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ANCC AGACNP EXAM – 200 REAL QUESTIONS & VERIFIED ANSWERS | ADULT-GERONTOLOGY ACUTE CARE NURSE PRACTITIONER CERTIFICATION TEST BANK

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Pass your ANCC AGACNP Certification Exam with confidence using this complete test bank of 200 real exam questions and correct answers. Covering every core domain—cardiovascular disorders (acute coronary syndrome, STEMI management, door-to-balloon time, heart failure with reduced ejection fraction (HFrEF), beta-blocker management in acute decompensation, post-cardiac arrest targeted temperature management, permissive hypertension, atrial fibrillation on apixaban with acute limb ischemia, mitral valve prolapse, vasopressors and mechanical circulatory support, acute aortic syndromes), pulmonary disorders (COPD exacerbation with hypercapnic respiratory failure (BiPAP indications), severe ARDS (prone positioning, low tidal volume ventilation, plateau pressure), massive hemoptysis (positioning bleeding side down), pulmonary embolism with thrombolysis complicated by intracranial hemorrhage, idiopathic pulmonary fibrosis (pirfenidone/nintedanib), pneumothorax, pleural effusion, pulmonary hypertension), neurology (acute ischemic stroke (IV tPA window 4.5 hours, NIHSS), subarachnoid hemorrhage with vasospasm (transcranial Doppler 200 cm/s, induced hypertension, intra-arterial verapamil), status epilepticus (second-line levetiracetam or fosphenytoin), delirium due to UTI in elderly, myasthenia gravis crisis vs. cholinergic crisis (edrophonium test, plasmapheresis), Guillain-Barré syndrome, meningitis, brain death exam), renal and electrolyte disorders (acute kidney injury (AKI) in septic shock (MAP optimization), acute tubular necrosis (ATN) from vancomycin/piperacillin-tazobactam (muddy brown casts), severe symptomatic hyponatremia (3% hypertonic saline), hyperkalemia with peaked T waves (insulin/dextrose for intracellular shift), hypomagnesemia with prolonged QT (IV magnesium), contrast nephropathy, acid-base disorders), endocrine and metabolic disorders (diabetic ketoacidosis (DKA) management (insulin drip, dextrose when glucose 250, anion gap closure), severe hypertriglyceridemia with pancreatitis (plasmapheresis), myxedema coma (IV levothyroxine), adrenal crisis (stress-dose IV hydrocortisone 100 mg bolus), hypercalcemia of malignancy (IV bisphosphonate zoledronic acid), SIADH, diabetes insipidus), gastroenterology (infected pancreatic necrosis (percutaneous drainage), spontaneous bacterial peritonitis (SBP) with PMN 250 (cefotaxime plus IV albumin), lower GI bleeding from diverticulosis (endoscopic clipping, observation), postoperative ileus (NGT decompression, bowel rest), acute cholecystitis in high-risk surgical patient (percutaneous cholecystostomy tube), GI bleeding, hepatic encephalopathy), infectious disease (community-acquired pneumonia in elderly with penicillin allergy (respiratory fluoroquinolone), ESBL-producing E. coli septic shock (meropenem), culture-negative endocarditis with prosthetic valve (empiric ampicillin-sulbactam plus gentamicin), hospital-acquired pneumonia (HAP) with MRSA risk (vancomycin plus anti-pseudomonal beta-lactam), cryptococcal meningitis in HIV with CD4100 (amphotericin B plus flucytosine), febrile neutropenia (cefepime monotherapy), sepsis, osteomyelitis), hematology and oncology (acute myeloid leukemia (AML) with febrile neutropenia, warfarin management with INR 4.2 (hold and recheck), multiple myeloma with hypercalcemia and renal failure (IV fluids and bortezomib-dexamethasone), immune thrombocytopenia (ITP) with platelets 8,000 and wet purpura (IVIG), chronic lymphocytic leukemia (CLL) with hypogammaglobulinemia and recurrent infections (IVIG replacement), DIC, TTP), professional role and ethics (goals-of-care conversations in advanced dementia, colleague falsifying documentation (confront then escalate), conscientious objection to medical aid in dying (MAID) with transfer of care, practicing within scope of competence (supervision request), DNR order with pulseless electrical activity (PEA) – confirm and do not start CPR), multisystem and critical care (septic shock with low ScvO2 (start dobutamine), massive transfusion coagulopathy (factor VII deficiency), traumatic brain injury with elevated ICP (head elevation, sedation, osmolar therapy), high peak pressure with normal plateau pressure (increased airway resistance), ARDS from pancreatitis (Berlin criteria), and comprehensive integrated case scenarios—each question includes detailed rationales to strengthen clinical judgment and exam readiness. Perfect for AGACNP students, acute care nurse practitioners, and critical care providers preparing for the ANCC Adult-Gerontology Acute Care Nurse Practitioner certification exam.

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ANCC AGACNP
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Page 1 of 56



ANCC AGACNP EXAM |ACTUAL

500+Qs&As|ALREADY GRADED A+

Q1. A 72-year-old male presents to the ED with substernal chest

pain radiating to the jaw, diaphoresis, and nausea. ECG shows

ST-segment elevation of 3 mm in leads V2–V4. Initial troponin is

0.04 ng/mL (normal <0.03). What is the most appropriate next

action?

a) Repeat troponin in 6 hours

b) Administer IV nitroglycerin and morphine

c) Activate the STEMI team for emergent percutaneous coronary

intervention (PCI)

d) Obtain a chest X-ray

Correct Answer: c) Activate the STEMI team for emergent

percutaneous coronary intervention (PCI)

*Rationale: ST elevation in contiguous leads with symptoms

,Page 2 of 56


indicates acute STEMI. Door-to-balloon time should be <90

minutes. Troponin may be normal initially; do not wait for repeat.

Nitroglycerin is adjunctive, not definitive. PCI is superior to

fibrinolytics if available within 120 minutes.*

Q2. A 68-year-old with HFrEF (EF 30%) presents with worsening

dyspnea, orthopnea, and 4+ pitting edema to the knees. BP

95/60, HR 110, respirations 28, O2 sat 88% on 2L. Which

medication should be held or discontinued?

a) Furosemide 80 mg IV

b) Metoprolol succinate 100 mg daily

c) Spironolactone 25 mg daily

d) IV nitroglycerin drip

Correct Answer: b) Metoprolol succinate 100 mg daily

Rationale: Beta-blockers can worsen acute decompensated heart

failure if the patient is hypoperfused (low BP, tachycardia, cool

extremities). Hold beta-blocker until euvolemia and hemodynamic

,Page 3 of 56


stability are restored. Diuretics, vasodilators, and sometimes

inotropes are first-line.

Q3. A patient post-cardiac arrest has return of spontaneous

circulation (ROSC). ECG shows STEMI. Immediate coronary

angiography is planned. What is the target mean arterial

pressure (MAP) and for how long?

a) MAP > 100 mmHg for 24 hours

b) MAP > 65 mmHg but avoid hypertension

c) MAP 80–100 mmHg with permissive hypertension for first 24

hours

d) MAP 50–60 mmHg to reduce cerebral edema

Correct Answer: c) MAP 80–100 mmHg with permissive

hypertension for first 24 hours

*Rationale: Post-ROSC guidelines (AHA 2020) recommend

avoiding hypotension (MAP <65) and allowing permissive

hypertension (MAP up to 100–110) to improve cerebral

, Page 4 of 56


perfusion. Aggressive BP lowering may worsen neurologic

outcome.*

Q4. A 75-year-old with atrial fibrillation on apixaban presents

with acute left leg pain, pallor, and pulselessness. Capillary refill

>5 seconds. What is the priority?

a) Obtain INR and aPTT

b) Administer IV heparin

c) Emergent surgical consultation for thrombectomy

d) Elevate the leg and apply warmth

Correct Answer: c) Emergent surgical consultation for

thrombectomy

Rationale: Acute limb ischemia with sensory/motor deficits or

impending gangrene (pallor, pulseless, pain) is a surgical

emergency. Apixaban may have failed. Heparin is not definitive.

Do not elevate leg (reduces perfusion).

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ANCC AGACNP

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