within 15 years Aspirin for primary prevention – ages 50-59 with 10-year CVD risk ≥10%, not at increased bleeding risk Diabetes screening in overweight/obese adults – start at age 35 (USPSTF) HPV vaccination – recommended through age 26 (3-dose series if started after 15) Colorectal cancer screening with family history (1st degree diagnosed at 50) – start at age 40, colonoscopy q5 years Unhealthy alcohol use screening – AUDIT-C + brief counseling GDM history – lifelong screening with 75g OGTT at least every 3 years Vaccines in pregnancy – inactivated influenza + Tdap (27-36 weeks) Mammography with 1st degree relative breast cancer – start at age 40 (biennial) HIV screening in IV drug user – at least annually while risk behaviors continue Section 6: Behavioral and Mental Health (Questions 101-120) Melancholic depression – anhedonia + lack of mood reactivity + psychomotor retardation GAD inadequate response to SSRI – switch to SNRI (venlafaxine or duloxetine) Lithium toxicity (level 2.1) – discontinue, IV fluids, consider hemodialysis PTSD nightmares – prazosin (alpha-1 antagonist) OCD first-line – exposure and response prevention (ERP) + SSRI Schizophrenia negative symptoms – add aripiprazole (partial dopamine agonist) Alcohol use disorder with cirrhosis – naltrexone contraindicated (hepatotoxicity) ADHD with comorbid GAD – atomoxetine (nonstimulant, does not worsen anxiety) BPD self-harm – no medication has strong evidence (DBT is first-line) Suicide prevention post-discharge – means restriction (remove firearms, lock up medications) Inadequate SSRI response in MDD – augment with CBT (strongest evidence for remission) Bipolar I mania (≥7 days) – meets criteria for manic episode GAD inadequate response to pregabalin – switch to venlafaxine XR (first-line SNRI) BPD relapse prevention – DBT (strongest evidence) Clozapine ANC monitoring – ANC → continue with twice-weekly monitoring Bulimia nervosa FDA-approved medication – fluoxetine 60 mg daily Section 7: Musculoskeletal, Skin, and Rheumatic Diseases (Questions 121-140) Patellofemoral pain – quadriceps strengthening, patellar taping Giant cell arteritis – temporal artery biopsy can be positive up to 2-4 weeks after starting steroids Basal cell carcinoma (nose) – Mohs micrographic surgery (high-risk area) Acute gout – avoid starting allopurinol during flare (can exacerbate) Tinea cruris – topical terbinafine 1% BID for 1 week Axial spondyloarthritis – MRI with STIR (detects bone marrow edema) Erythema multiforme major – target lesions on palms/soles + mucosal involvement Systemic sclerosis – anti-centromere antibodies (CREST syndrome) Lumbar disc herniation with radiculopathy – epidural corticosteroid injection Acanthosis nigricans – associated with type 2 diabetes (insulin resistance) Gout – negatively birefringent crystals → allopurinol for long-term prevention Psoriatic arthritis – methotrexate (first-line DMARD) Foot osteomyelitis in diabetic – surgical debridement + bone biopsy (gold standard) Malignant melanoma stage III (positive sentinel node) – adjuvant immunotherapy (pembrolizumab) S1 radiculopathy – absent Achilles reflex, weakness of plantarflexion First-degree AV block – PR interval 200 ms (delay in AV node) Septic arthritis (Staph aureus) – empiric vancomycin (cover MRSA) Psoriasis vulgaris – well-demarcated plaques with silvery scale on extensor surfaces Section 8: Infectious Diseases and Immunizations (Questions 141-160) Herpes zoster – valacyclovir 1g TID for 7 days (start within 72 hours) LAIV contraindication in healthcare workers – risk of transmission to immunocompromised patients Pyelonephritis in CKD stage 3 – ceftriaxone 1g IV daily (no dose adjustment) Frequent genital HSV recurrences (≥6/year) – daily suppressive valacyclovir 500 mg PCV13 herd immunity – reduces nasopharyngeal carriage of vaccine-type strains Splenectomy vaccination sequence – PCV13 now, PPSV23 at least 8 weeks later Early localized Lyme disease – doxycycline 100 mg BID for 10 days Uncomplicated gonococcal cervicitis – ceftriaxone 500 mg IM + azithromycin 1g PO Varicella vaccine contraindication – anaphylaxis to neomycin HIV (CD4 200) hepatitis B vaccination – 4-dose high-dose series (40 mcg) Influenza with egg anaphylaxis – zanamivir (inhaled) Healthcare worker post-needlestick (HBsAg+ source, anti-HBs 10) – HBIG + vaccine booster Asplenia vaccination – MenACWY + serogroup B + Hib HIV PEP (high-risk exposure) – TAF/FTC + dolutegravir (3-drug regimen) Rifampin-resistant TB – isoniazid, pyrazinamide, ethambutol + fluoroquinolone Multiply recurrent C. difficile (≥3 episodes) – fecal microbiota transplantation (FMT) MRSA endocarditis (IV drug user) – daptomycin + ceftaroline Rubella IgM positive after MMR vaccine – incubation at time of vaccination HIV LTBI (CD4 150) – isoniazid 300 mg daily for 9 months + pyridoxine Hepatitis E in pregnancy (third trimester) – high risk of fulminant hepatitis, monitor closely Section 9: Cardiovascular and Pulmonary Medicine (Questions 161-180) Pre-capillary pulmonary hypertension (mPAP 35, PCWP 12) – PAH due to connective tissue disease Nitroprusside mechanism – releases NO → increases cGMP → vasodilation Stress echo anterior wall akinesis – LAD territory COPD GOLD stage – FEV1 45% predicted → GOLD 2 (moderate) STEMI (inferior wall) – aspirin, antiplatelet, transfer for primary PCI Restrictive lung disease – reduced TLC (80% predicted) Atrial fibrillation (CHA2DS2-VASc 3) – apixaban 5 mg BID (DOAC preferred) Reversible airflow obstruction – asthma (FEV1/FVC 0.70 pre-bronchodilator, improves to 0.70) Warfarin INR 5.2 with minor bleeding – hold warfarin + oral vitamin K 1-2.5 mg Non-cardiogenic stroke secondary prevention – clopidogrel 75 mg daily COPD with CAD and ST depression – hypoxemia-induced coronary vasospasm Hemodynamically unstable AF with HFrEF – synchronized cardioversion after TEE Prostacyclin analog (epoprostenol) side effect – thrombocytopenia Restrictive cardiomyopathy – decreased e' on tissue Doppler (vs. constrictive pericarditis) TAVR contraindication – active infective endocarditis Severe ARDS (PaO2/FiO2 120) – prone positioning (improves oxygenation) Acute pericarditis – PR segment depression (specific finding) CTEPH surgical candidacy – proximal (main/lobar) thromboembolic disease Hypertrophic cardiomyopathy exertional syncope – dynamic LVOT obstruction Recurrent PE despite anticoagulation – assess RV function on echo Section 10: Endocrine, Metabolic, and Nutritional Disorders (Questions 181-200) Metformin in CKD stage 4 (eGFR 32) – discontinue metformin, continue glipizide at reduced dose Primary hyperparathyroidism – elevated calcium, elevated PTH, elevated urine calcium Diabetes prevention – intensive lifestyle modification (7% weight loss, 150 min/week activity) Addison's disease – autoimmune adrenalitis (ACTH stimulation test peak cortisol 18) Methimazole in Graves' – TSH suppression persists after T4 normalizes → continue current dose DKA first intervention – IV normal saline (volume resuscitation) Hyperphosphatemia in CKD stage 4 – sevelamer carbonate (calcium-free binder) Metabolic syndrome – 5 components present (obesity, TG ≥150, HDL 40, BP ≥130/85, glucose ≥100) Osteoporotic fracture on alendronate – switch to teriparatide (anabolic agent) B12 deficiency with normal intrinsic factor antibody – dietary deficiency (vegan) Advanced CKD (eGFR 28) with hyperkalemia – discontinue metformin + lisinopril, start DPP-4 inhibitor Hypothyroidism after RAI for Graves' – TSH 10.1 on levothyroxine 75 mcg → increase to 88 mcg Metabolic syndrome with elevated triglycerides – rosuvastatin (statin first-line for CV risk reduction) Diabetic kidney disease (eGFR 38, UACR 450) – add canagliflozin (SGLT2 inhibitor, nephroprotective) Pheochromocytoma – preoperative alpha-blockade (phenoxybenzamine), then beta-blockade HFpEF with diabetes – empagliflozin (reduces CV death + HF hospitalization per EMPEROR-Preserved) GLP-1 RA nausea – reduce dose and titrate more slowly Primary hyperparathyroidism with nephrolithiasis & T-score -2.8 – parathyroidectomy (meets all criteria) Type 1 diabetes with hypoglycemia unawareness – CSII (insulin pump therapy) Key features: 200 questions covering all ABFM ITE content domains Detailed rationales with evidence-based citations (USPSTF, ADA, ACC/AHA, GOLD, GINA, CDC) Clinical pearls for high-yield board exam topics Updated for 2026 – reflects current guidelines Perfect for – ABFM In-Training Exam, Family Medicine Board Review, Residency Program Exams, Family Medicine Certification Last updated: [Insert current month/year] – reflects the latest ABFM ITE blueprint and clinical practice guidelines

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ABFM ITE EXAM NEWEST 2026 ACTUAL EXAM TEST
BANK| AMERICAN BOARD OF FAMILY MEDICINE IN
TRAINING FINAL EXAM REVIEW WITH 200 REAL EXAM
QESTIONS AND CORRECT DETAILED ANSWERS — 200
Questions

Section 1: Care of Adults and Older Adults (Questions 1-20)

1 A 74-year-old patient with a history of hypertension, type 2 diabetes, and osteoarthritis presents for a routine
visit. Current medications include lisinopril 20 mg daily, metformin 1000 mg twice daily, and ibuprofen 600 mg
three times daily as needed for joint pain. Blood pressure is 148/92 mm Hg, heart rate 78 bpm, and creatinine
1.4 mg/dL (baseline 1.0). Which of the following is the most appropriate next step in managing this patient's
hypertension?

A) Add hydrochlorothiazide 12.5 mg daily
B) Increase lisinopril to 40 mg daily
C) Discontinue ibuprofen and reassess blood pressure in 2-4 weeks
D) Add amlodipine 5 mg daily
Answer: C
Rationale: NSAIDs can cause sodium and water retention, increase blood pressure, and impair renal function,
especially in patients on ACE inhibitors. Discontinuing ibuprofen may improve BP control and renal function
without additional antihypertensive therapy. Hydrochlorothiazide or amlodipine could be added if BP remains
elevated after NSAID cessation, but lisinopril should not be increased further given rising creatinine.

2 Which of the following medication adjustments is recommended for an 80-year-old patient with atrial
fibrillation and a CHA2DS2-VASc score of 4 who develops acute kidney injury (creatinine clearance 25
mL/min) while on apixaban?
A) Switch to warfarin with a target INR of 2-3
B) Reduce apixaban dose to 2.5 mg twice daily
C) Continue apixaban 5 mg twice daily with close monitoring
D) Discontinue anticoagulation and consider left atrial appendage closure
Answer: B
Rationale: In patients with creatinine clearance 15-29 mL/min, the apixaban dose should be reduced to 2.5 mg twice
daily if they meet two of three criteria: age "e80 years, weight "d60 kg, or serum creatinine "e1.5 mg/dL. This patient
meets at least age and renal impairment, so dose reduction is indicated. Warfarin may be used but requires frequent
monitoring; however, apixaban is preferred in this setting. Continuing full dose increases bleeding risk.

3 A 68-year-old patient with a 30-pack-year smoking history and mild COPD (post-bronchodilator FEV1/FVC
<0.7, FEV1 65% predicted) reports increasing dyspnea on exertion and occasional wheezing. Current
medications include albuterol as needed. Which of the following is the most appropriate initial step in
management?

A) Start tiotropium daily
B) Start fluticasone-salmeterol twice daily
C) Refer for pulmonary rehabilitation
D) Prescribe a course of oral prednisone

,Answer: A
Rationale: According to GOLD guidelines, for patients with group B COPD (FEV1 <80% predicted, low
exacerbation risk), a long-acting bronchodilator (LAMA or LABA) is recommended as initial therapy. Tiotropium
(LAMA) is a first-line option. Combination ICS/LABA is reserved for patients with high exacerbation risk or
eosinophilia. Pulmonary rehabilitation is adjunctive, and oral steroids are for acute exacerbations.

4 An 82-year-old patient with moderate Alzheimer's disease (MMSE 16) is on donepezil 10 mg daily. The
patient's caregiver reports increased agitation and delusions over the past week. Vital signs are normal, and there
are no signs of infection. Which of the following is the most appropriate next step?
A) Add risperidone 0.5 mg twice daily
B) Increase donepezil to 23 mg daily
C) Discontinue donepezil and start memantine
D) Add sertraline 50 mg daily
Answer: A
Rationale: For severe agitation and psychosis in Alzheimer's disease, atypical antipsychotics like risperidone are
indicated after non-pharmacologic measures fail, with careful monitoring for side effects. The donepezil dose is
already at the maximum for moderate disease (10 mg; 23 mg is for severe). Memantine can be added but does not
acutely treat agitation. Sertraline may help depression but not psychosis.

5 A 76-year-old patient with osteoporosis (T-score -3.2) and a history of a hip fracture 2 years ago is currently on
alendronate 70 mg weekly for 5 years. Recent DXA shows T-score -2.8 at the hip. Which of the following is the
most appropriate management?
A) Continue alendronate for another 5 years
B) Switch to denosumab 60 mg subcutaneously every 6 months
C) Take a 2-year drug holiday and reassess
D) Add teriparatide daily for 2 years
Answer: C
Rationale: After 5 years of bisphosphonate therapy, a drug holiday of 2-3 years is recommended for patients at
moderate risk (T-score > -2.5 without fracture). This patient has T-score -2.8, which is above -3.0, and no recent
fracture, so a holiday is appropriate. Continuing beyond 5 years increases risk of atypical femur fractures.
Denosumab or teriparatide are reserved for those with T-score "d -3.0 or multiple fractures.

6 A 70-year-old patient with type 2 diabetes (HbA1c 8.2%) on metformin 2000 mg daily and glipizide 10 mg
twice daily presents with a fasting glucose of 280 mg/dL and no ketones. The patient has stage 3b CKD (eGFR
35 mL/min/1.73 m²) and a history of heart failure with preserved ejection fraction. Which of the following is
the most appropriate next step in therapy?

A) Start insulin glargine 10 units daily
B) Add empagliflozin 10 mg daily
C) Add sitagliptin 100 mg daily
D) Increase glipizide to 20 mg twice daily
Answer: A
Rationale: Given the patient's poor glycemic control on dual oral therapy, insulin is indicated. Empagliflozin is
relatively contraindicated with eGFR <45 mL/min and may not be effective. Sitagliptin requires dose adjustment
(50 mg daily for eGFR 30-44) but is less potent. Increasing glipizide beyond maximum dose (20 mg/day) is not
recommended and may cause hypoglycemia. Insulin glargine is safe and effective.

,7 An 85-year-old patient with advanced dementia (FAST stage 7c) is admitted with aspiration pneumonia. The
patient is unable to swallow and has a poor appetite. The family requests aggressive treatment including
antibiotics and tube feeding. Which of the following is the most appropriate approach?
A) Initiate parenteral antibiotics and place a nasogastric tube for feeding
B) Provide antibiotics via IV but recommend against tube feeding due to lack of benefit
C) Withhold all life-sustaining treatments and focus on comfort care
D) Consult ethics committee to resolve the conflict
Answer: B
Rationale: In advanced dementia, tube feeding does not improve survival, quality of life, or prevent aspiration; it
may increase discomfort. Antibiotics are reasonable for pneumonia but goals of care should be discussed. Comfort
care is appropriate if the patient's wishes are known, but the family's request for treatment should be honored to
some extent. An ethics consult may be needed if conflict persists, but the best initial step is to explain evidence and
recommend against tube feeding.

8 A 72-year-old patient with a history of hypertension and osteoarthritis is started on amlodipine 5 mg daily. Two
weeks later, the patient reports new-onset bilateral lower extremity edema. Blood pressure is 130/80 mm Hg.
Which of the following is the most appropriate next step?
A) Add hydrochlorothiazide 12.5 mg daily
B) Switch to lisinopril 10 mg daily
C) Reduce amlodipine to 2.5 mg daily
D) Discontinue amlodipine and start metoprolol 25 mg daily
Answer: B
Rationale: Amlodipine causes peripheral edema due to precapillary vasodilation. Switching to an ACE inhibitor
(lisinopril) is effective and may also treat hypertension. Adding a diuretic may reduce edema but does not address
the cause and can cause electrolyte disturbances. Reducing the dose may help but often leads to inadequate BP
control. Metoprolol is not first-line for isolated hypertension in older adults without compelling indications.

9 A 78-year-old patient with a history of gout and stage 3a CKD (eGFR 50 mL/min) presents with an acute gout
flare in the first metatarsophalangeal joint. Current medications include allopurinol 300 mg daily and losartan
50 mg daily. Which of the following is the most appropriate treatment for the acute flare?
A) Indomethacin 50 mg three times daily for 5 days
B) Colchicine 1.2 mg followed by 0.6 mg one hour later
C) Prednisone 40 mg daily for 5 days
D) Intra-articular methylprednisolone acetate 40 mg
Answer: C
Rationale: In patients with CKD, NSAIDs are contraindicated due to risk of further renal impairment. Colchicine
requires dose adjustment for eGFR <50 (maximum 0.6 mg/day) and the loading dose may be toxic. Systemic
corticosteroids (prednisone) are safe and effective for acute gout in renal impairment. Intra-articular steroids are an
option for monoarticular flare but require joint injection expertise and may not be preferred for a first MTP joint.

10 A 75-year-old patient with a history of hypertension, hyperlipidemia, and benign prostatic hyperplasia is found
to have a PSA of 6.5 ng/mL (previous 4.2 one year ago). Digital rectal exam reveals a firm, asymmetric
prostate without nodules. Which of the following is the most appropriate next step?
A) Repeat PSA in 6 months
B) Start finasteride and reassess PSA in 3 months
C) Order multiparametric MRI of the prostate
D) Refer for transrectal ultrasound-guided biopsy

, Answer: C
Rationale: Given the rapid rise in PSA (velocity >0.75 ng/mL/year) and abnormal DRE, further evaluation is
warranted. Multiparametric MRI is recommended before biopsy to identify suspicious lesions and reduce
unnecessary biopsies. Finasteride would lower PSA but delay diagnosis. Repeat PSA in 6 months is not appropriate
with these findings. Biopsy is indicated if MRI shows suspicious areas, but MRI first is the current standard.

11 A 72-year-old patient with a history of hypertension and type 2 diabetes presents with a blood pressure of
148/92 mm Hg on two separate visits. Current medications include lisinopril 10 mg daily, metformin 1000 mg
twice daily, and atorvastatin 20 mg daily. Estimated glomerular filtration rate (eGFR) is 55 mL/min/1.73 m²,
and urine albumin-to-creatinine ratio (UACR) is 45 mg/g. According to the 2017 ACC/AHA hypertension
guideline, what is the most appropriate next step in managing this patient's blood pressure?

A) Continue current therapy and recheck blood pressure in 6 months
B) Increase lisinopril to 20 mg daily and add a thiazide diuretic
C) Add a calcium channel blocker and refer to nephrology
D) Increase lisinopril to 40 mg daily and add spironolactone
Answer: B
Rationale: The patient's blood pressure is above the goal of <130/80 mm Hg for adults with diabetes and CKD
(stage 3a, eGFR 45-59). The UACR is moderately increased (30-300 mg/g), indicating albuminuria. The 2017
ACC/AHA guideline recommends intensifying therapy with two first-line agents (ACEi/ARB and thiazide diuretic)
when BP is >20/10 mm Hg above goal. Increasing lisinopril to 20 mg and adding a thiazide diuretic is appropriate.
Spironolactone is not first-line, and calcium channel blockers are less preferred in albuminuric CKD.

12 A 68-year-old patient with a history of coronary artery disease and heart failure with reduced ejection fraction
(HFrEF, LVEF 35%) is on guideline-directed medical therapy including metoprolol succinate 50 mg daily,
lisinopril 10 mg daily, and furosemide 40 mg daily. The patient reports persistent dyspnea on exertion and
fatigue. Vital signs: BP 110/70 mm Hg, HR 65 bpm, oxygen saturation 97% on room air. Serum creatinine 1.1
mg/dL, potassium 4.2 mEq/L. Which medication adjustment is most likely to improve outcomes?

A) Increase metoprolol succinate to 100 mg daily
B) Add sacubitril/valsartan 24/26 mg twice daily
C) Add spironolactone 12.5 mg daily
D) Increase lisinopril to 20 mg daily
Answer: B
Rationale: In patients with HFrEF who remain symptomatic despite ACEi/ARB, beta-blocker, and diuretic, the
PARADIGM-HF trial demonstrated that switching from ACEi to sacubitril/valsartan reduces cardiovascular death
and heart failure hospitalizations. The patient is on low-dose ACEi and beta-blocker; further up-titration is
reasonable, but the addition of sacubitril/valsartan is a proven next step. Spironolactone is indicated for NYHA
class II-IV with LVEF "d35%, but it is typically added after optimization of ACEi and beta-blocker. The patient's
BP and potassium are acceptable for initiation.

13 A 75-year-old patient with a history of osteoarthritis and hypertension presents with an acute onset of severe,
colicky right flank pain radiating to the groin, associated with nausea and vomiting. Urinalysis shows
hematuria (3+ RBCs) and no signs of infection. Noncontrast CT reveals a 6 mm calculus in the proximal right
ureter with mild hydronephrosis. The patient's serum creatinine is 1.0 mg/dL. Which of the following is the
most appropriate initial management?

A) Immediate ureteroscopic lithotripsy
B) Extracorporeal shock wave lithotripsy (ESWL)
C) Medical expulsive therapy with tamsulosin and hydration
D) Percutaneous nephrostomy tube placement

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