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PEDIATRICS INFECTIOUS DISEASE FINAL EXAM 2026 – 200+ PRACTICE QUESTIONS & ANSWERS WITH RATIONALES

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Ace your Pediatrics Infectious Disease final exam with the most comprehensive practice test available. This PDF contains over 200 high-yield questions covering bacterial infections (meningitis, sepsis, pneumonia, osteomyelitis, UTI, impetigo, cellulitis, necrotizing fasciitis), viral infections (RSV bronchiolitis, croup, influenza, rotavirus, measles, rubella, roseola, fifth disease, EBV, CMV, HSV, varicella-zoster, enterovirus), fungal and parasitic infections (candidiasis, histoplasmosis, cryptococcal meningitis, aspergillosis, pinworm, giardiasis, toxoplasmosis, Lyme disease, cat-scratch disease, neurocysticercosis, leishmaniasis), immunocompromised and neonatal infections (GBS, late-onset sepsis, SCID, febrile neutropenia, congenital syphilis, neonatal HSV, PJP), immunization schedules (MMR, DTaP, rotavirus, hepatitis, HPV, Tdap, contraindications, post-exposure prophylaxis), and scenario-based clinical reasoning — each with clear answers and detailed rationales based on AAP Red Book and CDC 2026 guidelines. Perfect for medical students, pediatric residents, nurse practitioners, and PA students. Master the material, build clinical judgment, and pass your exam with confidence. Instant download.

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PEDIATRICS INFECTIOUS DISEASE
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PEDIATRICS INFECTIOUS DISEASE

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PEDIATRICS INFECTIOUS DISEASE

FINAL EXAM 2026|

150QS&AS|ALREADY GRADED A+

Q1. The most common cause of acute otitis media in children

under 2 years of age is:

A) Moraxella catarrhalis

B) Streptococcus pyogenes

C) Streptococcus pneumoniae

D) Haemophilus influenzae type b

Answer: C

Rationale: S. pneumoniae remains the leading pathogen, though H.

influenzae (non-typeable) and M. catarrhalis are also common.

Q2. A 4-year-old presents with fever, muffled voice, drooling,

and stridor. The most likely diagnosis is:

,Page 2 of 61


A) Croup

B) Bacterial tracheitis

C) Epiglottitis

D) Peritonsillar abscess

Answer: C

Rationale: Drooling, muffled voice, and stridor in an unvaccinated

or partially vaccinated child suggest epiglottitis (Hib or other

pathogens).

Q3. Which antibiotic is first-line for empiric treatment of

suspected neonatal sepsis (0–7 days) in a full-term infant?

A) Ampicillin + gentamicin

B) Vancomycin + cefotaxime

C) Cefotaxime alone

D) Ampicillin + cefotaxime

Answer: A

,Page 3 of 61


Rationale: Ampicillin covers Group B Strep and Listeria; gentamicin

covers Gram-negatives.

Q4. A child presents with a "bull's eye" rash after a tick bite.

The preferred outpatient therapy is:

A) Doxycycline for 28 days

B) Amoxicillin for 14 days (or doxycycline for 14 days if age

≥8)

C) Ceftriaxone IV

D) Azithromycin for 5 days

Answer: B

Rationale: Early localized Lyme disease: amoxicillin or doxycycline

for 14–21 days. Doxycycline avoided in <8 years unless necessary.

Q5. The classic "strawberry tongue" and desquamation of the

palms and soles are seen in:

A) Scarlet fever

B) Kawasaki disease

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C) Toxic shock syndrome

D) All of the above

Answer: D

Rationale: Strawberry tongue and desquamation occur in scarlet

fever (Group A Strep), Kawasaki disease, and staphylococcal TSS.

Q6. A 5-year-old with sickle cell disease presents with fever

and hip pain. The most likely pathogen is:

A) Streptococcus pneumoniae

B) Salmonella enterica

C) Staphylococcus aureus

D) E. coli

Answer: B

Rationale: Salmonella osteomyelitis is more common in sickle cell

patients, though S. aureus is still possible.

Q7. The most common cause of community-acquired

pneumonia in a fully immunized 3-year-old is:

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PEDIATRICS INFECTIOUS DISEASE
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PEDIATRICS INFECTIOUS DISEASE

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