TEST BANKt
Cellular and Molecular Immunology
t t t
Abul Abbas, Andrew Lichtman, and Shiv Pillai
t t t t t t
10th Edition
t
,Table of Contents
t t
Chapter 01 Properties and Overview of Immune Responses
t t t t t t t 1
Chapter 02 Cells and Tissues of the Immune System
t t t t t t t t 3
Chapter 03 Leukocyte Circulation and Migration Into Tissues
t t t t t t t 6
Chapter 04 Innate Immunity
t t t 10
Chapter 05 Antibodies and Antigens
t t t t 17
Chapter 06 Antigen Presentation to T Lymphocytes and the Functions of Major
t t t t t t t t t t t
Histocompatibility Complex Molecules t t 20
Chapter 07 Immune Receptors and Signal Transduction
t t t t t t 27
Chapter 08 Lymphocyte Development and Antigen Receptor Gene Rearrangement
t t t t t t t t 30
Chapter 09 Activation of T Lymphocytes
t t t t t 34
Chapter 10 Differentiation and Functions of CD4+ Effector T Cells
t t t t t t t t t 38
Chapter 11 Differentiation and Functions of CD8+ Effector T Cells
t t t t t t t t t 42
Chapter 12 B Cell Activation and Antibody Production
t t t t t t t 46
Chapter 13 Effector Mechanisms of Humoral Immunity
t t t t t t 52
Chapter 14 Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues
t t t t t t t t t t t 56
Chapter 15 Immunologic Tolerance and Autoimmunity
t t t t t 62
Chapter 16 Immunity to Microbes
t t t t 67
Chapter t 17 t Transplantation Immunology t 72
Chapter t 18 t Tumor Immunology t 77
Chapter t 19 t Hypersensitivity Disorders t 81
Chapter t 20 t Allergy 86
Chapter t 21 t Primary and Acquired Immunodeficiencies
t t t 89
,Chapter 01: Properties and Overview of Immune Responses
t t t t t t t
Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
t t t t t t t t t
MULTIPLE CHOICE t
1. The principal function of the immune system is:
t t t t t t t
a. Defense against cancer t t
b. Repair of injured tissues t t t
c. Defense against microbial infections t t t
d. Prevention of inflammatory diseases t t t
e. Protection against environmental toxins t t t
ANS: C
The immune system has evolved in the setting of selective pressures imposed by
t t t t t t t t t t t t
microbial infections. Although immune responses to cancer may occur, the concept that
t t t t t t t t t t t t
―immunosurveillance‖ against cancer is a principal function of the immune system is
t t t t t t t t t t t t
controversial. Repair of injured tissues may be a secondary consequence of the
t t t t t t t t t t t t
immune responses and inflammation. Although the immune system has regulatory features that
t t t t t t t t t t t t
are needed to prevent excessive inflammation, prevention of inflammatory diseases is
t t t t t t t t t t t
not a
t t
primary function. The immune system can protect against microbial toxins, but it generally does
t t t t t t t t t t t t t
not offer protection against toxins of nonbiologic origin.
t t t t t t t t
2. Which of the following infectious diseases was prevented by the first
t t t t t t t t t t
successful vaccination?
t t
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: C
In 1798, Edward Jenner reported the first intentional successful vaccination, which was
t t t t t t t t t t t
against smallpox in a boy, using material from the cowpox pustules of a milkmaid. In
t t t t t t t t t t t t t t t
1980, smallpox was reported to be eradicated worldwide by a vaccination program.
t t t t t t t t t t t t
Effective vaccines against tetanus toxin, rubella virus, and poliovirus were developed
t t t t t t t t t t
in the 20th century and are widely used. There is no effective vaccine against
t t t t t t t t t t t t t t
Mycobacterium tuberculosis.
t t
3. Which of the following is a unique property of the adaptive immune system?
t t t t t t t t t t t t
a. Highly diverse repertoire of specificities for antigens t t t t t t
b. Self-nonself discrimination t
c. Recognition of microbial structures by both cell-associated and soluble receptors t t t t t t t t t
d. Protection against viral infections t t t
e. Responses that have the same kinetics and magnitude on repeated exposure to the t t t t t t t t t t t t
same microbe t t
ANS: A
, Highly diverse repertoires of specificities for antigens are found only in T and B
t t t t t t t t t t t t t
lymphocytes, which are the central cellular components of the adaptive immune
t t t t t t t t t t t
system. Both the innate and the adaptive immune systems use cell-associated and
t t t t t t t t t t t t
soluble receptors to recognize microbes, display some degree of self-nonself discrimination,
t t t t t t t t t t t
and protect against viruses. On repeated exposure to the same microbe, the adaptive
t t t t t t t t t t t t t
immune response becomes more rapid and of greater magnitude; this is the
t t t t t t t t t t t t
manifestation of memory.
t t t
4. Antibodies and T lymphocytes are the respective mediators of which two types of t t t t t t t t t t t t
immunity?
t
a. Innate and adaptive t t
b. Passive and active t t
c. Specific and nonspecific t t
d. Humoral and cell-mediated t t
e. Adult and neonatal t t
ANS: D
Both B and T lymphocytes are principal components of adaptive immunity. B
t t t t t t t t t t t
lymphocytes produce antibodies, which are the recognition and effector molecules of
t t t t t t t t t t t
humoral immune responses to extracellular pathogens. T cells recognize and promote
t t t t t t t t t t t
eradication of intracellular pathogens in cell-mediated immunity. Passive and active
t t t t t t t t t t
immunity both can be mediated by either B or T lymphocytes. Specific immunity is
t t t t t t t t t t t t t t
another term for adaptive immunity. Both B and T lymphocytes participate in adult
t t t t t t t t t t t t t
adaptive immunity but are still developing in the neonatal period.
t t t t t t t t t t
5. The two major functional classes of effector T lymphocytes are:
t t t t t t t t t
a. Helper T lymphocytes and cytotoxic T lymphocytes t t t t t t
b. Natural killer cells and cytoWtoWxW
ic.TTlB
yS
mMph.oW
cyStes t t t t
c. Memory T cells and effector T cells t t t t t t
d. Helper cells and antigen-presenting cells t t t t
e. Cytotoxic T lymphocytes and target cells t t t t t
ANS: A
T cells can be classified into effector subsets that perform different effector functions. Most
t t t t t t t t t t t t t
effector T cells are either helper T lymphocytes, which enhance the responses of other
t t t t t t t t t t t t t t
immune cells, including phagocytes and B cells, to infections, or cytotoxic T
t t t t t t t t t t t t
lymphocytes, which directly kill infected cells. Natural killer cells are not T
t t t t t t t t t t t t
lymphocytes.
t
Antigen-presenting cells usually are not T cells. Memory T cells are not effector T cells. t t t t t t t t t t t t t t
6. Which of the following cell types is required for all adaptive humoral immune responses?
t t t t t t t t t t t t t
a. Natural killer cells t t
b. Dendritic cells t
c. Cytolytic T lymphocytes t t
d. B lymphocytes t
e. Helper T lymphocytes t t
ANS: D
Humoral immune responses are antibody-mediated immune responses, and all antibodies are
t t t t t t t t t t
made by B lymphocytes and no other cell type.
t t t t t t t t t
Cellular and Molecular Immunology
t t t
Abul Abbas, Andrew Lichtman, and Shiv Pillai
t t t t t t
10th Edition
t
,Table of Contents
t t
Chapter 01 Properties and Overview of Immune Responses
t t t t t t t 1
Chapter 02 Cells and Tissues of the Immune System
t t t t t t t t 3
Chapter 03 Leukocyte Circulation and Migration Into Tissues
t t t t t t t 6
Chapter 04 Innate Immunity
t t t 10
Chapter 05 Antibodies and Antigens
t t t t 17
Chapter 06 Antigen Presentation to T Lymphocytes and the Functions of Major
t t t t t t t t t t t
Histocompatibility Complex Molecules t t 20
Chapter 07 Immune Receptors and Signal Transduction
t t t t t t 27
Chapter 08 Lymphocyte Development and Antigen Receptor Gene Rearrangement
t t t t t t t t 30
Chapter 09 Activation of T Lymphocytes
t t t t t 34
Chapter 10 Differentiation and Functions of CD4+ Effector T Cells
t t t t t t t t t 38
Chapter 11 Differentiation and Functions of CD8+ Effector T Cells
t t t t t t t t t 42
Chapter 12 B Cell Activation and Antibody Production
t t t t t t t 46
Chapter 13 Effector Mechanisms of Humoral Immunity
t t t t t t 52
Chapter 14 Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues
t t t t t t t t t t t 56
Chapter 15 Immunologic Tolerance and Autoimmunity
t t t t t 62
Chapter 16 Immunity to Microbes
t t t t 67
Chapter t 17 t Transplantation Immunology t 72
Chapter t 18 t Tumor Immunology t 77
Chapter t 19 t Hypersensitivity Disorders t 81
Chapter t 20 t Allergy 86
Chapter t 21 t Primary and Acquired Immunodeficiencies
t t t 89
,Chapter 01: Properties and Overview of Immune Responses
t t t t t t t
Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
t t t t t t t t t
MULTIPLE CHOICE t
1. The principal function of the immune system is:
t t t t t t t
a. Defense against cancer t t
b. Repair of injured tissues t t t
c. Defense against microbial infections t t t
d. Prevention of inflammatory diseases t t t
e. Protection against environmental toxins t t t
ANS: C
The immune system has evolved in the setting of selective pressures imposed by
t t t t t t t t t t t t
microbial infections. Although immune responses to cancer may occur, the concept that
t t t t t t t t t t t t
―immunosurveillance‖ against cancer is a principal function of the immune system is
t t t t t t t t t t t t
controversial. Repair of injured tissues may be a secondary consequence of the
t t t t t t t t t t t t
immune responses and inflammation. Although the immune system has regulatory features that
t t t t t t t t t t t t
are needed to prevent excessive inflammation, prevention of inflammatory diseases is
t t t t t t t t t t t
not a
t t
primary function. The immune system can protect against microbial toxins, but it generally does
t t t t t t t t t t t t t
not offer protection against toxins of nonbiologic origin.
t t t t t t t t
2. Which of the following infectious diseases was prevented by the first
t t t t t t t t t t
successful vaccination?
t t
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: C
In 1798, Edward Jenner reported the first intentional successful vaccination, which was
t t t t t t t t t t t
against smallpox in a boy, using material from the cowpox pustules of a milkmaid. In
t t t t t t t t t t t t t t t
1980, smallpox was reported to be eradicated worldwide by a vaccination program.
t t t t t t t t t t t t
Effective vaccines against tetanus toxin, rubella virus, and poliovirus were developed
t t t t t t t t t t
in the 20th century and are widely used. There is no effective vaccine against
t t t t t t t t t t t t t t
Mycobacterium tuberculosis.
t t
3. Which of the following is a unique property of the adaptive immune system?
t t t t t t t t t t t t
a. Highly diverse repertoire of specificities for antigens t t t t t t
b. Self-nonself discrimination t
c. Recognition of microbial structures by both cell-associated and soluble receptors t t t t t t t t t
d. Protection against viral infections t t t
e. Responses that have the same kinetics and magnitude on repeated exposure to the t t t t t t t t t t t t
same microbe t t
ANS: A
, Highly diverse repertoires of specificities for antigens are found only in T and B
t t t t t t t t t t t t t
lymphocytes, which are the central cellular components of the adaptive immune
t t t t t t t t t t t
system. Both the innate and the adaptive immune systems use cell-associated and
t t t t t t t t t t t t
soluble receptors to recognize microbes, display some degree of self-nonself discrimination,
t t t t t t t t t t t
and protect against viruses. On repeated exposure to the same microbe, the adaptive
t t t t t t t t t t t t t
immune response becomes more rapid and of greater magnitude; this is the
t t t t t t t t t t t t
manifestation of memory.
t t t
4. Antibodies and T lymphocytes are the respective mediators of which two types of t t t t t t t t t t t t
immunity?
t
a. Innate and adaptive t t
b. Passive and active t t
c. Specific and nonspecific t t
d. Humoral and cell-mediated t t
e. Adult and neonatal t t
ANS: D
Both B and T lymphocytes are principal components of adaptive immunity. B
t t t t t t t t t t t
lymphocytes produce antibodies, which are the recognition and effector molecules of
t t t t t t t t t t t
humoral immune responses to extracellular pathogens. T cells recognize and promote
t t t t t t t t t t t
eradication of intracellular pathogens in cell-mediated immunity. Passive and active
t t t t t t t t t t
immunity both can be mediated by either B or T lymphocytes. Specific immunity is
t t t t t t t t t t t t t t
another term for adaptive immunity. Both B and T lymphocytes participate in adult
t t t t t t t t t t t t t
adaptive immunity but are still developing in the neonatal period.
t t t t t t t t t t
5. The two major functional classes of effector T lymphocytes are:
t t t t t t t t t
a. Helper T lymphocytes and cytotoxic T lymphocytes t t t t t t
b. Natural killer cells and cytoWtoWxW
ic.TTlB
yS
mMph.oW
cyStes t t t t
c. Memory T cells and effector T cells t t t t t t
d. Helper cells and antigen-presenting cells t t t t
e. Cytotoxic T lymphocytes and target cells t t t t t
ANS: A
T cells can be classified into effector subsets that perform different effector functions. Most
t t t t t t t t t t t t t
effector T cells are either helper T lymphocytes, which enhance the responses of other
t t t t t t t t t t t t t t
immune cells, including phagocytes and B cells, to infections, or cytotoxic T
t t t t t t t t t t t t
lymphocytes, which directly kill infected cells. Natural killer cells are not T
t t t t t t t t t t t t
lymphocytes.
t
Antigen-presenting cells usually are not T cells. Memory T cells are not effector T cells. t t t t t t t t t t t t t t
6. Which of the following cell types is required for all adaptive humoral immune responses?
t t t t t t t t t t t t t
a. Natural killer cells t t
b. Dendritic cells t
c. Cytolytic T lymphocytes t t
d. B lymphocytes t
e. Helper T lymphocytes t t
ANS: D
Humoral immune responses are antibody-mediated immune responses, and all antibodies are
t t t t t t t t t t
made by B lymphocytes and no other cell type.
t t t t t t t t t
