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NEUROCOGNITIVE DISORDERS PRACTICE EXAM 2026 – 50+ QUESTIONS WITH CORRECT ANSWERS & DETAILED RATIONALES | DELIRIUM, DEMENTIA & ALZHEIMER'S PREP

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Master the assessment and management of neurocognitive disorders with this comprehensive practice exam. This resource delivers 50+ rigorous questions covering every essential topic: delirium (acute onset, fluctuating course, inattention – CAM assessment, hypoactive vs. hyperactive subtypes, risk factors – age 65, pre-existing dementia, sensory deficits; causes – infection, dehydration, medications – anticholinergics, benzodiazepines, opioids; management – identify and treat underlying cause, non-pharmacologic interventions – reorientation, sitters, sleep hygiene, early mobilization; pharmacotherapy – low-dose haloperidol for severe agitation, avoid benzodiazepines except alcohol withdrawal; prognosis – often reversible but may have long-term cognitive decline), Alzheimer's disease (early symptom – short-term memory loss, neuropathology – amyloid plaques and neurofibrillary tangles, cholinesterase inhibitors – donepezil, rivastigmine, galantamine; GI side effects nausea/diarrhea, bradycardia; memantine for moderate-to-severe Alzheimer's, cognitive stimulation therapy), frontotemporal dementia (behavioral variant – personality change, disinhibition, loss of empathy; primary progressive aphasia), Lewy body dementia (visual hallucinations, parkinsonism, fluctuating cognition, REM sleep behavior disorder), vascular dementia (stepwise decline, focal neurological signs, history of stroke or hypertension), Parkinson's disease dementia (cognitive decline in setting of established Parkinson's), Huntington's disease (genetic, chorea, cognitive decline, psychiatric symptoms), Creutzfeldt-Jakob disease (rapidly progressive dementia, myoclonus, EEG periodic sharp waves), dementia with Lewy bodies vs. Parkinson's disease dementia distinction (one-year rule), behavioral and psychological symptoms of dementia (BPSD) – non-pharmacologic first-line (identify triggers, calming approach, environment modification), brexpiprazole FDA-approved for agitation in Alzheimer's, antipsychotics black box warning for increased mortality and cerebrovascular events in elderly dementia patients, wandering safety measures (alarms, ID bracelet, safe area, no restraints), sundowning (worsening confusion in late afternoon/evening), caregiver support, and pharmacotherapy side effects (bradycardia from donepezil, torsades risk). Each question includes a verified correct answer and a detailed rationale teaching the why behind every answer—based on DSM-5-TR criteria, clinical practice guidelines, and evidence-based geriatric psychiatry. Perfect for medical students, psychiatry residents, nurse practitioners, physician assistants, geriatric nurses, and anyone preparing for neurocognitive disorders exams or clinical practice. No fluff—just high-yield, exam-focused content. Download instantly and master neurocognitive disorders today.

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Institution
NEUROCOGNITIVE DISORDERS
Course
NEUROCOGNITIVE DISORDERS

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Page 1 of 20


Neurocognitive Disorders Practice Questions & Verified
Answers | Psychiatric Nursing Review
1. A 78-year-old patient is admitted to the medical unit with
pneumonia. On day 2, the nurse notes the patient is confused,
disoriented, has fluctuating attention, and is picking at the
bedclothes. The nurse suspects:
a. Alzheimer’s disease
b. Delirium
c. Frontotemporal dementia
d. Major depressive disorder
Answer: b. Delirium
Rationale: Delirium is characterized by acute onset (hours to
days), fluctuating course, inattention, disorganized thinking, and
altered level of consciousness, often triggered by an acute
medical illness (pneumonia). Alzheimer’s has insidious onset.
2. The most important first step in managing a patient with
suspected delirium is:
a. Administer haloperidol immediately
b. Identify and treat the underlying cause
c. Restrain the patient to prevent falls
d. Obtain a brain MRI
Answer: b. Identify and treat the underlying cause
Rationale: Delirium is a medical emergency. The priority is to
find and correct the precipitating factor (e.g., infection,
electrolyte imbalance, medication). Antipsychotics are adjunctive,
not first-line.
3. Which of the following is a core feature of delirium according
to DSM-5-TR?

,Page 2 of 20


a. Insidious onset over months
b. Memory impairment without attention deficit
c. Disturbance in attention and awareness that develops over a
short period
d. Persistent personality change
Answer: c. Disturbance in attention and awareness that develops
over a short period
Rationale: The essential feature of delirium is an acute
disturbance in attention (reduced ability to focus, sustain, or shift
attention) and awareness (reduced orientation to environment),
with additional cognitive changes.
4. The Confusion Assessment Method (CAM) is a validated tool to
screen for:
a. Dementia
b. Delirium
c. Depression
d. Anxiety
Answer: b. Delirium
Rationale: The CAM assesses four features: acute onset and
fluctuating course, inattention, disorganized thinking, and altered
level of consciousness. It is the most widely used bedside delirium
assessment.
5. A patient with delirium is pulling at IV lines and attempting to
get out of bed. The nurse’s priority intervention is:
a. Apply wrist restraints
b. Administer lorazepam 2 mg IV
c. Provide a sitter, reorient frequently, and address underlying
cause
d. Turn off lights and leave the patient alone

, Page 3 of 20


Answer: c. Provide a sitter, reorient frequently, and address
underlying cause
Rationale: Non-pharmacologic interventions (reorientation,
frequent reassurance, presence of a sitter, reducing stimuli) are
first-line. Restraints are a last resort. Benzodiazepines can worsen
delirium except in alcohol withdrawal.
6. Which medication class is most likely to precipitate delirium in
older adults?
a. Anticholinergics
b. Beta-blockers
c. Statins
d. Proton pump inhibitors
Answer: a. Anticholinergics (e.g., diphenhydramine, oxybutynin,
tricyclics, atropine)
Rationale: Anticholinergic burden is a major risk factor for
delirium in the elderly, causing confusion, urinary retention, and
dry mouth. Other common precipitants include benzodiazepines,
opioids, and corticosteroids.
7. A patient with delirium has a fluctuating level of consciousness,
from hyperalert to lethargic. This pattern is best described as:
a. Sundowning
b. Diurnal variation
c. Fluctuating course
d. Circadian reversal
Answer: c. Fluctuating course
Rationale: A hallmark of delirium is that symptoms come and go
(fluctuate) over a 24-hour period, often worse at night
(sundowning), but the term “fluctuating course” is the DSM-5
descriptor.

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