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CHEMOTHERAPY DRUGS QUESTIONS AND VERIFIED ANSWERS

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CHEMOTHERAPY DRUGS QUESTIONS AND VERIFIED ANSWERS

Institution
Chemotherapy
Course
Chemotherapy

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By injuring the epithelial lining of the GI tract,


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anticancer drugs often cause stomatitis and diarrhea.




Epidermal growth factor receptor linked with tyrosine kinase (EGFR-TK),


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a regulatory molecule found in certain normal cells and many cancer cells,
plays an important role in regulating cell proliferation.




Because alkylation reactions can take place at any time during the cell cycle,

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alkylating agents are considered cell-cycle phase- nonspecific.




Antiestrogens fall into two major categories:


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(1) pure estrogen receptor antagonists and (2) SERMs, which block
estrogen receptors in some tissues, and activate estrogen receptors in
others.




Early (localized) prostate cancer is treated with


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surgery or radiation, sometimes followed by androgen deprivation.




Cetuximab can cause


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severe infusion reactions and severe acne-like rash.




Anticancer drugs can cause fetal malformation and death:

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Accordingly, women undergoing chemotherapy should be warned against
becoming pregnant.




For drugs that act during a specific phase of the cell cycle:


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selecting the right dosing schedule is critical to success




Over the course of chemotherapy


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cancer cells often become drug resistant, thereby decreasing the chance
of success.




In addition to antiestrogens and aromatase inhibitors, breast cancer can be treated
with


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trastuzumab, a monoclonal antibody that binds with HER2, and thereby
inhibits cell proliferation and promotes immune-mediated cell death.

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Institution
Chemotherapy
Course
Chemotherapy

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